Single cell type - ALDH18A1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ALDH18A1
Gene descriptionⁱ Full gene name according to HGNC.	Aldehyde dehydrogenase 18 family member A1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Granulosa cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Granulosa cells, Distal enterocytes, Proximal enterocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Granulosa cells, Distal enterocytes, Proximal enterocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ALDH18A1 is part of cluster 40 Granulosa cells - Unknown function with confidenceⁱ 1
316 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PRR15	Proline rich 15	0.8102	53
LAMA1	Laminin subunit alpha 1	0.7755	53
IHH	Indian hedgehog signaling molecule	0.7667	40
CES3	Carboxylesterase 3	0.7272	53
GOLPH3L	Golgi phosphoprotein 3 like	0.6663	40
MARVELD1	MARVEL domain containing 1	0.6643	40
BMP3	Bone morphogenetic protein 3	0.6571	40
CASP6	Caspase 6	0.6551	40
MAGED2	MAGE family member D2	0.6528	40
LRP5	LDL receptor related protein 5	0.6508	40
AMH	Anti-Mullerian hormone	0.6506	40
GREM1	Gremlin 1, DAN family BMP antagonist	0.6487	40
ELK1	ETS transcription factor ELK1	0.6361	40
GPR1	G protein-coupled receptor 1	0.6360	40
CRYGD	Crystallin gamma D	0.6347	40

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	4.6 nTPM
Breast	4.9 nTPM
Adipose tissue	4.3 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	9.2 nTPM
Lung	9.2 nTPM

Astrocytes	7.2 nTPM
Brain	7.2 nTPM

B-cells	12.6 nTPM
Liver	31.8 nTPM
Breast	16.0 nTPM
Spleen	15.6 nTPM
Bone marrow	13.9 nTPM
PBMC	11.5 nTPM
Stomach	10.9 nTPM
Colon	9.6 nTPM
Lymph node	7.3 nTPM
Adipose tissue	5.0 nTPM
Kidney	4.8 nTPM

Dendritic cells	6.7 nTPM
PBMC	8.0 nTPM
Breast	7.2 nTPM
Adipose tissue	4.9 nTPM

Endothelial cells	8.0 nTPM
Endometrium	18.0 nTPM
Placenta	15.3 nTPM
Prostate	10.4 nTPM
Heart muscle	8.4 nTPM
Ovary	8.4 nTPM
Esophagus	7.7 nTPM
Breast	7.6 nTPM
Lung	6.2 nTPM
Skin	6.0 nTPM
Testis	5.9 nTPM
Eye	4.8 nTPM
Skeletal muscle	4.8 nTPM
Liver	4.6 nTPM
Pancreas	3.9 nTPM

Fibroblasts	16.2 nTPM
Placenta	37.5 nTPM
Ovary	26.8 nTPM
Lung	19.0 nTPM
Skeletal muscle	15.3 nTPM
Breast	14.0 nTPM
Esophagus	12.5 nTPM
Heart muscle	11.6 nTPM
Skin	11.3 nTPM
Adipose tissue	11.0 nTPM
Prostate	10.3 nTPM
Stomach	8.9 nTPM

Intestinal goblet cells	41.3 nTPM
Colon	44.3 nTPM
Rectum	41.5 nTPM
Small intestine	38.0 nTPM

Macrophages	3.5 nTPM
Prostate	8.1 nTPM
Endometrium	6.5 nTPM
Esophagus	6.3 nTPM
Breast	4.9 nTPM
Kidney	4.6 nTPM
Ovary	3.8 nTPM
Bone marrow	3.7 nTPM
Spleen	3.1 nTPM
Lung	2.9 nTPM
Pancreas	2.5 nTPM
Skeletal muscle	2.3 nTPM
Adipose tissue	2.3 nTPM
Testis	1.2 nTPM
PBMC	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	56.4 nTPM
Colon	62.6 nTPM
Small intestine	60.1 nTPM
Rectum	46.5 nTPM

Plasma cells	30.1 nTPM
Stomach	65.5 nTPM
Spleen	38.1 nTPM
Bone marrow	33.0 nTPM
Adipose tissue	7.8 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	15.2 nTPM
Lung	17.5 nTPM
Bronchus	13.0 nTPM

Smooth muscle cells	10.1 nTPM
Pancreas	27.6 nTPM
Ovary	17.2 nTPM
Endometrium	15.5 nTPM
Heart muscle	9.8 nTPM
Esophagus	9.3 nTPM
Breast	6.5 nTPM
Prostate	6.2 nTPM
Bronchus	5.7 nTPM
Adipose tissue	4.8 nTPM
Skeletal muscle	4.4 nTPM
Skin	4.2 nTPM

T-cells	9.0 nTPM
Stomach	13.9 nTPM
Esophagus	13.1 nTPM
Bone marrow	13.0 nTPM
Kidney	10.9 nTPM
Colon	10.5 nTPM
Spleen	10.2 nTPM
Prostate	9.5 nTPM
PBMC	9.4 nTPM
Liver	9.1 nTPM
Endometrium	9.1 nTPM
Breast	8.8 nTPM
Lymph node	8.7 nTPM
Skeletal muscle	6.2 nTPM
Skin	6.0 nTPM
Adipose tissue	5.6 nTPM
Lung	4.5 nTPM
Ovary	4.5 nTPM

Basal keratinocytes	11.2 nTPM
Skin	11.2 nTPM

Basal prostatic cells	8.3 nTPM
Prostate	8.3 nTPM

Basal squamous epithelial cells	14.2 nTPM
Esophagus	14.2 nTPM

Collecting duct cells	20.2 nTPM
Kidney	20.2 nTPM

Undifferentiated cells	38.7 nTPM
Small intestine	52.7 nTPM
Rectum	32.2 nTPM
Colon	31.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC