Single cell type - ITPA - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ITPA
Gene descriptionⁱ Full gene name according to HGNC.	Inosine triphosphatase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ITPA is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 0.99
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
POLR2E	RNA polymerase II, I and III subunit E	0.5920	3
GADD45GIP1	GADD45G interacting protein 1	0.5912	39
PPP2R1A	Protein phosphatase 2 scaffold subunit Aalpha	0.5576	53
MRPS12	Mitochondrial ribosomal protein S12	0.5536	39
FAM207A	Family with sequence similarity 207 member A	0.5522	39
STOML2	Stomatin like 2	0.5519	39
CDK4	Cyclin dependent kinase 4	0.5442	39
TOMM40	Translocase of outer mitochondrial membrane 40	0.5415	39
URM1	Ubiquitin related modifier 1	0.5413	39
MRPL3	Mitochondrial ribosomal protein L3	0.5383	39
B4GALT7	Beta-1,4-galactosyltransferase 7	0.5332	38
NEK6	NIMA related kinase 6	0.5292	38
MMP12	Matrix metallopeptidase 12	0.5230	38
YDJC	YdjC chitooligosaccharide deacetylase homolog	0.5230	1
ENO1	Enolase 1	0.5201	16

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	29.4 nTPM
Breast	33.6 nTPM
Adipose tissue	25.1 nTPM

Alveolar cells type 1	22.4 nTPM
Lung	22.4 nTPM

Alveolar cells type 2	47.0 nTPM
Lung	47.0 nTPM

Astrocytes	15.3 nTPM
Brain	15.3 nTPM

B-cells	38.0 nTPM
Liver	64.1 nTPM
Spleen	44.0 nTPM
Lymph node	43.9 nTPM
Breast	37.5 nTPM
Colon	36.7 nTPM
Adipose tissue	35.1 nTPM
Kidney	33.4 nTPM
Stomach	30.9 nTPM
Bone marrow	30.2 nTPM
PBMC	24.3 nTPM

Dendritic cells	45.9 nTPM
Breast	63.1 nTPM
Adipose tissue	50.7 nTPM
PBMC	23.9 nTPM

Endothelial cells	29.4 nTPM
Pancreas	61.8 nTPM
Placenta	60.8 nTPM
Ovary	45.2 nTPM
Endometrium	35.6 nTPM
Breast	32.1 nTPM
Skin	28.7 nTPM
Eye	28.3 nTPM
Prostate	21.6 nTPM
Liver	20.2 nTPM
Esophagus	20.0 nTPM
Testis	17.7 nTPM
Skeletal muscle	16.6 nTPM
Lung	15.6 nTPM
Heart muscle	7.6 nTPM

Fibroblasts	41.8 nTPM
Placenta	66.4 nTPM
Ovary	59.2 nTPM
Adipose tissue	55.2 nTPM
Breast	44.7 nTPM
Skin	44.3 nTPM
Lung	35.7 nTPM
Skeletal muscle	35.4 nTPM
Heart muscle	34.0 nTPM
Esophagus	30.9 nTPM
Prostate	30.2 nTPM
Stomach	23.7 nTPM

Intestinal goblet cells	53.1 nTPM
Colon	60.8 nTPM
Small intestine	49.2 nTPM
Rectum	49.2 nTPM

Macrophages	49.0 nTPM
Pancreas	97.0 nTPM
Ovary	76.0 nTPM
Lung	64.1 nTPM
Kidney	61.3 nTPM
Adipose tissue	54.4 nTPM
Breast	49.1 nTPM
Prostate	47.0 nTPM
Endometrium	46.5 nTPM
Bone marrow	40.0 nTPM
Testis	39.5 nTPM
Stomach	38.1 nTPM
Skeletal muscle	37.0 nTPM
Esophagus	36.2 nTPM
Spleen	35.3 nTPM
PBMC	13.6 nTPM

Paneth cells	59.9 nTPM
Rectum	80.7 nTPM
Small intestine	56.3 nTPM
Colon	42.8 nTPM

Plasma cells	34.5 nTPM
Bone marrow	49.4 nTPM
Spleen	40.3 nTPM
Stomach	35.6 nTPM
Esophagus	24.6 nTPM
Adipose tissue	22.5 nTPM

Respiratory ciliated cells	37.9 nTPM
Bronchus	46.7 nTPM
Lung	29.1 nTPM

Smooth muscle cells	45.0 nTPM
Pancreas	109.3 nTPM
Ovary	67.9 nTPM
Endometrium	48.5 nTPM
Prostate	40.9 nTPM
Adipose tissue	40.0 nTPM
Skin	37.6 nTPM
Skeletal muscle	36.3 nTPM
Breast	35.1 nTPM
Esophagus	29.4 nTPM
Bronchus	28.9 nTPM
Heart muscle	21.3 nTPM

T-cells	47.2 nTPM
Ovary	84.5 nTPM
Kidney	67.8 nTPM
Liver	60.1 nTPM
Colon	51.3 nTPM
Skin	51.1 nTPM
Lung	48.6 nTPM
Adipose tissue	46.4 nTPM
Stomach	44.8 nTPM
Skeletal muscle	43.3 nTPM
PBMC	43.0 nTPM
Spleen	40.7 nTPM
Bone marrow	39.8 nTPM
Breast	39.7 nTPM
Lymph node	38.0 nTPM
Endometrium	36.9 nTPM
Prostate	33.1 nTPM
Esophagus	32.8 nTPM

Basal keratinocytes	40.1 nTPM
Skin	40.1 nTPM

Basal prostatic cells	50.5 nTPM
Prostate	50.5 nTPM

Basal respiratory cells	93.2 nTPM
Bronchus	93.2 nTPM

Basal squamous epithelial cells	56.9 nTPM
Esophagus	56.9 nTPM

Undifferentiated cells	79.9 nTPM
Colon	93.7 nTPM
Small intestine	78.9 nTPM
Rectum	67.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC