Single cell type - TMBIM1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TMBIM1
Gene descriptionⁱ Full gene name according to HGNC.	Transmembrane BAX inhibitor motif containing 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	16

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Intestinal epithelial cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Urothelial cells, Pancreatic endocrine cells, Syncytiotrophoblasts, Exocrine glandular cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (RT4)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Urothelial cells, Pancreatic endocrine cells, Syncytiotrophoblasts, Exocrine glandular cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TMBIM1 is part of cluster 53 Intestinal epithelial cells - Unknown function with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TAX1BP3	Tax1 binding protein 3	0.7923	53
CLTB	Clathrin light chain B	0.7512	16
LRP10	LDL receptor related protein 10	0.7489	53
RHOD	Ras homolog family member D	0.7480	16
RHOC	Ras homolog family member C	0.7379	16
SDCBP2	Syndecan binding protein 2	0.7265	16
PPARD	Peroxisome proliferator activated receptor delta	0.7240	53
LSR	Lipolysis stimulated lipoprotein receptor	0.7204	53
DUOX2	Dual oxidase 2	0.7180	16
MALL	Mal, T cell differentiation protein like	0.7085	53
CRB3	Crumbs cell polarity complex component 3	0.7010	53
CLDN7	Claudin 7	0.6577	53
PRSS3	Serine protease 3	0.6575	53
GBP3	Guanylate binding protein 3	0.6566	53
CHMP4B	Charged multivesicular body protein 4B	0.6503	53

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	47.6 nTPM
Adipose tissue	54.6 nTPM
Breast	40.5 nTPM

Alveolar cells type 1	73.7 nTPM
Lung	73.7 nTPM

Alveolar cells type 2	25.6 nTPM
Lung	25.6 nTPM

Astrocytes	20.9 nTPM
Brain	20.9 nTPM

B-cells	37.2 nTPM
Kidney	66.6 nTPM
Adipose tissue	53.1 nTPM
Colon	46.4 nTPM
Stomach	45.4 nTPM
PBMC	32.9 nTPM
Lymph node	29.5 nTPM
Bone marrow	29.4 nTPM
Spleen	26.3 nTPM
Breast	22.8 nTPM
Liver	19.9 nTPM

Dendritic cells	51.8 nTPM
Adipose tissue	80.1 nTPM
Breast	67.4 nTPM
PBMC	8.0 nTPM

Endothelial cells	50.8 nTPM
Prostate	98.4 nTPM
Skin	78.3 nTPM
Esophagus	77.5 nTPM
Skeletal muscle	52.2 nTPM
Placenta	49.5 nTPM
Lung	46.8 nTPM
Breast	46.7 nTPM
Pancreas	46.4 nTPM
Liver	41.2 nTPM
Heart muscle	40.2 nTPM
Testis	39.4 nTPM
Eye	37.2 nTPM
Ovary	31.3 nTPM
Endometrium	26.4 nTPM

Fibroblasts	61.9 nTPM
Prostate	118.6 nTPM
Adipose tissue	94.4 nTPM
Placenta	84.4 nTPM
Esophagus	80.6 nTPM
Skin	72.3 nTPM
Stomach	60.9 nTPM
Skeletal muscle	56.2 nTPM
Breast	37.8 nTPM
Lung	35.7 nTPM
Heart muscle	26.3 nTPM
Ovary	13.6 nTPM

Intestinal goblet cells	67.9 nTPM
Colon	81.4 nTPM
Small intestine	74.1 nTPM
Rectum	48.1 nTPM

Macrophages	69.6 nTPM
PBMC	231.9 nTPM
Pancreas	145.5 nTPM
Ovary	75.4 nTPM
Adipose tissue	75.0 nTPM
Prostate	66.4 nTPM
Testis	66.2 nTPM
Lung	61.5 nTPM
Stomach	58.6 nTPM
Skeletal muscle	49.6 nTPM
Esophagus	40.9 nTPM
Spleen	39.4 nTPM
Kidney	38.6 nTPM
Bone marrow	36.3 nTPM
Breast	29.9 nTPM
Endometrium	28.4 nTPM

Paneth cells	177.3 nTPM
Colon	329.4 nTPM
Small intestine	112.7 nTPM
Rectum	89.9 nTPM

Plasma cells	30.3 nTPM
Adipose tissue	67.1 nTPM
Stomach	35.7 nTPM
Esophagus	24.6 nTPM
Bone marrow	14.8 nTPM
Spleen	9.1 nTPM

Respiratory ciliated cells	34.8 nTPM
Bronchus	60.9 nTPM
Lung	8.7 nTPM

Smooth muscle cells	45.0 nTPM
Prostate	112.2 nTPM
Pancreas	68.3 nTPM
Esophagus	62.0 nTPM
Skin	48.1 nTPM
Adipose tissue	43.5 nTPM
Skeletal muscle	39.5 nTPM
Breast	33.3 nTPM
Heart muscle	24.6 nTPM
Bronchus	22.5 nTPM
Endometrium	21.1 nTPM
Ovary	19.7 nTPM

T-cells	41.3 nTPM
Adipose tissue	69.1 nTPM
Skin	63.0 nTPM
Skeletal muscle	51.7 nTPM
Colon	49.9 nTPM
Kidney	48.0 nTPM
Ovary	46.7 nTPM
Bone marrow	43.3 nTPM
Spleen	43.1 nTPM
Esophagus	39.3 nTPM
Prostate	37.9 nTPM
PBMC	35.7 nTPM
Breast	33.0 nTPM
Endometrium	32.5 nTPM
Stomach	32.5 nTPM
Lymph node	28.6 nTPM
Liver	27.6 nTPM
Lung	19.7 nTPM

Basal keratinocytes	81.7 nTPM
Skin	81.7 nTPM

Basal prostatic cells	96.9 nTPM
Prostate	96.9 nTPM

Basal respiratory cells	85.0 nTPM
Bronchus	85.0 nTPM

Cholangiocytes	78.6 nTPM
Liver	78.6 nTPM

Undifferentiated cells	69.1 nTPM
Colon	114.4 nTPM
Rectum	47.5 nTPM
Small intestine	45.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC