Single cell type - MFSD5 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MFSD5
Gene descriptionⁱ Full gene name according to HGNC.	Major facilitator superfamily domain containing 5
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Cytotrophoblasts - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MFSD5 is part of cluster 47 Cytotrophoblasts - Unknown function with confidenceⁱ 0.98
226 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SHISA5	Shisa family member 5	0.5922	47
SCAMP3	Secretory carrier membrane protein 3	0.5712	55
HEXB	Hexosaminidase subunit beta	0.5687	47
NCSTN	Nicastrin	0.5632	47
APEX2	Apurinic/apyrimidinic endodeoxyribonuclease 2	0.5518	47
MED20	Mediator complex subunit 20	0.5471	47
COMT	Catechol-O-methyltransferase	0.5432	47
MYO7A	Myosin VIIA	0.5347	47
EPN3	Epsin 3	0.5219	47
MUL1	Mitochondrial E3 ubiquitin protein ligase 1	0.5195	47
IL10RB	Interleukin 10 receptor subunit beta	0.5132	18
PEX11B	Peroxisomal biogenesis factor 11 beta	0.5116	47
XKR8	XK related 8	0.5112	47
GBA	Glucosylceramidase beta	0.5112	10
G6PC3	Glucose-6-phosphatase catalytic subunit 3	0.5111	47

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	5.5 nTPM
Breast	6.3 nTPM
Adipose tissue	4.7 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	10.6 nTPM
Lung	10.6 nTPM

Astrocytes	6.2 nTPM
Brain	6.2 nTPM

B-cells	12.1 nTPM
Bone marrow	22.1 nTPM
Spleen	19.7 nTPM
Stomach	19.5 nTPM
PBMC	9.9 nTPM
Kidney	9.5 nTPM
Adipose tissue	9.0 nTPM
Liver	8.8 nTPM
Lymph node	8.8 nTPM
Colon	8.0 nTPM
Breast	5.3 nTPM

Dendritic cells	7.8 nTPM
Adipose tissue	10.0 nTPM
PBMC	8.0 nTPM
Breast	5.4 nTPM

Endothelial cells	10.8 nTPM
Esophagus	18.0 nTPM
Heart muscle	14.1 nTPM
Placenta	13.7 nTPM
Liver	12.8 nTPM
Pancreas	11.6 nTPM
Endometrium	11.6 nTPM
Eye	11.3 nTPM
Ovary	11.3 nTPM
Lung	9.3 nTPM
Testis	8.9 nTPM
Breast	8.0 nTPM
Skeletal muscle	7.0 nTPM
Prostate	6.9 nTPM
Skin	6.9 nTPM

Fibroblasts	12.1 nTPM
Stomach	25.3 nTPM
Placenta	19.8 nTPM
Esophagus	16.1 nTPM
Heart muscle	15.0 nTPM
Skin	12.0 nTPM
Skeletal muscle	11.0 nTPM
Breast	8.1 nTPM
Adipose tissue	7.2 nTPM
Lung	6.7 nTPM
Prostate	6.7 nTPM
Ovary	5.2 nTPM

Intestinal goblet cells	10.9 nTPM
Rectum	14.3 nTPM
Small intestine	10.6 nTPM
Colon	7.8 nTPM

Macrophages	11.7 nTPM
Stomach	23.5 nTPM
Esophagus	18.9 nTPM
Pancreas	17.8 nTPM
Ovary	16.4 nTPM
Bone marrow	15.0 nTPM
Kidney	14.3 nTPM
Spleen	12.5 nTPM
Testis	12.2 nTPM
Lung	11.0 nTPM
Adipose tissue	9.7 nTPM
Prostate	8.1 nTPM
Endometrium	5.8 nTPM
Skeletal muscle	5.4 nTPM
Breast	5.3 nTPM
PBMC	0.0 nTPM

Paneth cells	13.3 nTPM
Small intestine	15.0 nTPM
Rectum	15.0 nTPM
Colon	9.9 nTPM

Plasma cells	10.9 nTPM
Spleen	16.0 nTPM
Bone marrow	13.2 nTPM
Stomach	12.3 nTPM
Adipose tissue	7.0 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	10.3 nTPM
Bronchus	14.8 nTPM
Lung	5.8 nTPM

Smooth muscle cells	8.4 nTPM
Pancreas	26.4 nTPM
Bronchus	19.9 nTPM
Heart muscle	7.9 nTPM
Ovary	6.8 nTPM
Esophagus	6.2 nTPM
Endometrium	5.6 nTPM
Prostate	4.3 nTPM
Skin	4.2 nTPM
Skeletal muscle	4.1 nTPM
Breast	3.9 nTPM
Adipose tissue	3.4 nTPM

T-cells	12.1 nTPM
Esophagus	39.3 nTPM
Stomach	22.5 nTPM
Bone marrow	20.2 nTPM
Spleen	14.9 nTPM
Colon	13.3 nTPM
Lung	10.6 nTPM
Kidney	10.2 nTPM
Lymph node	9.8 nTPM
Skin	9.7 nTPM
Adipose tissue	9.4 nTPM
PBMC	8.0 nTPM
Liver	7.7 nTPM
Skeletal muscle	7.5 nTPM
Ovary	6.7 nTPM
Breast	5.9 nTPM
Endometrium	5.4 nTPM
Prostate	4.7 nTPM

Basal keratinocytes	13.0 nTPM
Skin	13.0 nTPM

Basal respiratory cells	15.9 nTPM
Bronchus	15.9 nTPM

Basal squamous epithelial cells	14.2 nTPM
Esophagus	14.2 nTPM

Collecting duct cells	12.9 nTPM
Kidney	12.9 nTPM

Undifferentiated cells	8.5 nTPM
Rectum	12.0 nTPM
Small intestine	7.3 nTPM
Colon	6.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC