Single cell type - PLAA - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PLAA
Gene descriptionⁱ Full gene name according to HGNC.	Phospholipase A2 activating protein
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PLAA is part of cluster 10 Non-specific - Unknown function with confidenceⁱ 1
482 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ATXN7L2	Ataxin 7 like 2	0.7036	10
DCUN1D5	Defective in cullin neddylation 1 domain containing 5	0.6715	10
PSMD1	Proteasome 26S subunit, non-ATPase 1	0.6711	10
ANGPTL6	Angiopoietin like 6	0.6334	10
PSMD11	Proteasome 26S subunit, non-ATPase 11	0.6303	10
TBRG1	Transforming growth factor beta regulator 1	0.6192	10
GSTA5	Glutathione S-transferase alpha 5	0.6005	10
SF3B4	Splicing factor 3b subunit 4	0.5861	10
RFC3	Replication factor C subunit 3	0.5827	10
CCT5	Chaperonin containing TCP1 subunit 5	0.5816	10
TSN	Translin	0.5807	10
CCT4	Chaperonin containing TCP1 subunit 4	0.5781	10
POTEM	POTE ankyrin domain family member M	0.5755	10
POLR1C	RNA polymerase I and III subunit C	0.5748	10
FCF1	FCF1 rRNA-processing protein	0.5592	10

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	10.8 nTPM
Adipose tissue	12.8 nTPM
Breast	8.8 nTPM

Alveolar cells type 1	16.0 nTPM
Lung	16.0 nTPM

Alveolar cells type 2	11.2 nTPM
Lung	11.2 nTPM

Astrocytes	18.3 nTPM
Brain	18.3 nTPM

B-cells	18.8 nTPM
Stomach	39.5 nTPM
Spleen	32.2 nTPM
Bone marrow	31.9 nTPM
Lymph node	23.8 nTPM
Colon	14.4 nTPM
Liver	13.8 nTPM
PBMC	12.9 nTPM
Kidney	9.5 nTPM
Adipose tissue	7.5 nTPM
Breast	2.6 nTPM

Dendritic cells	14.9 nTPM
Adipose tissue	19.7 nTPM
Breast	13.1 nTPM
PBMC	12.0 nTPM

Endothelial cells	17.1 nTPM
Lung	40.6 nTPM
Pancreas	34.7 nTPM
Heart muscle	20.3 nTPM
Eye	17.0 nTPM
Placenta	16.5 nTPM
Ovary	16.4 nTPM
Esophagus	16.0 nTPM
Skeletal muscle	15.0 nTPM
Endometrium	14.3 nTPM
Prostate	13.5 nTPM
Skin	9.9 nTPM
Testis	8.9 nTPM
Breast	8.8 nTPM
Liver	7.3 nTPM

Fibroblasts	11.5 nTPM
Skeletal muscle	13.8 nTPM
Ovary	13.8 nTPM
Esophagus	13.8 nTPM
Stomach	13.4 nTPM
Prostate	13.1 nTPM
Lung	12.3 nTPM
Adipose tissue	10.7 nTPM
Heart muscle	10.5 nTPM
Placenta	10.5 nTPM
Breast	7.9 nTPM
Skin	7.1 nTPM

Intestinal goblet cells	8.6 nTPM
Rectum	11.2 nTPM
Colon	8.5 nTPM
Small intestine	6.1 nTPM

Macrophages	17.5 nTPM
Stomach	41.0 nTPM
Spleen	31.1 nTPM
Esophagus	23.6 nTPM
Endometrium	20.1 nTPM
Adipose tissue	19.6 nTPM
Lung	19.4 nTPM
Ovary	18.9 nTPM
Testis	15.7 nTPM
Skeletal muscle	15.7 nTPM
Pancreas	15.3 nTPM
Bone marrow	13.8 nTPM
Breast	10.5 nTPM
Prostate	10.3 nTPM
Kidney	7.6 nTPM
PBMC	0.0 nTPM

Paneth cells	8.7 nTPM
Colon	16.5 nTPM
Rectum	9.7 nTPM
Small intestine	0.0 nTPM

Plasma cells	23.1 nTPM
Spleen	31.2 nTPM
Bone marrow	24.7 nTPM
Stomach	24.0 nTPM
Esophagus	18.4 nTPM
Adipose tissue	17.4 nTPM

Respiratory ciliated cells	12.7 nTPM
Lung	13.1 nTPM
Bronchus	12.2 nTPM

Smooth muscle cells	34.1 nTPM
Bronchus	217.1 nTPM
Heart muscle	22.3 nTPM
Pancreas	22.0 nTPM
Prostate	20.0 nTPM
Ovary	18.0 nTPM
Esophagus	15.5 nTPM
Skeletal muscle	15.4 nTPM
Endometrium	13.8 nTPM
Skin	12.2 nTPM
Adipose tissue	10.8 nTPM
Breast	8.3 nTPM

T-cells	18.3 nTPM
Stomach	43.7 nTPM
Spleen	34.2 nTPM
Lymph node	25.8 nTPM
Bone marrow	24.4 nTPM
Colon	19.5 nTPM
Ovary	17.8 nTPM
Liver	17.1 nTPM
Adipose tissue	17.0 nTPM
Breast	15.9 nTPM
Endometrium	15.1 nTPM
PBMC	14.2 nTPM
Esophagus	13.1 nTPM
Kidney	12.3 nTPM
Lung	12.2 nTPM
Skeletal muscle	10.2 nTPM
Prostate	9.5 nTPM
Skin	8.8 nTPM

Basal keratinocytes	11.0 nTPM
Skin	11.0 nTPM

Basal prostatic cells	11.3 nTPM
Prostate	11.3 nTPM

Basal respiratory cells	14.6 nTPM
Bronchus	14.6 nTPM

Cholangiocytes	5.7 nTPM
Liver	5.7 nTPM

Undifferentiated cells	12.6 nTPM
Small intestine	13.8 nTPM
Rectum	12.4 nTPM
Colon	11.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC