Single cell type - TMEM128 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TMEM128
Gene descriptionⁱ Full gene name according to HGNC.	Transmembrane protein 128
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Respiratory epithelial cells - Mucosal defense (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TMEM128 is part of cluster 26 Respiratory epithelial cells - Mucosal defense with confidenceⁱ 1
293 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TM2D1	TM2 domain containing 1	0.8118	26
UNC50	Unc-50 inner nuclear membrane RNA binding protein	0.5830	26
ARL1	ADP ribosylation factor like GTPase 1	0.5730	26
SFT2D1	SFT2 domain containing 1	0.5703	26
TCEAL8	Transcription elongation factor A like 8	0.5529	39
SNAPC1	Small nuclear RNA activating complex polypeptide 1	0.5528	26
TEX264	Testis expressed 264, ER-phagy receptor	0.5526	13
EMC2	ER membrane protein complex subunit 2	0.5477	26
CRELD1	Cysteine rich with EGF like domains 1	0.5379	13
JAGN1	Jagunal homolog 1	0.5362	39
TMEM59	Transmembrane protein 59	0.5358	26
PENK	Proenkephalin	0.5283	26
TAF12	TATA-box binding protein associated factor 12	0.5272	13
ZFYVE21	Zinc finger FYVE-type containing 21	0.5225	26
PPIC	Peptidylprolyl isomerase C	0.5182	33

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	20.7 nTPM
Breast	21.6 nTPM
Adipose tissue	19.7 nTPM

Alveolar cells type 1	12.8 nTPM
Lung	12.8 nTPM

Alveolar cells type 2	22.7 nTPM
Lung	22.7 nTPM

Astrocytes	8.8 nTPM
Brain	8.8 nTPM

B-cells	13.8 nTPM
PBMC	28.5 nTPM
Liver	16.4 nTPM
Colon	16.0 nTPM
Kidney	14.3 nTPM
Spleen	12.5 nTPM
Breast	12.1 nTPM
Stomach	11.8 nTPM
Bone marrow	11.5 nTPM
Lymph node	10.6 nTPM
Adipose tissue	4.5 nTPM

Dendritic cells	17.3 nTPM
PBMC	20.0 nTPM
Breast	20.0 nTPM
Adipose tissue	11.9 nTPM

Endothelial cells	18.6 nTPM
Liver	28.4 nTPM
Heart muscle	28.3 nTPM
Testis	26.4 nTPM
Breast	24.6 nTPM
Placenta	23.3 nTPM
Pancreas	23.1 nTPM
Skin	22.0 nTPM
Skeletal muscle	17.5 nTPM
Eye	16.2 nTPM
Endometrium	13.2 nTPM
Prostate	11.9 nTPM
Esophagus	9.7 nTPM
Ovary	8.9 nTPM
Lung	6.2 nTPM

Fibroblasts	23.1 nTPM
Placenta	47.9 nTPM
Adipose tissue	36.5 nTPM
Breast	34.2 nTPM
Skin	33.2 nTPM
Skeletal muscle	25.6 nTPM
Esophagus	20.3 nTPM
Prostate	15.8 nTPM
Ovary	15.1 nTPM
Lung	11.1 nTPM
Heart muscle	8.2 nTPM
Stomach	6.0 nTPM

Intestinal goblet cells	23.2 nTPM
Rectum	26.1 nTPM
Small intestine	25.7 nTPM
Colon	17.9 nTPM

Macrophages	14.9 nTPM
Lung	33.0 nTPM
Testis	23.2 nTPM
Kidney	21.9 nTPM
Breast	19.5 nTPM
Bone marrow	15.0 nTPM
PBMC	13.6 nTPM
Pancreas	12.8 nTPM
Spleen	12.5 nTPM
Skeletal muscle	12.0 nTPM
Endometrium	11.9 nTPM
Prostate	11.5 nTPM
Ovary	11.3 nTPM
Adipose tissue	11.2 nTPM
Esophagus	7.9 nTPM
Stomach	5.9 nTPM

Paneth cells	33.9 nTPM
Small intestine	45.0 nTPM
Rectum	33.6 nTPM
Colon	23.1 nTPM

Plasma cells	5.7 nTPM
Stomach	9.7 nTPM
Spleen	9.4 nTPM
Bone marrow	8.2 nTPM
Adipose tissue	1.3 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	32.6 nTPM
Bronchus	38.9 nTPM
Lung	26.2 nTPM

Smooth muscle cells	20.3 nTPM
Pancreas	36.3 nTPM
Skeletal muscle	28.1 nTPM
Adipose tissue	25.6 nTPM
Breast	22.0 nTPM
Ovary	21.9 nTPM
Skin	16.4 nTPM
Heart muscle	15.8 nTPM
Endometrium	15.2 nTPM
Prostate	14.4 nTPM
Bronchus	14.1 nTPM
Esophagus	14.0 nTPM

T-cells	16.3 nTPM
PBMC	33.4 nTPM
Kidney	30.2 nTPM
Liver	28.9 nTPM
Skin	20.7 nTPM
Esophagus	19.7 nTPM
Breast	17.9 nTPM
Bone marrow	16.3 nTPM
Ovary	15.6 nTPM
Lymph node	15.0 nTPM
Lung	12.2 nTPM
Spleen	12.1 nTPM
Stomach	12.0 nTPM
Colon	11.4 nTPM
Adipose tissue	10.7 nTPM
Endometrium	10.6 nTPM
Skeletal muscle	10.0 nTPM
Prostate	0.0 nTPM

Basal keratinocytes	17.8 nTPM
Skin	17.8 nTPM

Basal respiratory cells	63.5 nTPM
Bronchus	63.5 nTPM

Cholangiocytes	24.3 nTPM
Liver	24.3 nTPM

Collecting duct cells	31.3 nTPM
Kidney	31.3 nTPM

Undifferentiated cells	17.7 nTPM
Small intestine	21.6 nTPM
Rectum	18.2 nTPM
Colon	13.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC