Single cell type - QRSL1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	QRSL1
Gene descriptionⁱ Full gene name according to HGNC.	Glutaminyl-tRNA amidotransferase subunit QRSL1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	B-cells - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (B-cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (memory B-cell, naive B-cell)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (B-cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

QRSL1 is part of cluster 57 B-cells - Immune response with confidenceⁱ 1
204 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CD79B	CD79b molecule	0.7534	57
CNR2	Cannabinoid receptor 2	0.7494	57
TNFRSF13C	TNF receptor superfamily member 13C	0.7260	57
FCRLA	Fc receptor like A	0.7152	57
CD22	CD22 molecule	0.7080	57
HLA-DOB	Major histocompatibility complex, class II, DO beta	0.7077	57
BLK	BLK proto-oncogene, Src family tyrosine kinase	0.7048	57
ZNF860	Zinc finger protein 860	0.6962	57
BTLA	B and T lymphocyte associated	0.6958	57
TLR10	Toll like receptor 10	0.6927	57
P2RX5	Purinergic receptor P2X 5	0.6897	57
CD37	CD37 molecule	0.6893	57
MS4A1	Membrane spanning 4-domains A1	0.6829	57
FCER2	Fc fragment of IgE receptor II	0.6808	57
FCRL2	Fc receptor like 2	0.6757	57

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	9.0 nTPM
Breast	10.4 nTPM
Adipose tissue	7.6 nTPM

Alveolar cells type 1	19.2 nTPM
Lung	19.2 nTPM

Alveolar cells type 2	12.5 nTPM
Lung	12.5 nTPM

Astrocytes	20.2 nTPM
Brain	20.2 nTPM

Basal keratinocytes	4.0 nTPM
Skin	4.0 nTPM

B-cells	64.6 nTPM
PBMC	169.9 nTPM
Kidney	123.8 nTPM
Bone marrow	80.9 nTPM
Stomach	54.0 nTPM
Lymph node	50.2 nTPM
Spleen	46.1 nTPM
Liver	34.6 nTPM
Breast	33.4 nTPM
Colon	28.7 nTPM
Adipose tissue	24.6 nTPM

Dendritic cells	12.3 nTPM
PBMC	16.0 nTPM
Adipose tissue	10.7 nTPM
Breast	10.2 nTPM

Endothelial cells	10.8 nTPM
Lung	15.6 nTPM
Pancreas	15.5 nTPM
Testis	15.4 nTPM
Esophagus	14.3 nTPM
Eye	12.2 nTPM
Skeletal muscle	11.5 nTPM
Ovary	10.6 nTPM
Heart muscle	10.4 nTPM
Placenta	9.7 nTPM
Breast	8.7 nTPM
Endometrium	8.6 nTPM
Liver	8.2 nTPM
Skin	5.3 nTPM
Prostate	4.5 nTPM

Fibroblasts	9.9 nTPM
Heart muscle	15.2 nTPM
Ovary	13.7 nTPM
Lung	13.4 nTPM
Stomach	10.4 nTPM
Skeletal muscle	9.6 nTPM
Adipose tissue	9.6 nTPM
Esophagus	9.0 nTPM
Breast	8.6 nTPM
Placenta	8.5 nTPM
Prostate	7.0 nTPM
Skin	4.3 nTPM

Intestinal goblet cells	11.2 nTPM
Rectum	14.4 nTPM
Small intestine	9.9 nTPM
Colon	9.3 nTPM

Macrophages	10.0 nTPM
Kidney	16.6 nTPM
Lung	16.5 nTPM
Breast	12.1 nTPM
Spleen	11.4 nTPM
Bone marrow	11.3 nTPM
Esophagus	11.0 nTPM
Endometrium	10.9 nTPM
Skeletal muscle	10.9 nTPM
Ovary	10.8 nTPM
Testis	9.8 nTPM
Prostate	8.1 nTPM
Pancreas	7.7 nTPM
Adipose tissue	7.4 nTPM
Stomach	5.9 nTPM
PBMC	0.0 nTPM

Paneth cells	8.3 nTPM
Rectum	10.7 nTPM
Small intestine	7.5 nTPM
Colon	6.5 nTPM

Plasma cells	13.2 nTPM
Spleen	21.8 nTPM
Bone marrow	14.8 nTPM
Stomach	12.5 nTPM
Esophagus	12.3 nTPM
Adipose tissue	4.5 nTPM

Respiratory ciliated cells	19.9 nTPM
Lung	29.1 nTPM
Bronchus	10.6 nTPM

Smooth muscle cells	10.0 nTPM
Heart muscle	19.6 nTPM
Pancreas	16.0 nTPM
Ovary	11.6 nTPM
Endometrium	9.8 nTPM
Skeletal muscle	9.8 nTPM
Adipose tissue	7.9 nTPM
Breast	7.9 nTPM
Bronchus	7.7 nTPM
Skin	7.0 nTPM
Prostate	6.2 nTPM
Esophagus	6.2 nTPM

Cholangiocytes	7.2 nTPM
Liver	7.2 nTPM

Cone photoreceptor cells	16.7 nTPM
Eye	16.7 nTPM

Cytotrophoblasts	21.5 nTPM
Placenta	21.5 nTPM

Distal tubular cells	17.6 nTPM
Kidney	17.6 nTPM

T-cells	14.3 nTPM
Lung	33.4 nTPM
Esophagus	26.2 nTPM
PBMC	21.2 nTPM
Lymph node	18.2 nTPM
Bone marrow	15.9 nTPM
Prostate	14.2 nTPM
Stomach	13.7 nTPM
Liver	13.4 nTPM
Spleen	13.3 nTPM
Colon	12.4 nTPM
Ovary	11.1 nTPM
Endometrium	10.6 nTPM
Kidney	9.6 nTPM
Breast	8.6 nTPM
Skeletal muscle	8.2 nTPM
Adipose tissue	7.3 nTPM
Skin	6.4 nTPM

Undifferentiated cells	18.7 nTPM
Rectum	22.4 nTPM
Small intestine	20.4 nTPM
Colon	13.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC