Single cell type - ETNK1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ETNK1
Gene descriptionⁱ Full gene name according to HGNC.	Ethanolamine kinase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Enzymes Human disease related genes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Flagellum & Golgi organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Early spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Early spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ETNK1 is part of cluster 23 Spermatids - Flagellum & Golgi organization with confidenceⁱ 0.79
311 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TJP3	Tight junction protein 3	0.5413	53
HIGD1C	HIG1 hypoxia inducible domain family member 1C	0.5356	23
GOLGA6B	Golgin A6 family member B	0.5125	23
NSUN3	NOP2/Sun RNA methyltransferase 3	0.5116	29
GSTCD	Glutathione S-transferase C-terminal domain containing	0.4969	29
SREK1IP1	SREK1 interacting protein 1	0.4896	53
HERC4	HECT and RLD domain containing E3 ubiquitin protein ligase 4	0.4852	53
RFPL1	Ret finger protein like 1	0.4812	29
INSL6	Insulin like 6	0.4686	29
DYM	Dymeclin	0.4642	23
WRN	WRN RecQ like helicase	0.4598	29
ZNF165	Zinc finger protein 165	0.4582	53
SLC30A10	Solute carrier family 30 member 10	0.4486	53
BPIFC	BPI fold containing family C	0.4471	23
ATP6V0D1	ATPase H+ transporting V0 subunit d1	0.4462	4

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	33.6 nTPM
Adipose tissue	39.5 nTPM
Breast	27.8 nTPM

Alveolar cells type 1	48.1 nTPM
Lung	48.1 nTPM

Alveolar cells type 2	32.2 nTPM
Lung	32.2 nTPM

Astrocytes	48.0 nTPM
Brain	48.0 nTPM

B-cells	55.9 nTPM
Spleen	81.6 nTPM
Adipose tissue	72.7 nTPM
Stomach	66.8 nTPM
Bone marrow	61.3 nTPM
Colon	54.3 nTPM
Kidney	52.4 nTPM
Lymph node	49.5 nTPM
Breast	45.4 nTPM
Liver	39.5 nTPM
PBMC	35.7 nTPM

Dendritic cells	57.6 nTPM
Adipose tissue	77.2 nTPM
PBMC	47.8 nTPM
Breast	47.7 nTPM

Endothelial cells	34.8 nTPM
Prostate	67.4 nTPM
Endometrium	53.1 nTPM
Skin	49.0 nTPM
Heart muscle	37.2 nTPM
Eye	31.6 nTPM
Breast	31.6 nTPM
Pancreas	30.9 nTPM
Ovary	29.5 nTPM
Skeletal muscle	29.1 nTPM
Testis	28.5 nTPM
Liver	28.4 nTPM
Placenta	26.1 nTPM
Esophagus	25.7 nTPM
Lung	18.7 nTPM

Enteroendocrine cells	108.3 nTPM
Colon	124.3 nTPM
Rectum	92.2 nTPM

Fibroblasts	38.2 nTPM
Prostate	126.8 nTPM
Skin	57.7 nTPM
Adipose tissue	48.1 nTPM
Breast	32.5 nTPM
Ovary	28.2 nTPM
Stomach	26.7 nTPM
Esophagus	25.4 nTPM
Skeletal muscle	25.3 nTPM
Placenta	18.8 nTPM
Heart muscle	17.1 nTPM
Lung	13.4 nTPM

Intestinal goblet cells	60.7 nTPM
Colon	77.2 nTPM
Rectum	53.0 nTPM
Small intestine	51.7 nTPM

Macrophages	57.0 nTPM
Prostate	97.4 nTPM
Ovary	76.7 nTPM
Bone marrow	73.7 nTPM
Adipose tissue	72.4 nTPM
Spleen	70.5 nTPM
Kidney	62.0 nTPM
Stomach	61.5 nTPM
Esophagus	58.3 nTPM
Breast	49.9 nTPM
Endometrium	49.5 nTPM
Testis	48.7 nTPM
Pancreas	48.5 nTPM
Skeletal muscle	38.9 nTPM
Lung	33.3 nTPM
PBMC	13.6 nTPM

Paneth cells	62.9 nTPM
Colon	88.9 nTPM
Rectum	51.0 nTPM
Small intestine	48.8 nTPM

Plasma cells	63.7 nTPM
Stomach	76.5 nTPM
Adipose tissue	67.1 nTPM
Spleen	63.0 nTPM
Bone marrow	62.6 nTPM
Esophagus	49.4 nTPM

Respiratory ciliated cells	81.6 nTPM
Bronchus	84.5 nTPM
Lung	78.7 nTPM

Smooth muscle cells	38.9 nTPM
Prostate	73.8 nTPM
Skin	54.0 nTPM
Adipose tissue	50.4 nTPM
Endometrium	46.7 nTPM
Ovary	42.3 nTPM
Skeletal muscle	33.5 nTPM
Breast	29.6 nTPM
Heart muscle	27.8 nTPM
Bronchus	25.3 nTPM
Pancreas	23.3 nTPM
Esophagus	21.7 nTPM

Basal keratinocytes	144.3 nTPM
Skin	144.3 nTPM

Basal prostatic cells	75.7 nTPM
Prostate	75.7 nTPM

Basal respiratory cells	34.7 nTPM
Bronchus	34.7 nTPM

Basal squamous epithelial cells	64.9 nTPM
Esophagus	64.9 nTPM

T-cells	49.0 nTPM
Skin	69.1 nTPM
Adipose tissue	67.5 nTPM
Esophagus	65.5 nTPM
Spleen	64.2 nTPM
Bone marrow	59.3 nTPM
Stomach	58.9 nTPM
Colon	52.2 nTPM
Endometrium	50.1 nTPM
Ovary	44.5 nTPM
Liver	42.8 nTPM
Prostate	42.6 nTPM
Lymph node	42.4 nTPM
Breast	41.7 nTPM
Kidney	39.7 nTPM
Skeletal muscle	36.3 nTPM
PBMC	28.9 nTPM
Lung	27.4 nTPM

Undifferentiated cells	47.8 nTPM
Colon	66.8 nTPM
Rectum	41.2 nTPM
Small intestine	35.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC