Single cell type - TMEM63B - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TMEM63B
Gene descriptionⁱ Full gene name according to HGNC.	Transmembrane protein 63B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected in immune cells
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Not detected
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (OE19)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TMEM63B is part of cluster 34 Spermatids - Unknown function with confidenceⁱ 1
366 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MAPK3	Mitogen-activated protein kinase 3	0.5017	53
HK2	Hexokinase 2	0.4966	53
DUXA	Double homeobox A	0.4946	34
TAS2R1	Taste 2 receptor member 1	0.4857	34
PRSS51	Serine protease 51	0.4843	34
NPLOC4	NPL4 homolog, ubiquitin recognition factor	0.4766	29
ACP1	Acid phosphatase 1	0.4743	34
ITIH4	Inter-alpha-trypsin inhibitor heavy chain 4	0.4723	15
KCTD11	Potassium channel tetramerization domain containing 11	0.4721	26
GSKIP	GSK3B interacting protein	0.4628	34
ZNF513	Zinc finger protein 513	0.4569	34
COLCA2	Colorectal cancer associated 2	0.4542	34
ATAD1	ATPase family AAA domain containing 1	0.4460	34
MKRN2	Makorin ring finger protein 2	0.4454	34
ANKRD9	Ankyrin repeat domain 9	0.4431	53

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	7.2 nTPM
Adipose tissue	8.7 nTPM
Breast	5.7 nTPM

Alveolar cells type 1	16.0 nTPM
Lung	16.0 nTPM

Alveolar cells type 2	19.7 nTPM
Lung	19.7 nTPM

Astrocytes	17.6 nTPM
Brain	17.6 nTPM

B-cells	3.3 nTPM
Liver	6.0 nTPM
Spleen	4.5 nTPM
Bone marrow	4.1 nTPM
Breast	4.0 nTPM
Stomach	3.7 nTPM
Colon	3.2 nTPM
PBMC	2.8 nTPM
Adipose tissue	2.5 nTPM
Lymph node	2.2 nTPM
Kidney	0.0 nTPM

Dendritic cells	4.2 nTPM
Breast	7.6 nTPM
Adipose tissue	5.1 nTPM
PBMC	0.0 nTPM

Endothelial cells	6.9 nTPM
Ovary	16.3 nTPM
Eye	11.3 nTPM
Prostate	9.2 nTPM
Pancreas	7.7 nTPM
Skin	7.6 nTPM
Testis	7.4 nTPM
Placenta	7.3 nTPM
Breast	6.5 nTPM
Endometrium	6.4 nTPM
Skeletal muscle	6.3 nTPM
Esophagus	5.7 nTPM
Liver	3.7 nTPM
Heart muscle	1.6 nTPM
Lung	0.0 nTPM

Fibroblasts	11.0 nTPM
Prostate	32.3 nTPM
Placenta	15.0 nTPM
Stomach	13.4 nTPM
Skin	10.2 nTPM
Skeletal muscle	10.0 nTPM
Adipose tissue	9.4 nTPM
Esophagus	8.7 nTPM
Ovary	7.6 nTPM
Lung	6.7 nTPM
Breast	6.1 nTPM
Heart muscle	1.4 nTPM

Intestinal goblet cells	32.4 nTPM
Rectum	35.9 nTPM
Small intestine	34.8 nTPM
Colon	26.4 nTPM

Macrophages	9.1 nTPM
Pancreas	17.8 nTPM
Esophagus	15.8 nTPM
Ovary	14.7 nTPM
Spleen	12.5 nTPM
Stomach	11.7 nTPM
Adipose tissue	10.2 nTPM
Endometrium	9.6 nTPM
Skeletal muscle	9.5 nTPM
Prostate	8.1 nTPM
Kidney	7.6 nTPM
Breast	7.0 nTPM
Testis	6.4 nTPM
Bone marrow	3.7 nTPM
Lung	2.4 nTPM
PBMC	0.0 nTPM

Paneth cells	45.7 nTPM
Colon	62.6 nTPM
Rectum	44.6 nTPM
Small intestine	30.0 nTPM

Plasma cells	6.4 nTPM
Stomach	11.0 nTPM
Spleen	8.5 nTPM
Esophagus	6.1 nTPM
Adipose tissue	4.5 nTPM
Bone marrow	1.7 nTPM

Respiratory ciliated cells	15.7 nTPM
Bronchus	31.5 nTPM
Lung	0.0 nTPM

Smooth muscle cells	12.0 nTPM
Bronchus	46.1 nTPM
Prostate	14.4 nTPM
Skeletal muscle	12.0 nTPM
Adipose tissue	11.4 nTPM
Pancreas	11.0 nTPM
Endometrium	10.1 nTPM
Ovary	8.8 nTPM
Skin	8.0 nTPM
Breast	6.7 nTPM
Esophagus	3.1 nTPM
Heart muscle	0.6 nTPM

T-cells	5.5 nTPM
Skin	9.2 nTPM
Endometrium	7.9 nTPM
Kidney	7.5 nTPM
Stomach	7.5 nTPM
Bone marrow	7.4 nTPM
Spleen	6.9 nTPM
Esophagus	6.6 nTPM
Liver	6.1 nTPM
Breast	5.7 nTPM
Colon	4.7 nTPM
Lymph node	4.7 nTPM
Lung	4.5 nTPM
PBMC	4.4 nTPM
Skeletal muscle	4.2 nTPM
Adipose tissue	4.2 nTPM
Ovary	2.2 nTPM
Prostate	0.0 nTPM

Basal keratinocytes	13.6 nTPM
Skin	13.6 nTPM

Basal prostatic cells	14.9 nTPM
Prostate	14.9 nTPM

Basal respiratory cells	41.3 nTPM
Bronchus	41.3 nTPM

Basal squamous epithelial cells	21.1 nTPM
Esophagus	21.1 nTPM

Undifferentiated cells	24.3 nTPM
Rectum	30.1 nTPM
Colon	28.8 nTPM
Small intestine	13.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC