Single cell type - GPS2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GPS2
Gene descriptionⁱ Full gene name according to HGNC.	G protein pathway suppressor 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

GPS2 is part of cluster 31 Spermatids - Spermatogenesis with confidenceⁱ 1
413 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
RAB2B	RAB2B, member RAS oncogene family	0.5182	24
SURF2	Surfeit 2	0.5131	31
HERPUD2	HERPUD family member 2	0.5041	31
DALRD3	DALR anticodon binding domain containing 3	0.4901	31
EIF5A2	Eukaryotic translation initiation factor 5A2	0.4894	34
TMEM131L	Transmembrane 131 like	0.4771	7
EIF2B4	Eukaryotic translation initiation factor 2B subunit delta	0.4725	31
TLE4	TLE family member 4, transcriptional corepressor	0.4686	34
ARL2	ADP ribosylation factor like GTPase 2	0.4684	31
PRKAA1	Protein kinase AMP-activated catalytic subunit alpha 1	0.4678	31
IFT57	Intraflagellar transport 57	0.4642	34
MECP2	Methyl-CpG binding protein 2	0.4641	24
PRPF4B	Pre-mRNA processing factor 4B	0.4617	52
SPATA33	Spermatogenesis associated 33	0.4576	34
MIB2	Mindbomb E3 ubiquitin protein ligase 2	0.4544	63

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	29.1 nTPM
Breast	32.0 nTPM
Adipose tissue	26.3 nTPM

Alveolar cells type 1	12.8 nTPM
Lung	12.8 nTPM

Alveolar cells type 2	10.8 nTPM
Lung	10.8 nTPM

Astrocytes	19.9 nTPM
Brain	19.9 nTPM

B-cells	36.9 nTPM
Adipose tissue	64.1 nTPM
Colon	46.4 nTPM
Stomach	45.0 nTPM
Lymph node	41.8 nTPM
Breast	41.5 nTPM
Bone marrow	36.0 nTPM
Spleen	32.5 nTPM
Liver	26.1 nTPM
PBMC	25.7 nTPM
Kidney	9.5 nTPM

Dendritic cells	55.7 nTPM
Adipose tissue	86.2 nTPM
Breast	64.9 nTPM
PBMC	16.0 nTPM

Endothelial cells	18.9 nTPM
Pancreas	42.5 nTPM
Skin	30.0 nTPM
Breast	27.7 nTPM
Lung	21.8 nTPM
Skeletal muscle	19.9 nTPM
Testis	19.8 nTPM
Esophagus	19.7 nTPM
Endometrium	17.8 nTPM
Ovary	16.6 nTPM
Eye	13.7 nTPM
Prostate	11.3 nTPM
Liver	9.2 nTPM
Placenta	9.1 nTPM
Heart muscle	5.7 nTPM

Fibroblasts	14.9 nTPM
Skin	25.6 nTPM
Breast	22.0 nTPM
Adipose tissue	20.0 nTPM
Stomach	19.3 nTPM
Lung	19.0 nTPM
Esophagus	16.6 nTPM
Skeletal muscle	14.3 nTPM
Ovary	10.0 nTPM
Placenta	8.6 nTPM
Prostate	7.4 nTPM
Heart muscle	0.7 nTPM

Intestinal goblet cells	23.2 nTPM
Colon	30.7 nTPM
Small intestine	25.2 nTPM
Rectum	13.6 nTPM

Macrophages	21.1 nTPM
Breast	42.4 nTPM
Adipose tissue	35.1 nTPM
Bone marrow	32.4 nTPM
Stomach	29.4 nTPM
Endometrium	24.3 nTPM
Esophagus	22.0 nTPM
Skeletal muscle	21.0 nTPM
Pancreas	20.4 nTPM
Ovary	15.5 nTPM
Testis	14.5 nTPM
Spleen	14.5 nTPM
PBMC	13.6 nTPM
Kidney	12.0 nTPM
Lung	10.3 nTPM
Prostate	9.1 nTPM

Paneth cells	35.9 nTPM
Colon	62.6 nTPM
Rectum	22.6 nTPM
Small intestine	22.5 nTPM

Plasma cells	42.2 nTPM
Adipose tissue	98.0 nTPM
Spleen	37.7 nTPM
Stomach	35.7 nTPM
Bone marrow	21.4 nTPM
Esophagus	18.4 nTPM

Respiratory ciliated cells	14.6 nTPM
Lung	20.4 nTPM
Bronchus	8.9 nTPM

Smooth muscle cells	18.8 nTPM
Breast	31.9 nTPM
Adipose tissue	30.1 nTPM
Endometrium	26.4 nTPM
Ovary	19.4 nTPM
Esophagus	18.6 nTPM
Skeletal muscle	18.5 nTPM
Skin	17.0 nTPM
Pancreas	15.8 nTPM
Bronchus	12.3 nTPM
Prostate	9.7 nTPM
Heart muscle	6.8 nTPM

T-cells	39.0 nTPM
Adipose tissue	90.4 nTPM
Breast	70.9 nTPM
Skeletal muscle	46.5 nTPM
Colon	43.7 nTPM
Endometrium	43.0 nTPM
Stomach	42.7 nTPM
Bone marrow	38.2 nTPM
Lymph node	34.6 nTPM
Spleen	34.2 nTPM
PBMC	32.0 nTPM
Lung	30.4 nTPM
Skin	29.9 nTPM
Liver	28.7 nTPM
Esophagus	26.2 nTPM
Ovary	24.5 nTPM
Kidney	24.0 nTPM
Prostate	23.6 nTPM

Basal prostatic cells	11.5 nTPM
Prostate	11.5 nTPM

Basal respiratory cells	11.4 nTPM
Bronchus	11.4 nTPM

Basal squamous epithelial cells	29.0 nTPM
Esophagus	29.0 nTPM

Cholangiocytes	17.2 nTPM
Liver	17.2 nTPM

Undifferentiated cells	21.8 nTPM
Colon	25.8 nTPM
Small intestine	22.3 nTPM
Rectum	17.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC