Single cell type - DAB2IP - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DAB2IP
Gene descriptionⁱ Full gene name according to HGNC.	DAB2 interacting protein
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Endometrium - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected in immune cells
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Not detected
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HaCaT, HDLM-2)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

DAB2IP is part of cluster 44 Endometrium - Transcription with confidenceⁱ 1
491 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MECOM	MDS1 and EVI1 complex locus	0.5311	44
MYO10	Myosin X	0.5308	40
RAVER2	Ribonucleoprotein, PTB binding 2	0.5097	53
NCKAP1	NCK associated protein 1	0.4953	44
MCF2L	MCF.2 cell line derived transforming sequence like	0.4785	14
JAG2	Jagged canonical Notch ligand 2	0.4641	14
ADGRF2	Adhesion G protein-coupled receptor F2	0.4586	44
PCDH1	Protocadherin 1	0.4513	53
BAHD1	Bromo adjacent homology domain containing 1	0.4495	53
LGR4	Leucine rich repeat containing G protein-coupled receptor 4	0.4494	44
TMEM184B	Transmembrane protein 184B	0.4484	55
FZD8	Frizzled class receptor 8	0.4441	5
BMPR2	Bone morphogenetic protein receptor type 2	0.4432	40
CMTM4	CKLF like MARVEL transmembrane domain containing 4	0.4432	40
CFTR	CF transmembrane conductance regulator	0.4388	1

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	39.4 nTPM
Adipose tissue	47.7 nTPM
Breast	31.1 nTPM

Alveolar cells type 1	44.8 nTPM
Lung	44.8 nTPM

Alveolar cells type 2	11.7 nTPM
Lung	11.7 nTPM

Astrocytes	21.9 nTPM
Brain	21.9 nTPM

B-cells	1.1 nTPM
Kidney	4.8 nTPM
Colon	3.2 nTPM
Stomach	1.4 nTPM
Liver	0.9 nTPM
Adipose tissue	0.5 nTPM
Lymph node	0.3 nTPM
Spleen	0.3 nTPM
PBMC	0.0 nTPM
Bone marrow	0.0 nTPM
Breast	0.0 nTPM

Dendritic cells	0.6 nTPM
Breast	1.1 nTPM
Adipose tissue	0.6 nTPM
PBMC	0.0 nTPM

Endothelial cells	29.3 nTPM
Heart muscle	86.8 nTPM
Skeletal muscle	69.3 nTPM
Ovary	33.0 nTPM
Esophagus	28.9 nTPM
Prostate	25.7 nTPM
Lung	24.9 nTPM
Breast	23.0 nTPM
Testis	21.4 nTPM
Skin	20.7 nTPM
Eye	20.3 nTPM
Endometrium	19.8 nTPM
Liver	16.5 nTPM
Placenta	11.9 nTPM
Pancreas	7.7 nTPM

Fibroblasts	11.4 nTPM
Heart muscle	30.8 nTPM
Ovary	21.4 nTPM
Prostate	13.3 nTPM
Skin	11.1 nTPM
Stomach	10.4 nTPM
Placenta	9.7 nTPM
Skeletal muscle	9.7 nTPM
Breast	6.5 nTPM
Esophagus	5.7 nTPM
Adipose tissue	5.4 nTPM
Lung	1.2 nTPM

Intestinal goblet cells	17.2 nTPM
Rectum	26.4 nTPM
Small intestine	15.3 nTPM
Colon	10.0 nTPM

Macrophages	1.2 nTPM
Endometrium	4.8 nTPM
Kidney	3.8 nTPM
Esophagus	3.1 nTPM
Skeletal muscle	1.9 nTPM
Breast	1.5 nTPM
Bone marrow	1.2 nTPM
Lung	0.8 nTPM
Testis	0.6 nTPM
Ovary	0.5 nTPM
Adipose tissue	0.4 nTPM
Prostate	0.0 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	11.7 nTPM
Rectum	24.7 nTPM
Colon	6.5 nTPM
Small intestine	3.7 nTPM

Plasma cells	1.2 nTPM
Adipose tissue	2.7 nTPM
Bone marrow	1.7 nTPM
Stomach	1.4 nTPM
Spleen	0.3 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	5.7 nTPM
Bronchus	10.0 nTPM
Lung	1.5 nTPM

Smooth muscle cells	21.7 nTPM
Heart muscle	36.7 nTPM
Bronchus	33.1 nTPM
Endometrium	29.5 nTPM
Prostate	26.3 nTPM
Ovary	25.3 nTPM
Skeletal muscle	23.1 nTPM
Breast	19.0 nTPM
Esophagus	17.0 nTPM
Skin	14.3 nTPM
Adipose tissue	9.7 nTPM
Pancreas	4.9 nTPM

T-cells	2.0 nTPM
Liver	10.0 nTPM
Endometrium	3.7 nTPM
Lung	3.0 nTPM
Colon	2.9 nTPM
Bone marrow	2.5 nTPM
Stomach	2.2 nTPM
Breast	2.1 nTPM
Skin	1.9 nTPM
Adipose tissue	1.5 nTPM
Kidney	1.4 nTPM
Spleen	1.4 nTPM
PBMC	0.5 nTPM
Skeletal muscle	0.5 nTPM
Prostate	0.0 nTPM
Ovary	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM

Basal keratinocytes	5.0 nTPM
Skin	5.0 nTPM

Basal prostatic cells	18.9 nTPM
Prostate	18.9 nTPM

Basal respiratory cells	20.8 nTPM
Bronchus	20.8 nTPM

Basal squamous epithelial cells	21.1 nTPM
Esophagus	21.1 nTPM

Undifferentiated cells	23.9 nTPM
Rectum	32.8 nTPM
Colon	22.5 nTPM
Small intestine	16.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC