Single cell type - SLC43A3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SLC43A3
Gene descriptionⁱ Full gene name according to HGNC.	Solute carrier family 43 member 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	21

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Macrophages - Innate immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Ductal cells, Langerhans cells, Hofbauer cells, granulocytes, Sertoli cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (non-classical monocyte, intermediate monocyte, classical monocyte, myeloid DC, plasmacytoid DC)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HL-60, HMC-1, RPMI-8226, WM-115)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Ductal cells, Langerhans cells, Hofbauer cells, granulocytes, Sertoli cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

SLC43A3 is part of cluster 4 Macrophages - Innate immune response with confidenceⁱ 1
228 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TBXT	T-box transcription factor T	0.6081	4
OR5AN1	Olfactory receptor family 5 subfamily AN member 1	0.5866	4
CHI3L1	Chitinase 3 like 1	0.5846	4
PROCR	Protein C receptor	0.5657	50
GPNMB	Glycoprotein nmb	0.5634	4
CFH	Complement factor H	0.5324	50
GUSB	Glucuronidase beta	0.5172	4
C1S	Complement C1s	0.5162	2
MMP9	Matrix metallopeptidase 9	0.5146	4
CSF1	Colony stimulating factor 1	0.5098	50
AL159163.1	Novel protein	0.5086	4
PSAP	Prosaposin	0.5082	4
DCSTAMP	Dendrocyte expressed seven transmembrane protein	0.5069	4
C3	Complement C3	0.5020	15
TMEM255B	Transmembrane protein 255B	0.4903	14

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	19.8 nTPM
Breast	23.6 nTPM
Adipose tissue	16.2 nTPM

Alveolar cells type 1	16.0 nTPM
Lung	16.0 nTPM

Alveolar cells type 2	49.1 nTPM
Lung	49.1 nTPM

Astrocytes	1.6 nTPM
Brain	1.6 nTPM

B-cells	6.1 nTPM
Liver	30.5 nTPM
Colon	9.6 nTPM
Spleen	5.2 nTPM
Stomach	5.0 nTPM
Lymph node	3.6 nTPM
PBMC	2.8 nTPM
Bone marrow	1.7 nTPM
Adipose tissue	1.5 nTPM
Breast	1.3 nTPM
Kidney	0.0 nTPM

Dendritic cells	11.9 nTPM
PBMC	27.9 nTPM
Breast	5.8 nTPM
Adipose tissue	2.1 nTPM

Endothelial cells	33.0 nTPM
Prostate	83.4 nTPM
Pancreas	69.5 nTPM
Ovary	47.2 nTPM
Skin	41.1 nTPM
Esophagus	30.2 nTPM
Eye	28.3 nTPM
Endometrium	27.4 nTPM
Breast	25.2 nTPM
Lung	24.9 nTPM
Placenta	22.7 nTPM
Testis	22.2 nTPM
Skeletal muscle	20.2 nTPM
Heart muscle	14.5 nTPM
Liver	5.5 nTPM

Fibroblasts	33.4 nTPM
Adipose tissue	79.1 nTPM
Skeletal muscle	53.5 nTPM
Esophagus	53.3 nTPM
Prostate	36.8 nTPM
Skin	33.4 nTPM
Breast	31.7 nTPM
Stomach	19.3 nTPM
Heart muscle	18.3 nTPM
Lung	17.9 nTPM
Placenta	12.4 nTPM
Ovary	11.7 nTPM

Intestinal goblet cells	0.6 nTPM
Rectum	1.0 nTPM
Small intestine	0.8 nTPM
Colon	0.0 nTPM

Macrophages	47.0 nTPM
Pancreas	102.0 nTPM
Prostate	75.7 nTPM
Esophagus	59.8 nTPM
Testis	59.2 nTPM
Lung	54.7 nTPM
Stomach	52.7 nTPM
Adipose tissue	50.7 nTPM
Kidney	49.1 nTPM
Skeletal muscle	37.8 nTPM
Ovary	32.6 nTPM
Spleen	32.1 nTPM
Endometrium	30.8 nTPM
Bone marrow	30.0 nTPM
Breast	24.0 nTPM
PBMC	13.6 nTPM

Paneth cells	0.5 nTPM
Rectum	1.6 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	22.5 nTPM
Bone marrow	49.4 nTPM
Spleen	33.8 nTPM
Esophagus	12.3 nTPM
Stomach	9.1 nTPM
Adipose tissue	7.8 nTPM

Respiratory ciliated cells	4.9 nTPM
Lung	5.8 nTPM
Bronchus	3.9 nTPM

Smooth muscle cells	22.0 nTPM
Skeletal muscle	49.0 nTPM
Breast	32.3 nTPM
Adipose tissue	27.6 nTPM
Esophagus	24.8 nTPM
Prostate	23.7 nTPM
Skin	20.6 nTPM
Heart muscle	20.3 nTPM
Ovary	19.6 nTPM
Pancreas	12.6 nTPM
Endometrium	9.1 nTPM
Bronchus	2.8 nTPM

T-cells	11.8 nTPM
Skin	28.1 nTPM
Lung	25.8 nTPM
Prostate	23.6 nTPM
Stomach	18.0 nTPM
Liver	12.2 nTPM
Colon	11.4 nTPM
Breast	11.4 nTPM
Bone marrow	10.0 nTPM
Spleen	9.6 nTPM
Ovary	8.9 nTPM
Kidney	7.5 nTPM
Skeletal muscle	7.0 nTPM
Lymph node	7.0 nTPM
Endometrium	6.7 nTPM
Esophagus	6.6 nTPM
PBMC	4.3 nTPM
Adipose tissue	2.9 nTPM

Basal keratinocytes	46.8 nTPM
Skin	46.8 nTPM

Basal prostatic cells	7.4 nTPM
Prostate	7.4 nTPM

Basal squamous epithelial cells	48.3 nTPM
Esophagus	48.3 nTPM

Cholangiocytes	28.6 nTPM
Liver	28.6 nTPM

Undifferentiated cells	1.2 nTPM
Rectum	2.1 nTPM
Colon	1.4 nTPM
Small intestine	0.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC