Single cell type - OS9 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	OS9
Gene descriptionⁱ Full gene name according to HGNC.	OS9 endoplasmic reticulum lectin
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	11

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Plasma cells - Humoral immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enriched (RH-30)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

OS9 is part of cluster 55 Plasma cells - Humoral immune response with confidenceⁱ 0.93
379 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
GUSB	Glucuronidase beta	0.5630	4
HM13	Histocompatibility minor 13	0.5563	55
DDOST	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	0.5514	55
RRBP1	Ribosome binding protein 1	0.5462	53
YIPF3	Yip1 domain family member 3	0.5064	55
SLC39A7	Solute carrier family 39 member 7	0.4914	27
SLC38A10	Solute carrier family 38 member 10	0.4881	55
PDIA3	Protein disulfide isomerase family A member 3	0.4877	55
PDIA4	Protein disulfide isomerase family A member 4	0.4873	55
ATP6AP1	ATPase H+ transporting accessory protein 1	0.4773	4
RPN2	Ribophorin II	0.4741	55
GRN	Granulin precursor	0.4738	4
ERP44	Endoplasmic reticulum protein 44	0.4668	55
SIL1	SIL1 nucleotide exchange factor	0.4656	55
CLPTM1	CLPTM1 regulator of GABA type A receptor forward trafficking	0.4599	55

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	83.3 nTPM
Adipose tissue	84.9 nTPM
Breast	81.7 nTPM

Alveolar cells type 1	86.6 nTPM
Lung	86.6 nTPM

Alveolar cells type 2	116.7 nTPM
Lung	116.7 nTPM

Astrocytes	22.2 nTPM
Brain	22.2 nTPM

B-cells	65.8 nTPM
Liver	146.7 nTPM
Breast	112.4 nTPM
Kidney	66.6 nTPM
PBMC	62.8 nTPM
Bone marrow	52.3 nTPM
Colon	51.1 nTPM
Lymph node	50.3 nTPM
Stomach	46.7 nTPM
Spleen	34.6 nTPM
Adipose tissue	34.5 nTPM

Dendritic cells	64.5 nTPM
PBMC	79.7 nTPM
Adipose tissue	60.3 nTPM
Breast	53.5 nTPM

Endothelial cells	90.2 nTPM
Lung	174.6 nTPM
Pancreas	135.1 nTPM
Ovary	110.9 nTPM
Placenta	110.8 nTPM
Testis	104.6 nTPM
Liver	93.6 nTPM
Eye	81.7 nTPM
Esophagus	80.5 nTPM
Skin	78.9 nTPM
Skeletal muscle	76.3 nTPM
Breast	71.4 nTPM
Endometrium	67.9 nTPM
Prostate	57.5 nTPM
Heart muscle	18.5 nTPM

Enteroendocrine cells	103.6 nTPM
Colon	110.1 nTPM
Rectum	97.1 nTPM

Fibroblasts	113.6 nTPM
Adipose tissue	158.3 nTPM
Esophagus	155.1 nTPM
Stomach	150.0 nTPM
Placenta	143.6 nTPM
Skin	130.5 nTPM
Breast	110.9 nTPM
Skeletal muscle	110.6 nTPM
Lung	103.9 nTPM
Prostate	81.6 nTPM
Ovary	72.4 nTPM
Heart muscle	32.8 nTPM

Intestinal goblet cells	167.3 nTPM
Colon	271.6 nTPM
Rectum	122.6 nTPM
Small intestine	107.7 nTPM

Macrophages	106.1 nTPM
Lung	192.3 nTPM
Pancreas	163.4 nTPM
Testis	147.0 nTPM
Ovary	136.9 nTPM
Adipose tissue	115.8 nTPM
Kidney	105.8 nTPM
Stomach	99.6 nTPM
Prostate	98.6 nTPM
Bone marrow	94.9 nTPM
Skeletal muscle	92.2 nTPM
Breast	91.2 nTPM
Spleen	86.0 nTPM
Endometrium	81.3 nTPM
Esophagus	72.4 nTPM
PBMC	13.6 nTPM

Paneth cells	155.4 nTPM
Colon	204.2 nTPM
Small intestine	138.9 nTPM
Rectum	123.3 nTPM

Plasma cells	141.1 nTPM
Stomach	225.6 nTPM
Esophagus	154.1 nTPM
Spleen	130.0 nTPM
Adipose tissue	105.1 nTPM
Bone marrow	90.6 nTPM

Respiratory ciliated cells	74.0 nTPM
Lung	102.0 nTPM
Bronchus	46.1 nTPM

Smooth muscle cells	66.9 nTPM
Pancreas	135.1 nTPM
Prostate	77.3 nTPM
Adipose tissue	75.7 nTPM
Ovary	72.3 nTPM
Bronchus	67.1 nTPM
Skeletal muscle	64.0 nTPM
Breast	63.3 nTPM
Skin	55.8 nTPM
Esophagus	55.8 nTPM
Endometrium	51.4 nTPM
Heart muscle	18.4 nTPM

Basal keratinocytes	57.7 nTPM
Skin	57.7 nTPM

Basal prostatic cells	85.4 nTPM
Prostate	85.4 nTPM

Basal respiratory cells	103.3 nTPM
Bronchus	103.3 nTPM

Basal squamous epithelial cells	43.9 nTPM
Esophagus	43.9 nTPM

T-cells	59.5 nTPM
Lung	124.6 nTPM
Kidney	82.2 nTPM
Prostate	75.7 nTPM
Liver	72.7 nTPM
Stomach	64.5 nTPM
Skeletal muscle	61.5 nTPM
Skin	59.4 nTPM
Colon	58.5 nTPM
Ovary	57.8 nTPM
Bone marrow	56.5 nTPM
Breast	52.6 nTPM
Adipose tissue	51.3 nTPM
Spleen	45.7 nTPM
Lymph node	45.2 nTPM
PBMC	44.6 nTPM
Endometrium	38.9 nTPM
Esophagus	19.7 nTPM

Undifferentiated cells	102.4 nTPM
Colon	130.5 nTPM
Rectum	94.3 nTPM
Small intestine	82.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC