Single cell type - ENTPD1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ENTPD1
Gene descriptionⁱ Full gene name according to HGNC.	Ectonucleoside triphosphate diphosphohydrolase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	CD markers Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Macrophages - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Microglial cells, Langerhans cells, monocytes, Kupffer cells, Plasma cells, Astrocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (eosinophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Group enriched (HDLM-2, Karpas-707)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Microglial cells, Langerhans cells, monocytes, Kupffer cells, Plasma cells, Astrocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ENTPD1 is part of cluster 41 Macrophages - Immune response with confidenceⁱ 1
307 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
AP1S2	Adaptor related protein complex 1 subunit sigma 2	0.6156	19
CD1E	CD1e molecule	0.5707	41
CLEC4A	C-type lectin domain family 4 member A	0.5564	19
CD1B	CD1b molecule	0.5547	41
HLA-DQB2	Major histocompatibility complex, class II, DQ beta 2	0.5444	41
ASCL4	Achaete-scute family bHLH transcription factor 4	0.5442	41
FCER1A	Fc fragment of IgE receptor Ia	0.5401	41
CD1A	CD1a molecule	0.5357	41
CLEC10A	C-type lectin domain containing 10A	0.5287	41
CCL13	C-C motif chemokine ligand 13	0.5235	41
HLA-DRB5	Major histocompatibility complex, class II, DR beta 5	0.5235	41
CD93	CD93 molecule	0.5223	14
C1orf54	Chromosome 1 open reading frame 54	0.5207	41
SCARF1	Scavenger receptor class F member 1	0.5144	14
CD1C	CD1c molecule	0.5143	41

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	19.6 nTPM
Adipose tissue	24.0 nTPM
Breast	15.1 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	1.1 nTPM
Lung	1.1 nTPM

B-cells	40.9 nTPM
Liver	77.0 nTPM
Colon	67.1 nTPM
Stomach	53.6 nTPM
PBMC	45.7 nTPM
Spleen	39.1 nTPM
Adipose tissue	33.6 nTPM
Lymph node	33.6 nTPM
Bone marrow	32.7 nTPM
Breast	17.3 nTPM
Kidney	9.5 nTPM

Basal keratinocytes	8.9 nTPM
Skin	8.9 nTPM

Dendritic cells	3.7 nTPM
Adipose tissue	6.5 nTPM
PBMC	4.0 nTPM
Breast	0.7 nTPM

Endothelial cells	60.6 nTPM
Endometrium	127.7 nTPM
Testis	123.6 nTPM
Ovary	87.7 nTPM
Placenta	87.5 nTPM
Esophagus	60.5 nTPM
Prostate	56.1 nTPM
Pancreas	50.2 nTPM
Eye	47.7 nTPM
Skin	47.6 nTPM
Heart muscle	42.0 nTPM
Liver	35.7 nTPM
Breast	34.0 nTPM
Skeletal muscle	33.0 nTPM
Lung	15.6 nTPM

Fibroblasts	15.7 nTPM
Skin	37.9 nTPM
Breast	36.2 nTPM
Esophagus	35.0 nTPM
Stomach	22.3 nTPM
Heart muscle	15.4 nTPM
Prostate	9.9 nTPM
Lung	8.9 nTPM
Skeletal muscle	3.7 nTPM
Placenta	1.5 nTPM
Adipose tissue	0.9 nTPM
Ovary	0.7 nTPM

Intestinal goblet cells	0.1 nTPM
Small intestine	0.4 nTPM
Colon	0.0 nTPM
Rectum	0.0 nTPM

Macrophages	62.1 nTPM
Prostate	157.0 nTPM
Testis	110.4 nTPM
Adipose tissue	97.1 nTPM
Skeletal muscle	81.8 nTPM
Spleen	60.2 nTPM
Stomach	58.6 nTPM
Kidney	54.4 nTPM
Breast	53.0 nTPM
Ovary	50.2 nTPM
Endometrium	48.5 nTPM
Bone marrow	47.5 nTPM
Esophagus	45.6 nTPM
Lung	32.8 nTPM
Pancreas	20.4 nTPM
PBMC	13.6 nTPM

Paneth cells	1.2 nTPM
Colon	3.3 nTPM
Rectum	0.2 nTPM
Small intestine	0.0 nTPM

Plasma cells	80.1 nTPM
Bone marrow	131.8 nTPM
Spleen	99.5 nTPM
Stomach	79.3 nTPM
Esophagus	67.8 nTPM
Adipose tissue	21.9 nTPM

Respiratory ciliated cells	0.8 nTPM
Lung	1.5 nTPM
Bronchus	0.1 nTPM

Smooth muscle cells	22.7 nTPM
Heart muscle	50.0 nTPM
Skin	42.2 nTPM
Esophagus	38.8 nTPM
Prostate	36.0 nTPM
Breast	30.2 nTPM
Endometrium	18.8 nTPM
Skeletal muscle	14.0 nTPM
Adipose tissue	10.0 nTPM
Ovary	8.9 nTPM
Pancreas	0.9 nTPM
Bronchus	0.0 nTPM

T-cells	26.9 nTPM
Colon	233.3 nTPM
Stomach	100.2 nTPM
Prostate	33.1 nTPM
Skin	16.1 nTPM
Esophagus	13.1 nTPM
Liver	7.7 nTPM
Adipose tissue	7.6 nTPM
Lymph node	7.3 nTPM
Breast	7.1 nTPM
Endometrium	6.7 nTPM
Lung	6.1 nTPM
Spleen	5.0 nTPM
Skeletal muscle	4.7 nTPM
Bone marrow	3.8 nTPM
Ovary	2.2 nTPM
Kidney	2.0 nTPM
PBMC	2.0 nTPM

Astrocytes	74.1 nTPM
Brain	74.1 nTPM

Collecting duct cells	1.8 nTPM
Kidney	1.8 nTPM

Cone photoreceptor cells	2.1 nTPM
Eye	2.1 nTPM

Cytotrophoblasts	0.6 nTPM
Placenta	0.6 nTPM

Undifferentiated cells	1.0 nTPM
Colon	2.5 nTPM
Rectum	0.4 nTPM
Small intestine	0.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC