Single cell type - SLC10A3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SLC10A3
Gene descriptionⁱ Full gene name according to HGNC.	Solute carrier family 10 member 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Myeloid cells - Hemostasis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Syncytiotrophoblasts, Extravillous trophoblasts)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enriched (basophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Syncytiotrophoblasts, Extravillous trophoblasts)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

SLC10A3 is part of cluster 51 Myeloid cells - Hemostasis with confidenceⁱ 1
155 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
FAM110A	Family with sequence similarity 110 member A	0.6302	51
TMEM40	Transmembrane protein 40	0.6009	51
RPA1	Replication protein A1	0.5926	51
UBAC2	UBA domain containing 2	0.5911	51
IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	0.5806	51
BORCS6	BLOC-1 related complex subunit 6	0.5525	51
ARL6IP6	ADP ribosylation factor like GTPase 6 interacting protein 6	0.5319	47
CCND3	Cyclin D3	0.5273	51
C1GALT1	Core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1	0.5203	18
SIAH2	Siah E3 ubiquitin protein ligase 2	0.5186	18
TAGLN2	Transgelin 2	0.5167	51
BIN2	Bridging integrator 2	0.5157	63
EDAR	Ectodysplasin A receptor	0.5113	51
CSH1	Chorionic somatomammotropin hormone 1	0.5059	18
TINCR	TINCR ubiquitin domain containing	0.5045	18

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	13.3 nTPM
Adipose tissue	15.8 nTPM
Breast	10.7 nTPM

Alveolar cells type 1	3.2 nTPM
Lung	3.2 nTPM

Alveolar cells type 2	7.0 nTPM
Lung	7.0 nTPM

Astrocytes	2.3 nTPM
Brain	2.3 nTPM

B-cells	21.1 nTPM
Stomach	36.3 nTPM
Lymph node	35.9 nTPM
Spleen	30.1 nTPM
Colon	25.5 nTPM
Breast	22.8 nTPM
Liver	14.7 nTPM
Bone marrow	14.7 nTPM
Adipose tissue	14.1 nTPM
Kidney	9.5 nTPM
PBMC	7.1 nTPM

Dendritic cells	17.4 nTPM
Breast	25.2 nTPM
Adipose tissue	23.1 nTPM
PBMC	4.0 nTPM

Endothelial cells	15.8 nTPM
Pancreas	30.9 nTPM
Esophagus	28.4 nTPM
Liver	20.2 nTPM
Breast	17.0 nTPM
Eye	16.2 nTPM
Testis	15.7 nTPM
Placenta	15.3 nTPM
Skin	14.9 nTPM
Ovary	14.5 nTPM
Skeletal muscle	14.3 nTPM
Endometrium	12.1 nTPM
Prostate	10.1 nTPM
Lung	6.2 nTPM
Heart muscle	6.1 nTPM

Fibroblasts	21.2 nTPM
Placenta	45.3 nTPM
Stomach	41.6 nTPM
Esophagus	26.4 nTPM
Skin	24.2 nTPM
Adipose tissue	21.9 nTPM
Prostate	21.8 nTPM
Skeletal muscle	15.9 nTPM
Breast	14.0 nTPM
Lung	11.1 nTPM
Ovary	7.3 nTPM
Heart muscle	3.3 nTPM

Intestinal goblet cells	15.5 nTPM
Colon	15.7 nTPM
Rectum	15.7 nTPM
Small intestine	15.0 nTPM

Macrophages	22.7 nTPM
PBMC	136.4 nTPM
Prostate	37.9 nTPM
Adipose tissue	16.7 nTPM
Esophagus	15.8 nTPM
Ovary	15.6 nTPM
Pancreas	15.3 nTPM
Bone marrow	15.0 nTPM
Skeletal muscle	13.7 nTPM
Endometrium	11.9 nTPM
Testis	11.7 nTPM
Breast	11.6 nTPM
Spleen	11.4 nTPM
Lung	9.9 nTPM
Stomach	8.8 nTPM
Kidney	8.3 nTPM

Paneth cells	16.0 nTPM
Colon	19.7 nTPM
Rectum	17.0 nTPM
Small intestine	11.3 nTPM

Plasma cells	19.8 nTPM
Spleen	26.4 nTPM
Stomach	24.9 nTPM
Bone marrow	18.2 nTPM
Adipose tissue	17.4 nTPM
Esophagus	12.3 nTPM

Respiratory ciliated cells	6.9 nTPM
Bronchus	9.5 nTPM
Lung	4.4 nTPM

Smooth muscle cells	14.3 nTPM
Pancreas	30.4 nTPM
Skin	26.6 nTPM
Esophagus	21.7 nTPM
Prostate	14.4 nTPM
Adipose tissue	12.4 nTPM
Skeletal muscle	11.3 nTPM
Breast	10.4 nTPM
Bronchus	8.4 nTPM
Endometrium	8.3 nTPM
Ovary	7.1 nTPM
Heart muscle	5.8 nTPM

T-cells	24.5 nTPM
Stomach	41.9 nTPM
Spleen	38.3 nTPM
Skin	37.3 nTPM
Colon	32.8 nTPM
Esophagus	32.8 nTPM
Adipose tissue	31.0 nTPM
Bone marrow	30.3 nTPM
Lymph node	28.2 nTPM
Breast	25.0 nTPM
Skeletal muscle	19.1 nTPM
Prostate	19.0 nTPM
Endometrium	17.6 nTPM
Liver	15.9 nTPM
PBMC	15.2 nTPM
Kidney	14.4 nTPM
Lung	9.1 nTPM
Ovary	8.9 nTPM

Basal keratinocytes	22.6 nTPM
Skin	22.6 nTPM

Basal prostatic cells	27.1 nTPM
Prostate	27.1 nTPM

Basal squamous epithelial cells	50.7 nTPM
Esophagus	50.7 nTPM

Collecting duct cells	18.4 nTPM
Kidney	18.4 nTPM

Undifferentiated cells	11.7 nTPM
Rectum	14.4 nTPM
Small intestine	11.6 nTPM
Colon	9.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC