Single cell type - ZNF236 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZNF236
Gene descriptionⁱ Full gene name according to HGNC.	Zinc finger protein 236
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ZNF236 is part of cluster 52 Non-specific - Transcription with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
S100PBP	S100P binding protein	0.5050	13
ZNF557	Zinc finger protein 557	0.4936	52
ZNF98	Zinc finger protein 98	0.4881	20
SFSWAP	Splicing factor SWAP	0.4856	52
ZNF280C	Zinc finger protein 280C	0.4825	13
CNTLN	Centlein	0.4765	52
KDM5A	Lysine demethylase 5A	0.4668	65
AKAP10	A-kinase anchoring protein 10	0.4644	52
RPAP1	RNA polymerase II associated protein 1	0.4589	52
ZNF518A	Zinc finger protein 518A	0.4572	52
DBF4B	DBF4 zinc finger B	0.4569	13
MTBP	MDM2 binding protein	0.4542	12
ZNF714	Zinc finger protein 714	0.4478	52
ZFP69B	ZFP69 zinc finger protein B	0.4452	21
GIGYF1	GRB10 interacting GYF protein 1	0.4429	52

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	9.3 nTPM
Adipose tissue	11.3 nTPM
Breast	7.2 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	7.9 nTPM
Lung	7.9 nTPM

Astrocytes	39.5 nTPM
Brain	39.5 nTPM

B-cells	11.9 nTPM
Adipose tissue	20.6 nTPM
Stomach	18.6 nTPM
Bone marrow	14.7 nTPM
PBMC	14.3 nTPM
Colon	12.8 nTPM
Spleen	10.0 nTPM
Lymph node	9.5 nTPM
Breast	9.4 nTPM
Kidney	4.8 nTPM
Liver	4.2 nTPM

Dendritic cells	12.9 nTPM
Adipose tissue	16.5 nTPM
PBMC	12.0 nTPM
Breast	10.2 nTPM

Endothelial cells	9.3 nTPM
Eye	12.9 nTPM
Lung	12.5 nTPM
Placenta	12.5 nTPM
Skeletal muscle	11.6 nTPM
Prostate	10.9 nTPM
Esophagus	9.8 nTPM
Ovary	9.7 nTPM
Endometrium	9.2 nTPM
Testis	8.3 nTPM
Skin	8.1 nTPM
Heart muscle	7.7 nTPM
Breast	7.2 nTPM
Liver	6.4 nTPM
Pancreas	3.9 nTPM

Fibroblasts	8.8 nTPM
Skeletal muscle	13.5 nTPM
Ovary	12.1 nTPM
Adipose tissue	10.9 nTPM
Skin	10.0 nTPM
Esophagus	9.2 nTPM
Prostate	8.9 nTPM
Breast	8.0 nTPM
Stomach	7.4 nTPM
Placenta	6.5 nTPM
Heart muscle	5.4 nTPM
Lung	4.5 nTPM

Intestinal goblet cells	5.0 nTPM
Colon	5.8 nTPM
Rectum	5.4 nTPM
Small intestine	3.8 nTPM

Macrophages	8.7 nTPM
Bone marrow	15.0 nTPM
Ovary	13.2 nTPM
Adipose tissue	13.1 nTPM
Spleen	12.5 nTPM
Skeletal muscle	12.2 nTPM
Esophagus	11.0 nTPM
Endometrium	9.6 nTPM
Breast	9.2 nTPM
Stomach	8.8 nTPM
Lung	7.0 nTPM
Testis	6.9 nTPM
Kidney	6.8 nTPM
Prostate	4.6 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM

Paneth cells	3.1 nTPM
Rectum	6.1 nTPM
Colon	3.3 nTPM
Small intestine	0.0 nTPM

Plasma cells	9.1 nTPM
Adipose tissue	13.0 nTPM
Esophagus	12.3 nTPM
Spleen	8.5 nTPM
Stomach	8.3 nTPM
Bone marrow	3.3 nTPM

Respiratory ciliated cells	10.9 nTPM
Lung	16.0 nTPM
Bronchus	5.7 nTPM

Smooth muscle cells	10.4 nTPM
Heart muscle	17.5 nTPM
Esophagus	17.0 nTPM
Skeletal muscle	14.7 nTPM
Endometrium	12.8 nTPM
Adipose tissue	12.5 nTPM
Ovary	10.4 nTPM
Prostate	9.4 nTPM
Breast	6.9 nTPM
Skin	6.3 nTPM
Pancreas	3.9 nTPM
Bronchus	2.9 nTPM

T-cells	12.4 nTPM
Esophagus	26.2 nTPM
Skeletal muscle	16.9 nTPM
Adipose tissue	16.2 nTPM
Bone marrow	15.3 nTPM
Colon	14.7 nTPM
Breast	14.5 nTPM
PBMC	14.3 nTPM
Spleen	14.2 nTPM
Endometrium	13.1 nTPM
Stomach	12.6 nTPM
Lymph node	11.8 nTPM
Liver	9.9 nTPM
Lung	9.1 nTPM
Ovary	8.9 nTPM
Kidney	6.9 nTPM
Skin	5.5 nTPM
Prostate	0.0 nTPM

Basal keratinocytes	7.1 nTPM
Skin	7.1 nTPM

Basal squamous epithelial cells	10.8 nTPM
Esophagus	10.8 nTPM

Collecting duct cells	7.3 nTPM
Kidney	7.3 nTPM

Cytotrophoblasts	8.4 nTPM
Placenta	8.4 nTPM

Undifferentiated cells	5.7 nTPM
Small intestine	6.0 nTPM
Rectum	5.7 nTPM
Colon	5.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC