Single cell type - G6PC3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	G6PC3
Gene descriptionⁱ Full gene name according to HGNC.	Glucose-6-phosphatase catalytic subunit 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Cytotrophoblasts - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

G6PC3 is part of cluster 47 Cytotrophoblasts - Unknown function with confidenceⁱ 0.82
226 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SLC35B2	Solute carrier family 35 member B2	0.5807	55
SCAMP3	Secretory carrier membrane protein 3	0.5679	55
FADD	Fas associated via death domain	0.5671	47
DPAGT1	Dolichyl-phosphate N-acetylglucosaminephosphotransferase 1	0.5668	55
PUDP	Pseudouridine 5'-phosphatase	0.5598	47
RHBDD3	Rhomboid domain containing 3	0.5441	47
COPS7A	COP9 signalosome subunit 7A	0.5418	47
PTPA	Protein phosphatase 2 phosphatase activator	0.5410	7
TMED1	Transmembrane p24 trafficking protein 1	0.5392	55
VPS25	Vacuolar protein sorting 25 homolog	0.5345	10
ZDHHC24	Zinc finger DHHC-type containing 24	0.5245	4
ALG1	ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase	0.5222	55
PIGO	Phosphatidylinositol glycan anchor biosynthesis class O	0.5113	55
MFSD5	Major facilitator superfamily domain containing 5	0.5111	47
AAR2	AAR2 splicing factor	0.5093	47

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	22.3 nTPM
Adipose tissue	24.8 nTPM
Breast	19.9 nTPM

Alveolar cells type 1	3.2 nTPM
Lung	3.2 nTPM

Alveolar cells type 2	12.9 nTPM
Lung	12.9 nTPM

Astrocytes	5.2 nTPM
Brain	5.2 nTPM

B-cells	10.4 nTPM
Liver	29.7 nTPM
Kidney	14.3 nTPM
Spleen	12.1 nTPM
Stomach	10.5 nTPM
Colon	9.6 nTPM
Breast	8.1 nTPM
Lymph node	7.0 nTPM
Bone marrow	5.7 nTPM
PBMC	4.3 nTPM
Adipose tissue	3.0 nTPM

Dendritic cells	17.1 nTPM
PBMC	35.8 nTPM
Adipose tissue	8.3 nTPM
Breast	7.2 nTPM

Endothelial cells	26.0 nTPM
Placenta	73.3 nTPM
Testis	37.7 nTPM
Esophagus	36.5 nTPM
Ovary	36.3 nTPM
Eye	26.7 nTPM
Breast	26.5 nTPM
Endometrium	25.4 nTPM
Pancreas	19.3 nTPM
Prostate	18.1 nTPM
Liver	15.6 nTPM
Lung	15.6 nTPM
Skin	14.2 nTPM
Skeletal muscle	13.9 nTPM
Heart muscle	4.8 nTPM

Fibroblasts	25.0 nTPM
Placenta	46.1 nTPM
Ovary	39.1 nTPM
Esophagus	35.8 nTPM
Adipose tissue	31.1 nTPM
Stomach	28.2 nTPM
Breast	24.0 nTPM
Skeletal muscle	17.2 nTPM
Lung	16.8 nTPM
Skin	15.6 nTPM
Prostate	15.4 nTPM
Heart muscle	5.8 nTPM

Intestinal goblet cells	14.1 nTPM
Colon	17.2 nTPM
Rectum	13.1 nTPM
Small intestine	12.1 nTPM

Macrophages	20.9 nTPM
Pancreas	43.4 nTPM
Kidney	30.3 nTPM
Esophagus	29.9 nTPM
Bone marrow	25.0 nTPM
Spleen	24.9 nTPM
Stomach	23.5 nTPM
Testis	20.9 nTPM
Ovary	20.5 nTPM
Adipose tissue	20.1 nTPM
Endometrium	18.5 nTPM
Lung	16.4 nTPM
Prostate	15.0 nTPM
Breast	14.9 nTPM
Skeletal muscle	9.9 nTPM
PBMC	0.0 nTPM

Paneth cells	13.6 nTPM
Rectum	19.3 nTPM
Small intestine	15.0 nTPM
Colon	6.5 nTPM

Plasma cells	27.2 nTPM
Bone marrow	51.1 nTPM
Spleen	35.2 nTPM
Stomach	26.7 nTPM
Esophagus	18.4 nTPM
Adipose tissue	4.5 nTPM

Respiratory ciliated cells	24.6 nTPM
Bronchus	31.7 nTPM
Lung	17.5 nTPM

Smooth muscle cells	21.4 nTPM
Pancreas	63.3 nTPM
Bronchus	52.9 nTPM
Esophagus	23.3 nTPM
Endometrium	17.8 nTPM
Ovary	15.1 nTPM
Adipose tissue	14.7 nTPM
Breast	12.4 nTPM
Skeletal muscle	10.5 nTPM
Skin	9.8 nTPM
Prostate	9.7 nTPM
Heart muscle	6.1 nTPM

T-cells	7.0 nTPM
Liver	13.1 nTPM
Bone marrow	11.8 nTPM
Stomach	11.6 nTPM
Spleen	9.8 nTPM
Prostate	9.5 nTPM
Kidney	8.9 nTPM
PBMC	8.3 nTPM
Endometrium	7.6 nTPM
Colon	6.2 nTPM
Skin	6.0 nTPM
Lymph node	5.7 nTPM
Adipose tissue	4.6 nTPM
Lung	4.5 nTPM
Breast	4.5 nTPM
Skeletal muscle	4.4 nTPM
Ovary	2.2 nTPM
Esophagus	0.0 nTPM

Basal keratinocytes	2.5 nTPM
Skin	2.5 nTPM

Basal prostatic cells	17.3 nTPM
Prostate	17.3 nTPM

Basal respiratory cells	31.8 nTPM
Bronchus	31.8 nTPM

Basal squamous epithelial cells	8.0 nTPM
Esophagus	8.0 nTPM

Undifferentiated cells	19.7 nTPM
Small intestine	25.4 nTPM
Rectum	18.6 nTPM
Colon	15.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC