Cell line - TRIM22 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TRIM22
Gene descriptionⁱ Full gene name according to HGNC.	Tripartite motif containing 22
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	TIME & HUVEC/TERT2 - Endothelial cell function (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (ASC TERT1, BJ hTERT+ SV40 Large T+ RasG12V, HSkMC, TIME)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

TRIM22 is part of cluster 41 TIME & HUVEC/TERT2 - Endothelial cell function with confidenceⁱ 1
476 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
VAMP5	Vesicle associated membrane protein 5	0.7372	41
RRAS	RAS related	0.6988	34
MAPK3	Mitogen-activated protein kinase 3	0.6868	41
ACE	Angiotensin I converting enzyme	0.6472	41
OSTC	Oligosaccharyltransferase complex non-catalytic subunit	0.6362	41
TMEM26	Transmembrane protein 26	0.6326	10
PKIG	CAMP-dependent protein kinase inhibitor gamma	0.6304	10
MGARP	Mitochondria localized glutamic acid rich protein	0.6291	41
TNFSF4	TNF superfamily member 4	0.6243	41
PCDHGA2	Protocadherin gamma subfamily A, 2	0.6194	34
ZFPM2	Zinc finger protein, FOG family member 2	0.6166	41
NRP1	Neuropilin 1	0.6123	10
ADAMTSL1	ADAMTS like 1	0.6111	41
SPOCK1	SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1	0.6107	11
PFDN5	Prefoldin subunit 5	0.6069	34