Single cell type - TCHP - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TCHP
Gene descriptionⁱ Full gene name according to HGNC.	Trichoplein keratin filament binding
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TCHP is part of cluster 52 Non-specific - Transcription with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
BAZ1B	Bromodomain adjacent to zinc finger domain 1B	0.4532	10
SLF2	SMC5-SMC6 complex localization factor 2	0.4461	52
CEP126	Centrosomal protein 126	0.4392	49
TTLL3	Tubulin tyrosine ligase like 3	0.4361	52
AC118553.2	Novel protein	0.4304	52
FBXO6	F-box protein 6	0.4230	63
C21orf58	Chromosome 21 open reading frame 58	0.4176	49
ETAA1	ETAA1 activator of ATR kinase	0.4137	7
POU5F2	POU domain class 5, transcription factor 2	0.4011	66
IWS1	Interacts with SUPT6H, CTD assembly factor 1	0.4004	10
ZNF70	Zinc finger protein 70	0.3993	52
TUBGCP2	Tubulin gamma complex associated protein 2	0.3964	49
L3MBTL2	L3MBTL histone methyl-lysine binding protein 2	0.3919	25
RNF20	Ring finger protein 20	0.3912	66
ZBTB37	Zinc finger and BTB domain containing 37	0.3890	46

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	11.7 nTPM
Breast	13.3 nTPM
Adipose tissue	10.1 nTPM

Alveolar cells type 1	19.2 nTPM
Lung	19.2 nTPM

Alveolar cells type 2	21.4 nTPM
Lung	21.4 nTPM

Astrocytes	18.9 nTPM
Brain	18.9 nTPM

B-cells	10.4 nTPM
Liver	13.8 nTPM
Bone marrow	13.1 nTPM
PBMC	12.9 nTPM
Breast	12.1 nTPM
Spleen	11.4 nTPM
Adipose tissue	10.5 nTPM
Colon	9.6 nTPM
Lymph node	8.7 nTPM
Stomach	6.8 nTPM
Kidney	4.8 nTPM

Dendritic cells	14.3 nTPM
Adipose tissue	20.6 nTPM
Breast	18.2 nTPM
PBMC	4.0 nTPM

Endothelial cells	15.2 nTPM
Lung	40.6 nTPM
Ovary	20.9 nTPM
Heart muscle	17.3 nTPM
Endometrium	15.8 nTPM
Pancreas	15.5 nTPM
Testis	14.5 nTPM
Breast	14.5 nTPM
Placenta	13.1 nTPM
Liver	12.8 nTPM
Eye	12.2 nTPM
Skeletal muscle	12.2 nTPM
Esophagus	8.1 nTPM
Prostate	7.8 nTPM
Skin	7.7 nTPM

Fibroblasts	11.4 nTPM
Heart muscle	20.6 nTPM
Ovary	18.8 nTPM
Skeletal muscle	15.9 nTPM
Stomach	11.9 nTPM
Esophagus	10.5 nTPM
Adipose tissue	9.2 nTPM
Breast	8.9 nTPM
Placenta	8.4 nTPM
Lung	7.8 nTPM
Prostate	7.2 nTPM
Skin	6.7 nTPM

Intestinal goblet cells	10.7 nTPM
Small intestine	13.4 nTPM
Colon	12.9 nTPM
Rectum	5.7 nTPM

Macrophages	11.4 nTPM
Lung	21.6 nTPM
Spleen	19.7 nTPM
Bone marrow	17.5 nTPM
Testis	17.4 nTPM
Skeletal muscle	13.9 nTPM
Breast	12.9 nTPM
Endometrium	12.7 nTPM
Kidney	12.0 nTPM
Ovary	9.9 nTPM
Esophagus	9.4 nTPM
Prostate	9.1 nTPM
Stomach	5.9 nTPM
Adipose tissue	5.8 nTPM
Pancreas	2.5 nTPM
PBMC	0.0 nTPM

Paneth cells	14.4 nTPM
Colon	23.1 nTPM
Small intestine	11.3 nTPM
Rectum	8.8 nTPM

Plasma cells	15.0 nTPM
Bone marrow	24.7 nTPM
Spleen	17.3 nTPM
Adipose tissue	13.0 nTPM
Esophagus	12.3 nTPM
Stomach	7.9 nTPM

Respiratory ciliated cells	33.6 nTPM
Lung	39.4 nTPM
Bronchus	27.8 nTPM

Smooth muscle cells	12.6 nTPM
Esophagus	20.1 nTPM
Ovary	18.6 nTPM
Endometrium	18.0 nTPM
Pancreas	16.9 nTPM
Heart muscle	16.5 nTPM
Prostate	11.2 nTPM
Breast	10.3 nTPM
Adipose tissue	8.3 nTPM
Skeletal muscle	8.2 nTPM
Bronchus	5.6 nTPM
Skin	4.5 nTPM

T-cells	15.9 nTPM
Ovary	26.7 nTPM
Lung	22.8 nTPM
Endometrium	21.1 nTPM
Liver	20.5 nTPM
Skeletal muscle	20.1 nTPM
Bone marrow	19.2 nTPM
Kidney	18.5 nTPM
PBMC	16.4 nTPM
Breast	14.9 nTPM
Esophagus	13.1 nTPM
Colon	12.4 nTPM
Lymph node	11.5 nTPM
Adipose tissue	11.0 nTPM
Spleen	11.0 nTPM
Stomach	11.0 nTPM
Skin	10.5 nTPM
Prostate	9.5 nTPM

Basal keratinocytes	9.8 nTPM
Skin	9.8 nTPM

Basal squamous epithelial cells	8.0 nTPM
Esophagus	8.0 nTPM

Cholangiocytes	17.2 nTPM
Liver	17.2 nTPM

Collecting duct cells	7.3 nTPM
Kidney	7.3 nTPM

Undifferentiated cells	12.2 nTPM
Small intestine	14.6 nTPM
Colon	12.6 nTPM
Rectum	9.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC