Single cell type - GLO1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GLO1
Gene descriptionⁱ Full gene name according to HGNC.	Glyoxalase I
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Enzymes Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Extravillous trophoblasts - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enriched (HMC-1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

GLO1 is part of cluster 38 Extravillous trophoblasts - Unknown function with confidenceⁱ 1
176 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PEX19	Peroxisomal biogenesis factor 19	0.5424	38
SH3GL1	SH3 domain containing GRB2 like 1, endophilin A2	0.5152	38
AC004556.3	39S ribosomal protein L23, mitochondrial	0.5121	38
MTSS2	MTSS I-BAR domain containing 2	0.5042	38
HROB	Homologous recombination factor with OB-fold	0.5011	38
MORF4L2	Mortality factor 4 like 2	0.5000	38
BCL2L12	BCL2 like 12	0.4946	12
HERC3	HECT and RLD domain containing E3 ubiquitin protein ligase 3	0.4932	38
MYDGF	Myeloid derived growth factor	0.4924	55
KRT33B	Keratin 33B	0.4874	38
TMED2	Transmembrane p24 trafficking protein 2	0.4811	55
COPZ1	COPI coat complex subunit zeta 1	0.4789	55
H2AZ2	H2A.Z variant histone 2	0.4769	24
ZDHHC16	Zinc finger DHHC-type palmitoyltransferase 16	0.4742	38
MANBAL	Mannosidase beta like	0.4722	22

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	69.2 nTPM
Adipose tissue	78.5 nTPM
Breast	59.8 nTPM

Alveolar cells type 1	131.4 nTPM
Lung	131.4 nTPM

Alveolar cells type 2	174.4 nTPM
Lung	174.4 nTPM

Astrocytes	26.1 nTPM
Brain	26.1 nTPM

B-cells	86.3 nTPM
Liver	139.6 nTPM
Spleen	100.4 nTPM
Adipose tissue	99.2 nTPM
PBMC	85.6 nTPM
Bone marrow	81.7 nTPM
Kidney	80.9 nTPM
Breast	78.8 nTPM
Stomach	77.2 nTPM
Lymph node	74.4 nTPM
Colon	44.8 nTPM

Dendritic cells	68.3 nTPM
PBMC	119.6 nTPM
Adipose tissue	44.0 nTPM
Breast	41.2 nTPM

Endothelial cells	74.3 nTPM
Placenta	130.7 nTPM
Prostate	111.1 nTPM
Testis	105.2 nTPM
Pancreas	88.8 nTPM
Eye	88.2 nTPM
Lung	68.6 nTPM
Skin	63.9 nTPM
Breast	63.7 nTPM
Liver	62.3 nTPM
Ovary	61.3 nTPM
Esophagus	54.6 nTPM
Heart muscle	51.7 nTPM
Skeletal muscle	45.8 nTPM
Endometrium	44.8 nTPM

Fibroblasts	86.0 nTPM
Placenta	161.2 nTPM
Ovary	113.3 nTPM
Adipose tissue	112.0 nTPM
Breast	79.1 nTPM
Stomach	74.3 nTPM
Prostate	72.8 nTPM
Skin	71.2 nTPM
Esophagus	67.6 nTPM
Lung	67.0 nTPM
Heart muscle	64.9 nTPM
Skeletal muscle	62.2 nTPM

Intestinal goblet cells	39.3 nTPM
Rectum	49.5 nTPM
Small intestine	39.0 nTPM
Colon	29.3 nTPM

Macrophages	70.0 nTPM
Esophagus	144.8 nTPM
Pancreas	132.7 nTPM
Prostate	119.3 nTPM
Lung	103.9 nTPM
Adipose tissue	93.9 nTPM
Ovary	73.6 nTPM
Testis	62.1 nTPM
Spleen	58.1 nTPM
Bone marrow	50.0 nTPM
Breast	48.1 nTPM
Endometrium	46.8 nTPM
Kidney	43.2 nTPM
Skeletal muscle	38.7 nTPM
Stomach	35.1 nTPM
PBMC	0.0 nTPM

Paneth cells	36.0 nTPM
Small intestine	48.8 nTPM
Rectum	39.4 nTPM
Colon	19.7 nTPM

Plasma cells	86.4 nTPM
Spleen	109.3 nTPM
Esophagus	86.2 nTPM
Adipose tissue	84.4 nTPM
Bone marrow	84.1 nTPM
Stomach	68.1 nTPM

Respiratory ciliated cells	80.7 nTPM
Lung	96.2 nTPM
Bronchus	65.1 nTPM

Smooth muscle cells	70.9 nTPM
Pancreas	146.9 nTPM
Prostate	85.7 nTPM
Ovary	83.1 nTPM
Adipose tissue	74.2 nTPM
Heart muscle	72.2 nTPM
Breast	68.3 nTPM
Skin	63.4 nTPM
Skeletal muscle	53.4 nTPM
Endometrium	49.2 nTPM
Esophagus	41.9 nTPM
Bronchus	41.8 nTPM

T-cells	62.4 nTPM
Skin	105.0 nTPM
Stomach	99.1 nTPM
Colon	82.7 nTPM
Lung	80.5 nTPM
Ovary	69.0 nTPM
Kidney	64.3 nTPM
Spleen	63.9 nTPM
Bone marrow	59.7 nTPM
Prostate	56.8 nTPM
Lymph node	54.4 nTPM
Liver	53.8 nTPM
Adipose tissue	53.6 nTPM
Breast	48.8 nTPM
Esophagus	45.9 nTPM
Endometrium	44.7 nTPM
PBMC	44.0 nTPM
Skeletal muscle	35.0 nTPM

Basal keratinocytes	64.6 nTPM
Skin	64.6 nTPM

Basal prostatic cells	112.6 nTPM
Prostate	112.6 nTPM

Basal squamous epithelial cells	37.0 nTPM
Esophagus	37.0 nTPM

Cholangiocytes	58.6 nTPM
Liver	58.6 nTPM

Undifferentiated cells	63.4 nTPM
Small intestine	69.9 nTPM
Colon	61.0 nTPM
Rectum	59.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC