Single cell type - ABCB7 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ABCB7
Gene descriptionⁱ Full gene name according to HGNC.	ATP binding cassette subfamily B member 7
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Plasma proteins Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ABCB7 is part of cluster 59 Non-specific - Transcription with confidenceⁱ 0.97
354 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
INTS9	Integrator complex subunit 9	0.5685	59
NSMAF	Neutral sphingomyelinase activation associated factor	0.5463	4
FCHSD2	FCH and double SH3 domains 2	0.5323	68
LRPPRC	Leucine rich pentatricopeptide repeat containing	0.5222	39
RIC1	RIC1 homolog, RAB6A GEF complex partner 1	0.5157	57
SLC25A40	Solute carrier family 25 member 40	0.5135	19
PIKFYVE	Phosphoinositide kinase, FYVE-type zinc finger containing	0.5098	57
MANBA	Mannosidase beta	0.5012	57
FAM13B	Family with sequence similarity 13 member B	0.4993	59
PDSS2	Decaprenyl diphosphate synthase subunit 2	0.4868	42
TMLHE	Trimethyllysine hydroxylase, epsilon	0.4832	68
RB1	RB transcriptional corepressor 1	0.4791	41
METTL8	Methyltransferase like 8	0.4781	57
ZCCHC7	Zinc finger CCHC-type containing 7	0.4748	57
ZNF564	Zinc finger protein 564	0.4686	59

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	12.0 nTPM
Adipose tissue	12.8 nTPM
Breast	11.2 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	10.4 nTPM
Lung	10.4 nTPM

Astrocytes	48.0 nTPM
Brain	48.0 nTPM

B-cells	26.6 nTPM
Stomach	45.0 nTPM
Bone marrow	36.8 nTPM
Lymph node	36.5 nTPM
Spleen	34.3 nTPM
Kidney	33.4 nTPM
Adipose tissue	20.1 nTPM
PBMC	20.0 nTPM
Colon	17.6 nTPM
Liver	13.1 nTPM
Breast	9.4 nTPM

Dendritic cells	19.0 nTPM
PBMC	27.9 nTPM
Adipose tissue	16.3 nTPM
Breast	12.8 nTPM

Endothelial cells	11.9 nTPM
Heart muscle	17.8 nTPM
Eye	16.2 nTPM
Placenta	13.1 nTPM
Ovary	13.1 nTPM
Prostate	12.9 nTPM
Liver	12.8 nTPM
Testis	12.5 nTPM
Skeletal muscle	12.4 nTPM
Esophagus	11.8 nTPM
Endometrium	11.6 nTPM
Breast	9.7 nTPM
Skin	8.4 nTPM
Pancreas	7.7 nTPM
Lung	6.2 nTPM

Fibroblasts	13.9 nTPM
Esophagus	19.5 nTPM
Adipose tissue	17.7 nTPM
Lung	16.8 nTPM
Heart muscle	16.1 nTPM
Skeletal muscle	15.6 nTPM
Ovary	13.8 nTPM
Placenta	11.6 nTPM
Skin	11.4 nTPM
Breast	11.2 nTPM
Prostate	10.1 nTPM
Stomach	8.9 nTPM

Intestinal goblet cells	10.5 nTPM
Rectum	15.7 nTPM
Small intestine	10.7 nTPM
Colon	5.0 nTPM

Macrophages	19.2 nTPM
Stomach	32.2 nTPM
Ovary	27.6 nTPM
Adipose tissue	27.3 nTPM
Pancreas	25.5 nTPM
Testis	25.0 nTPM
Bone marrow	25.0 nTPM
Spleen	23.9 nTPM
Kidney	21.9 nTPM
Skeletal muscle	17.7 nTPM
Breast	14.7 nTPM
Lung	13.8 nTPM
Prostate	13.8 nTPM
Endometrium	10.6 nTPM
Esophagus	9.4 nTPM
PBMC	0.0 nTPM

Paneth cells	7.9 nTPM
Rectum	17.2 nTPM
Colon	6.5 nTPM
Small intestine	0.0 nTPM

Plasma cells	14.3 nTPM
Stomach	23.8 nTPM
Spleen	22.7 nTPM
Bone marrow	16.5 nTPM
Adipose tissue	8.4 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	10.7 nTPM
Lung	11.7 nTPM
Bronchus	9.6 nTPM

Smooth muscle cells	13.8 nTPM
Prostate	17.5 nTPM
Skin	16.4 nTPM
Ovary	16.2 nTPM
Adipose tissue	15.6 nTPM
Esophagus	15.5 nTPM
Skeletal muscle	14.0 nTPM
Heart muscle	13.7 nTPM
Breast	12.8 nTPM
Endometrium	12.2 nTPM
Pancreas	9.2 nTPM
Bronchus	8.4 nTPM

T-cells	14.5 nTPM
Bone marrow	25.3 nTPM
Stomach	24.2 nTPM
Spleen	23.7 nTPM
Lymph node	23.3 nTPM
PBMC	18.5 nTPM
Adipose tissue	16.5 nTPM
Colon	15.7 nTPM
Liver	14.7 nTPM
Prostate	14.2 nTPM
Breast	12.5 nTPM
Skin	11.9 nTPM
Endometrium	11.3 nTPM
Skeletal muscle	11.2 nTPM
Kidney	10.9 nTPM
Ovary	6.7 nTPM
Lung	6.1 nTPM
Esophagus	0.0 nTPM

Basal keratinocytes	15.8 nTPM
Skin	15.8 nTPM

Basal respiratory cells	16.0 nTPM
Bronchus	16.0 nTPM

Basal squamous epithelial cells	19.9 nTPM
Esophagus	19.9 nTPM

Collecting duct cells	11.0 nTPM
Kidney	11.0 nTPM

Undifferentiated cells	17.9 nTPM
Small intestine	22.0 nTPM
Rectum	18.0 nTPM
Colon	13.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC