Single cell type - STAT4 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	STAT4
Gene descriptionⁱ Full gene name according to HGNC.	Signal transducer and activator of transcription 4
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Human disease related genes Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription regulation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Early spermatids, dendritic cells, T-cells, NK-cells, Excitatory neurons, Plasma cells, Late spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (Karpas-707, U-266/70, U-266/84)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Early spermatids, dendritic cells, T-cells, NK-cells, Excitatory neurons, Plasma cells, Late spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

STAT4 is part of cluster 24 Non-specific - Transcription regulation with confidenceⁱ 1
415 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PARP8	Poly(ADP-ribose) polymerase family member 8	0.7428	24
RNF125	Ring finger protein 125	0.7257	24
CNOT6L	CCR4-NOT transcription complex subunit 6 like	0.7153	24
SYTL3	Synaptotagmin like 3	0.7035	24
IPCEF1	Interaction protein for cytohesin exchange factors 1	0.6979	24
SLA	Src like adaptor	0.6851	24
RGPD2	RANBP2 like and GRIP domain containing 2	0.6777	24
TAFA1	TAFA chemokine like family member 1	0.6576	24
ADGRE5	Adhesion G protein-coupled receptor E5	0.6563	24
ZNF831	Zinc finger protein 831	0.6538	24
PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1	0.6498	24
PLAAT2	Phospholipase A and acyltransferase 2	0.6474	24
H2AC15	H2A clustered histone 15	0.6438	24
HIPK1	Homeodomain interacting protein kinase 1	0.6419	24
ZBED4	Zinc finger BED-type containing 4	0.6416	24

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	2.9 nTPM
Adipose tissue	3.0 nTPM
Breast	2.7 nTPM

Alveolar cells type 1	3.2 nTPM
Lung	3.2 nTPM

Alveolar cells type 2	4.2 nTPM
Lung	4.2 nTPM

Astrocytes	2.6 nTPM
Brain	2.6 nTPM

B-cells	14.5 nTPM
Adipose tissue	42.6 nTPM
Stomach	30.9 nTPM
Colon	22.3 nTPM
Spleen	20.4 nTPM
Lymph node	11.1 nTPM
Breast	10.7 nTPM
PBMC	2.8 nTPM
Liver	2.5 nTPM
Bone marrow	1.7 nTPM
Kidney	0.0 nTPM

Dendritic cells	139.0 nTPM
Adipose tissue	347.5 nTPM
Breast	65.6 nTPM
PBMC	4.0 nTPM

Endothelial cells	1.2 nTPM
Skin	5.1 nTPM
Heart muscle	4.0 nTPM
Skeletal muscle	2.2 nTPM
Breast	1.9 nTPM
Esophagus	1.0 nTPM
Liver	0.9 nTPM
Endometrium	0.9 nTPM
Prostate	0.7 nTPM
Placenta	0.6 nTPM
Ovary	0.1 nTPM
Eye	0.0 nTPM
Lung	0.0 nTPM
Testis	0.0 nTPM
Pancreas	0.0 nTPM

Fibroblasts	2.9 nTPM
Heart muscle	9.2 nTPM
Esophagus	6.9 nTPM
Stomach	6.0 nTPM
Breast	2.6 nTPM
Lung	2.2 nTPM
Skin	2.1 nTPM
Prostate	0.7 nTPM
Placenta	0.5 nTPM
Skeletal muscle	0.5 nTPM
Ovary	0.5 nTPM
Adipose tissue	0.5 nTPM

Intestinal goblet cells	0.3 nTPM
Colon	0.7 nTPM
Rectum	0.2 nTPM
Small intestine	0.0 nTPM

Macrophages	14.4 nTPM
Adipose tissue	55.4 nTPM
Prostate	47.0 nTPM
Stomach	29.4 nTPM
Endometrium	16.1 nTPM
Breast	14.7 nTPM
Spleen	12.5 nTPM
Skeletal muscle	9.9 nTPM
Pancreas	7.7 nTPM
Lung	7.4 nTPM
Bone marrow	6.2 nTPM
Esophagus	3.1 nTPM
Ovary	3.0 nTPM
Testis	1.7 nTPM
Kidney	1.5 nTPM
PBMC	0.0 nTPM

Paneth cells	0.3 nTPM
Rectum	1.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	83.8 nTPM
Adipose tissue	365.7 nTPM
Stomach	30.3 nTPM
Spleen	8.8 nTPM
Bone marrow	8.2 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	2.4 nTPM
Bronchus	4.8 nTPM
Lung	0.0 nTPM

Smooth muscle cells	3.7 nTPM
Heart muscle	11.7 nTPM
Adipose tissue	10.2 nTPM
Skeletal muscle	7.2 nTPM
Breast	4.8 nTPM
Skin	3.2 nTPM
Prostate	1.5 nTPM
Endometrium	1.5 nTPM
Ovary	0.9 nTPM
Pancreas	0.2 nTPM
Bronchus	0.0 nTPM
Esophagus	0.0 nTPM

T-cells	137.4 nTPM
Adipose tissue	410.2 nTPM
Stomach	241.9 nTPM
Spleen	216.3 nTPM
Prostate	203.6 nTPM
Colon	140.7 nTPM
Lymph node	131.6 nTPM
Endometrium	131.3 nTPM
Bone marrow	125.9 nTPM
Skeletal muscle	118.6 nTPM
Ovary	100.1 nTPM
Skin	93.4 nTPM
Kidney	90.3 nTPM
Liver	87.4 nTPM
Breast	87.2 nTPM
PBMC	57.6 nTPM
Lung	53.2 nTPM
Esophagus	45.9 nTPM

Basal keratinocytes	1.3 nTPM
Skin	1.3 nTPM

Cholangiocytes	4.3 nTPM
Liver	4.3 nTPM

Collecting duct cells	1.8 nTPM
Kidney	1.8 nTPM

Cone photoreceptor cells	8.4 nTPM
Eye	8.4 nTPM

Undifferentiated cells	0.3 nTPM
Colon	0.7 nTPM
Rectum	0.3 nTPM
Small intestine	0.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC