Single cell type - CXCL8 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CXCL8
Gene descriptionⁱ Full gene name according to HGNC.	C-X-C motif chemokine ligand 8
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Candidate cardiovascular disease genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Epithelial cell types - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Basal prostatic cells, Urothelial cells, Prostatic glandular cells, Macrophages)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enriched (neutrophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Group enriched (BJ hTERT+, GAMG)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Basal prostatic cells, Urothelial cells, Prostatic glandular cells, Macrophages)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CXCL8 is part of cluster 22 Epithelial cell types - Mixed function with confidenceⁱ 1
298 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
KRTAP3-1	Keratin associated protein 3-1	0.8477	22
KRT17	Keratin 17	0.8470	22
KRTAP4-12	Keratin associated protein 4-12	0.8275	22
RNASE7	Ribonuclease A family member 7	0.8252	22
KRTAP1-1	Keratin associated protein 1-1	0.7975	22
FOSL1	FOS like 1, AP-1 transcription factor subunit	0.7878	22
HSPB1	Heat shock protein family B (small) member 1	0.7831	22
HSP90AA1	Heat shock protein 90 alpha family class A member 1	0.7827	22
BAG3	BAG cochaperone 3	0.7724	22
PLAT	Plasminogen activator, tissue type	0.7669	22
HSPH1	Heat shock protein family H (Hsp110) member 1	0.7529	22
GADD45A	Growth arrest and DNA damage inducible alpha	0.7477	22
PLAUR	Plasminogen activator, urokinase receptor	0.7445	41
TXNRD1	Thioredoxin reductase 1	0.7434	22
TM4SF1	Transmembrane 4 L six family member 1	0.7361	22

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	28.6 nTPM
Breast	34.5 nTPM
Adipose tissue	22.7 nTPM

Alveolar cells type 1	51.3 nTPM
Lung	51.3 nTPM

Alveolar cells type 2	254.1 nTPM
Lung	254.1 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	26.4 nTPM
Colon	167.7 nTPM
Adipose tissue	43.7 nTPM
Spleen	16.2 nTPM
Breast	13.4 nTPM
Lymph node	9.8 nTPM
Liver	6.7 nTPM
Kidney	4.8 nTPM
Stomach	1.8 nTPM
PBMC	0.0 nTPM
Bone marrow	0.0 nTPM

Basal squamous epithelial cells	164.4 nTPM
Esophagus	164.4 nTPM

Dendritic cells	17.7 nTPM
Adipose tissue	48.0 nTPM
Breast	5.1 nTPM
PBMC	0.0 nTPM

Endothelial cells	712.2 nTPM
Prostate	8628.3 nTPM
Pancreas	648.6 nTPM
Eye	337.4 nTPM
Endometrium	108.1 nTPM
Lung	84.2 nTPM
Skeletal muscle	75.3 nTPM
Placenta	23.9 nTPM
Esophagus	17.6 nTPM
Liver	16.5 nTPM
Breast	13.9 nTPM
Heart muscle	10.8 nTPM
Ovary	4.7 nTPM
Testis	1.4 nTPM
Skin	0.0 nTPM

Fibroblasts	1475.1 nTPM
Prostate	15433.2 nTPM
Lung	280.4 nTPM
Skeletal muscle	272.0 nTPM
Stomach	124.7 nTPM
Esophagus	35.0 nTPM
Adipose tissue	33.0 nTPM
Heart muscle	24.0 nTPM
Placenta	15.5 nTPM
Breast	8.5 nTPM
Ovary	0.3 nTPM
Skin	0.0 nTPM

Glandular and luminal cells	1708.7 nTPM
Endometrium	1708.7 nTPM

Intestinal goblet cells	26.4 nTPM
Colon	75.8 nTPM
Rectum	3.6 nTPM
Small intestine	0.0 nTPM

Macrophages	3685.4 nTPM
Prostate	14659.3 nTPM
Adipose tissue	12957.6 nTPM
Pancreas	10773.5 nTPM
Endometrium	4097.1 nTPM
Skeletal muscle	2731.9 nTPM
Testis	2484.1 nTPM
Breast	1972.4 nTPM
Spleen	1863.2 nTPM
Esophagus	1625.5 nTPM
Stomach	1538.4 nTPM
Lung	316.2 nTPM
Kidney	168.6 nTPM
Ovary	77.9 nTPM
Bone marrow	15.0 nTPM
PBMC	0.0 nTPM

Paneth cells	0.3 nTPM
Rectum	0.9 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	27.3 nTPM
Adipose tissue	131.7 nTPM
Spleen	2.9 nTPM
Stomach	1.7 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM

Respiratory ciliated cells	178.6 nTPM
Lung	357.1 nTPM
Bronchus	0.0 nTPM

Cholangiocytes	127.2 nTPM
Liver	127.2 nTPM

Cytotrophoblasts	4.3 nTPM
Placenta	4.3 nTPM

Early spermatids	3.2 nTPM
Testis	3.2 nTPM

Endometrial stromal cells	257.1 nTPM
Endometrium	257.1 nTPM

Smooth muscle cells	263.0 nTPM
Prostate	2034.7 nTPM
Pancreas	431.2 nTPM
Skeletal muscle	202.7 nTPM
Endometrium	109.6 nTPM
Adipose tissue	36.1 nTPM
Ovary	31.3 nTPM
Heart muscle	19.5 nTPM
Esophagus	14.0 nTPM
Breast	13.7 nTPM
Skin	0.0 nTPM
Bronchus	0.0 nTPM

T-cells	138.8 nTPM
Prostate	1950.4 nTPM
Endometrium	227.2 nTPM
Lung	86.6 nTPM
Adipose tissue	39.8 nTPM
Skeletal muscle	19.1 nTPM
Spleen	12.5 nTPM
Breast	6.7 nTPM
Esophagus	6.6 nTPM
Liver	5.3 nTPM
Colon	1.9 nTPM
Lymph node	0.9 nTPM
Stomach	0.9 nTPM
Kidney	0.7 nTPM
Bone marrow	0.1 nTPM
PBMC	0.0 nTPM
Skin	0.0 nTPM
Ovary	0.0 nTPM

Undifferentiated cells	18.5 nTPM
Colon	53.4 nTPM
Rectum	1.6 nTPM
Small intestine	0.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC