Single cell type - IRAK2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	IRAK2
Gene descriptionⁱ Full gene name according to HGNC.	Interleukin 1 receptor associated kinase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Human disease related genes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Macrophages - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Langerhans cells, Oligodendrocytes, Urothelial cells, Prostatic glandular cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (BEWO, BJ hTERT+, CAPAN-2, GAMG, RT4)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Langerhans cells, Oligodendrocytes, Urothelial cells, Prostatic glandular cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

IRAK2 is part of cluster 41 Macrophages - Immune response with confidenceⁱ 1
307 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PIM3	Pim-3 proto-oncogene, serine/threonine kinase	0.6992	41
CFLAR	CASP8 and FADD like apoptosis regulator	0.6934	41
NFKB1	Nuclear factor kappa B subunit 1	0.6895	41
GNA13	G protein subunit alpha 13	0.6679	41
CXCL8	C-X-C motif chemokine ligand 8	0.6598	22
G0S2	G0/G1 switch 2	0.6596	41
MAP3K8	Mitogen-activated protein kinase kinase kinase 8	0.6561	41
SAT1	Spermidine/spermine N1-acetyltransferase 1	0.6549	26
LORICRIN	Loricrin cornified envelope precursor protein	0.6542	41
TNFRSF10B	TNF receptor superfamily member 10b	0.6536	44
PLAUR	Plasminogen activator, urokinase receptor	0.6531	41
RIPK2	Receptor interacting serine/threonine kinase 2	0.6484	41
INSIG1	Insulin induced gene 1	0.6477	41
NFKBID	NFKB inhibitor delta	0.6440	41
SERPINB9	Serpin family B member 9	0.6430	41

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	3.9 nTPM
Adipose tissue	5.1 nTPM
Breast	2.7 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	4.1 nTPM
Lung	4.1 nTPM

Astrocytes	1.6 nTPM
Brain	1.6 nTPM

B-cells	8.3 nTPM
Stomach	29.5 nTPM
Lymph node	13.0 nTPM
Colon	12.8 nTPM
Adipose tissue	11.5 nTPM
Spleen	7.2 nTPM
Bone marrow	4.9 nTPM
PBMC	2.8 nTPM
Liver	1.8 nTPM
Kidney	0.0 nTPM
Breast	0.0 nTPM

Dendritic cells	3.8 nTPM
Adipose tissue	5.8 nTPM
Breast	5.8 nTPM
PBMC	0.0 nTPM

Endothelial cells	12.3 nTPM
Prostate	83.7 nTPM
Skin	21.5 nTPM
Endometrium	14.8 nTPM
Lung	12.5 nTPM
Pancreas	11.6 nTPM
Esophagus	7.7 nTPM
Ovary	5.8 nTPM
Skeletal muscle	5.2 nTPM
Breast	2.8 nTPM
Placenta	2.2 nTPM
Testis	2.1 nTPM
Heart muscle	1.1 nTPM
Liver	0.9 nTPM
Eye	0.8 nTPM

Fibroblasts	4.3 nTPM
Prostate	18.2 nTPM
Stomach	13.4 nTPM
Skin	7.6 nTPM
Skeletal muscle	2.3 nTPM
Esophagus	1.9 nTPM
Lung	1.2 nTPM
Breast	1.1 nTPM
Adipose tissue	0.8 nTPM
Heart muscle	0.2 nTPM
Placenta	0.2 nTPM
Ovary	0.2 nTPM

Intestinal goblet cells	0.7 nTPM
Rectum	2.3 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Macrophages	20.9 nTPM
Adipose tissue	73.2 nTPM
Stomach	64.5 nTPM
Prostate	45.8 nTPM
Endometrium	23.2 nTPM
Esophagus	20.4 nTPM
Breast	20.2 nTPM
Spleen	19.7 nTPM
Skeletal muscle	17.9 nTPM
PBMC	13.6 nTPM
Testis	5.2 nTPM
Kidney	4.6 nTPM
Lung	2.1 nTPM
Ovary	1.8 nTPM
Bone marrow	1.2 nTPM
Pancreas	0.0 nTPM

Paneth cells	0.3 nTPM
Rectum	0.9 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	7.4 nTPM
Esophagus	12.3 nTPM
Stomach	9.4 nTPM
Adipose tissue	6.4 nTPM
Spleen	5.6 nTPM
Bone marrow	3.3 nTPM

Respiratory ciliated cells	1.3 nTPM
Bronchus	2.6 nTPM
Lung	0.0 nTPM

Smooth muscle cells	2.0 nTPM
Prostate	8.8 nTPM
Skin	4.9 nTPM
Pancreas	2.6 nTPM
Endometrium	1.6 nTPM
Heart muscle	1.2 nTPM
Bronchus	1.0 nTPM
Breast	0.8 nTPM
Ovary	0.4 nTPM
Skeletal muscle	0.2 nTPM
Adipose tissue	0.2 nTPM
Esophagus	0.0 nTPM

T-cells	3.9 nTPM
Prostate	9.5 nTPM
Endometrium	7.6 nTPM
Ovary	6.7 nTPM
Liver	6.3 nTPM
Spleen	5.3 nTPM
Breast	5.0 nTPM
Bone marrow	4.5 nTPM
Adipose tissue	4.2 nTPM
Lymph node	3.7 nTPM
Stomach	3.4 nTPM
Skin	2.8 nTPM
PBMC	2.3 nTPM
Skeletal muscle	2.0 nTPM
Lung	1.5 nTPM
Colon	1.4 nTPM
Kidney	0.0 nTPM
Esophagus	0.0 nTPM

Basal keratinocytes	8.0 nTPM
Skin	8.0 nTPM

Basal prostatic cells	20.8 nTPM
Prostate	20.8 nTPM

Basal respiratory cells	9.9 nTPM
Bronchus	9.9 nTPM

Endometrial stromal cells	2.4 nTPM
Endometrium	2.4 nTPM

Undifferentiated cells	0.5 nTPM
Colon	0.7 nTPM
Rectum	0.7 nTPM
Small intestine	0.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC