Single cell type - RNASEH2B - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RNASEH2B
Gene descriptionⁱ Full gene name according to HGNC.	Ribonuclease H2 subunit B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	26

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	B-cells - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (MOLT-4, NB-4, REH, THP-1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

RNASEH2B is part of cluster 57 B-cells - Immune response with confidenceⁱ 1
204 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CD180	CD180 molecule	0.5670	57
DPH5	Diphthamide biosynthesis 5	0.5277	32
SAAL1	Serum amyloid A like 1	0.5256	12
IGLC7	Immunoglobulin lambda constant 7	0.5017	55
NSUN5	NOP2/Sun RNA methyltransferase 5	0.4853	52
CNPY3	Canopy FGF signaling regulator 3	0.4845	57
RAD51AP1	RAD51 associated protein 1	0.4790	12
ERP29	Endoplasmic reticulum protein 29	0.4779	55
RNASE6	Ribonuclease A family member k6	0.4689	41
IGLV8-61	Immunoglobulin lambda variable 8-61	0.4684	55
NDC80	NDC80 kinetochore complex component	0.4665	12
EEF1B2	Eukaryotic translation elongation factor 1 beta 2	0.4593	32
GPSM3	G protein signaling modulator 3	0.4581	63
UCP2	Uncoupling protein 2	0.4553	6
PNOC	Prepronociceptin	0.4547	57

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	21.2 nTPM
Breast	22.7 nTPM
Adipose tissue	19.6 nTPM

Alveolar cells type 1	38.5 nTPM
Lung	38.5 nTPM

Alveolar cells type 2	23.8 nTPM
Lung	23.8 nTPM

Astrocytes	17.6 nTPM
Brain	17.6 nTPM

Basal keratinocytes	18.7 nTPM
Skin	18.7 nTPM

B-cells	85.8 nTPM
PBMC	128.5 nTPM
Kidney	119.0 nTPM
Bone marrow	98.9 nTPM
Liver	96.8 nTPM
Spleen	83.0 nTPM
Lymph node	74.5 nTPM
Stomach	72.7 nTPM
Adipose tissue	72.2 nTPM
Breast	65.6 nTPM
Colon	46.4 nTPM

Dendritic cells	92.3 nTPM
PBMC	163.4 nTPM
Breast	61.6 nTPM
Adipose tissue	51.8 nTPM

Endothelial cells	14.9 nTPM
Breast	23.0 nTPM
Placenta	22.1 nTPM
Ovary	21.6 nTPM
Lung	15.6 nTPM
Pancreas	15.5 nTPM
Testis	15.1 nTPM
Endometrium	13.9 nTPM
Skeletal muscle	13.5 nTPM
Prostate	12.9 nTPM
Heart muscle	12.8 nTPM
Eye	11.3 nTPM
Liver	11.0 nTPM
Skin	10.9 nTPM
Esophagus	9.3 nTPM

Erythroid cells	107.7 nTPM
Bone marrow	108.4 nTPM
Liver	107.0 nTPM

Fibroblasts	26.7 nTPM
Ovary	42.3 nTPM
Breast	40.2 nTPM
Placenta	39.9 nTPM
Adipose tissue	33.9 nTPM
Skeletal muscle	26.8 nTPM
Lung	24.6 nTPM
Skin	22.2 nTPM
Esophagus	19.8 nTPM
Prostate	19.2 nTPM
Heart muscle	12.7 nTPM
Stomach	11.9 nTPM

Intestinal goblet cells	21.8 nTPM
Rectum	31.7 nTPM
Small intestine	18.6 nTPM
Colon	15.0 nTPM

Macrophages	50.4 nTPM
Ovary	131.1 nTPM
Spleen	71.6 nTPM
Testis	66.2 nTPM
Breast	63.6 nTPM
Skeletal muscle	53.2 nTPM
Adipose tissue	52.4 nTPM
Kidney	50.6 nTPM
Endometrium	47.9 nTPM
Pancreas	43.4 nTPM
Lung	37.8 nTPM
Prostate	36.7 nTPM
Bone marrow	31.2 nTPM
Esophagus	29.9 nTPM
Stomach	26.4 nTPM
PBMC	13.6 nTPM

Paneth cells	9.9 nTPM
Rectum	26.0 nTPM
Small intestine	3.7 nTPM
Colon	0.0 nTPM

Plasma cells	75.6 nTPM
Spleen	114.1 nTPM
Stomach	80.9 nTPM
Esophagus	74.0 nTPM
Bone marrow	62.6 nTPM
Adipose tissue	46.4 nTPM

Respiratory ciliated cells	37.3 nTPM
Lung	58.3 nTPM
Bronchus	16.3 nTPM

Collecting duct cells	16.5 nTPM
Kidney	16.5 nTPM

Cone photoreceptor cells	6.2 nTPM
Eye	6.2 nTPM

Cytotrophoblasts	40.7 nTPM
Placenta	40.7 nTPM

Distal tubular cells	29.4 nTPM
Kidney	29.4 nTPM

Smooth muscle cells	28.9 nTPM
Bronchus	43.3 nTPM
Endometrium	38.0 nTPM
Ovary	37.2 nTPM
Pancreas	34.6 nTPM
Heart muscle	28.3 nTPM
Prostate	27.2 nTPM
Breast	27.2 nTPM
Adipose tissue	26.5 nTPM
Esophagus	23.3 nTPM
Skeletal muscle	20.7 nTPM
Skin	11.8 nTPM

T-cells	56.5 nTPM
PBMC	87.8 nTPM
Kidney	82.2 nTPM
Ovary	69.0 nTPM
Breast	66.2 nTPM
Spleen	64.0 nTPM
Colon	62.2 nTPM
Liver	58.7 nTPM
Lymph node	58.1 nTPM
Stomach	57.5 nTPM
Bone marrow	57.4 nTPM
Adipose tissue	50.9 nTPM
Lung	50.1 nTPM
Skeletal muscle	49.2 nTPM
Esophagus	45.9 nTPM
Endometrium	39.2 nTPM
Skin	34.0 nTPM
Prostate	28.4 nTPM

Undifferentiated cells	35.4 nTPM
Small intestine	47.5 nTPM
Rectum	37.1 nTPM
Colon	21.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC