Single cell type - MPRIP - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MPRIP
Gene descriptionⁱ Full gene name according to HGNC.	Myosin phosphatase Rho interacting protein
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	14

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Smooth muscle cells - ECM organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (T-reg)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MPRIP is part of cluster 48 Smooth muscle cells - ECM organization with confidenceⁱ 1
270 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MCAM	Melanoma cell adhesion molecule	0.5574	48
FOXL1	Forkhead box L1	0.5508	48
NRIP2	Nuclear receptor interacting protein 2	0.5463	48
KLC1	Kinesin light chain 1	0.5281	62
FOXS1	Forkhead box S1	0.5262	48
SSTR2	Somatostatin receptor 2	0.5258	48
GJA4	Gap junction protein alpha 4	0.5235	48
ARHGEF17	Rho guanine nucleotide exchange factor 17	0.5231	48
NCKAP1	NCK associated protein 1	0.5174	44
TGFB1I1	Transforming growth factor beta 1 induced transcript 1	0.5151	48
RGS5	Regulator of G protein signaling 5	0.5130	48
TAGLN	Transgelin	0.5101	48
GJC1	Gap junction protein gamma 1	0.5101	48
CCDC3	Coiled-coil domain containing 3	0.5098	48
CSPG4	Chondroitin sulfate proteoglycan 4	0.5043	48

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	75.9 nTPM
Breast	83.5 nTPM
Adipose tissue	68.4 nTPM

Alveolar cells type 1	32.1 nTPM
Lung	32.1 nTPM

Alveolar cells type 2	48.0 nTPM
Lung	48.0 nTPM

Astrocytes	87.1 nTPM
Brain	87.1 nTPM

B-cells	22.2 nTPM
Adipose tissue	45.6 nTPM
Kidney	28.5 nTPM
Breast	28.1 nTPM
Spleen	21.1 nTPM
Lymph node	20.3 nTPM
Bone marrow	19.6 nTPM
Liver	19.5 nTPM
PBMC	18.6 nTPM
Colon	11.2 nTPM
Stomach	9.1 nTPM

Dendritic cells	32.9 nTPM
Adipose tissue	39.8 nTPM
Breast	35.0 nTPM
PBMC	23.9 nTPM

Endothelial cells	62.1 nTPM
Ovary	111.4 nTPM
Eye	92.2 nTPM
Pancreas	88.8 nTPM
Skeletal muscle	77.0 nTPM
Prostate	66.9 nTPM
Endometrium	63.6 nTPM
Heart muscle	59.8 nTPM
Breast	55.9 nTPM
Esophagus	48.3 nTPM
Liver	44.9 nTPM
Skin	43.5 nTPM
Testis	40.0 nTPM
Placenta	39.8 nTPM
Lung	37.4 nTPM

Fibroblasts	39.7 nTPM
Ovary	84.6 nTPM
Skin	44.8 nTPM
Lung	42.4 nTPM
Placenta	39.7 nTPM
Skeletal muscle	39.7 nTPM
Heart muscle	37.0 nTPM
Adipose tissue	35.0 nTPM
Prostate	33.2 nTPM
Breast	31.7 nTPM
Stomach	25.3 nTPM
Esophagus	23.3 nTPM

Intestinal goblet cells	17.3 nTPM
Rectum	22.4 nTPM
Small intestine	18.2 nTPM
Colon	11.4 nTPM

Macrophages	17.7 nTPM
Adipose tissue	55.7 nTPM
Skeletal muscle	33.2 nTPM
Endometrium	23.9 nTPM
Breast	20.8 nTPM
Esophagus	17.3 nTPM
Prostate	17.2 nTPM
Lung	16.5 nTPM
Testis	15.7 nTPM
PBMC	13.6 nTPM
Stomach	11.7 nTPM
Ovary	11.0 nTPM
Pancreas	10.2 nTPM
Bone marrow	7.5 nTPM
Spleen	6.2 nTPM
Kidney	5.3 nTPM

Paneth cells	26.4 nTPM
Rectum	30.2 nTPM
Colon	26.4 nTPM
Small intestine	22.5 nTPM

Plasma cells	19.0 nTPM
Adipose tissue	44.6 nTPM
Bone marrow	18.2 nTPM
Spleen	14.9 nTPM
Stomach	11.3 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	30.6 nTPM
Bronchus	35.0 nTPM
Lung	26.2 nTPM

Smooth muscle cells	110.4 nTPM
Skeletal muscle	181.5 nTPM
Breast	155.5 nTPM
Endometrium	146.1 nTPM
Heart muscle	139.5 nTPM
Adipose tissue	138.8 nTPM
Ovary	111.7 nTPM
Skin	107.7 nTPM
Esophagus	100.8 nTPM
Prostate	75.3 nTPM
Pancreas	44.7 nTPM
Bronchus	13.2 nTPM

T-cells	35.0 nTPM
Adipose tissue	62.4 nTPM
Ovary	60.1 nTPM
Colon	48.5 nTPM
Skin	48.3 nTPM
Skeletal muscle	47.8 nTPM
Breast	46.5 nTPM
Endometrium	42.4 nTPM
Liver	38.0 nTPM
PBMC	36.5 nTPM
Stomach	27.8 nTPM
Lymph node	26.5 nTPM
Kidney	25.3 nTPM
Bone marrow	24.5 nTPM
Spleen	24.1 nTPM
Lung	13.6 nTPM
Esophagus	13.1 nTPM
Prostate	9.5 nTPM

Basal keratinocytes	27.0 nTPM
Skin	27.0 nTPM

Basal prostatic cells	27.9 nTPM
Prostate	27.9 nTPM

Basal respiratory cells	22.7 nTPM
Bronchus	22.7 nTPM

Basal squamous epithelial cells	12.5 nTPM
Esophagus	12.5 nTPM

Undifferentiated cells	27.1 nTPM
Rectum	32.1 nTPM
Small intestine	26.7 nTPM
Colon	22.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC