Single cell type - TOR1AIP1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TOR1AIP1
Gene descriptionⁱ Full gene name according to HGNC.	Torsin 1A interacting protein 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Early spermatids, Late spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Early spermatids, Late spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TOR1AIP1 is part of cluster 34 Spermatids - Unknown function with confidenceⁱ 1
366 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TMEM191C	Transmembrane protein 191C	0.5775	34
CCDC126	Coiled-coil domain containing 126	0.5765	34
ARL13A	ADP ribosylation factor like GTPase 13A	0.5753	34
RNF151	Ring finger protein 151	0.5641	34
LRRIQ4	Leucine rich repeats and IQ motif containing 4	0.5616	29
ZNF679	Zinc finger protein 679	0.5485	34
INPP1	Inositol polyphosphate-1-phosphatase	0.5462	34
C9orf153	Chromosome 9 open reading frame 153	0.5448	34
WDR64	WD repeat domain 64	0.5379	34
TTLL2	Tubulin tyrosine ligase like 2	0.5355	34
NOXRED1	NADP dependent oxidoreductase domain containing 1	0.5296	34
TRIM42	Tripartite motif containing 42	0.5270	34
CAMP	Cathelicidin antimicrobial peptide	0.5268	34
ZNF614	Zinc finger protein 614	0.5267	34
OR8B2	Olfactory receptor family 8 subfamily B member 2	0.5258	34

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	42.4 nTPM
Adipose tissue	55.6 nTPM
Breast	29.3 nTPM

Alveolar cells type 1	32.1 nTPM
Lung	32.1 nTPM

Alveolar cells type 2	36.1 nTPM
Lung	36.1 nTPM

Astrocytes	21.2 nTPM
Brain	21.2 nTPM

B-cells	33.9 nTPM
Bone marrow	58.1 nTPM
Stomach	52.6 nTPM
Spleen	40.5 nTPM
Lymph node	39.6 nTPM
PBMC	31.5 nTPM
Adipose tissue	29.1 nTPM
Kidney	28.5 nTPM
Colon	23.9 nTPM
Liver	20.0 nTPM
Breast	14.7 nTPM

Dendritic cells	44.1 nTPM
Adipose tissue	53.8 nTPM
Breast	42.7 nTPM
PBMC	35.8 nTPM

Endothelial cells	33.6 nTPM
Prostate	58.2 nTPM
Heart muscle	54.0 nTPM
Liver	45.8 nTPM
Esophagus	43.8 nTPM
Testis	36.4 nTPM
Endometrium	35.7 nTPM
Skeletal muscle	32.9 nTPM
Skin	26.4 nTPM
Breast	26.3 nTPM
Lung	24.9 nTPM
Ovary	23.8 nTPM
Eye	23.5 nTPM
Pancreas	23.1 nTPM
Placenta	14.8 nTPM

Fibroblasts	51.7 nTPM
Esophagus	82.3 nTPM
Prostate	70.1 nTPM
Adipose tissue	69.2 nTPM
Heart muscle	64.7 nTPM
Stomach	63.9 nTPM
Skeletal muscle	62.5 nTPM
Skin	46.0 nTPM
Breast	40.1 nTPM
Lung	27.9 nTPM
Ovary	22.9 nTPM
Placenta	19.2 nTPM

Intestinal goblet cells	10.6 nTPM
Rectum	13.3 nTPM
Colon	10.7 nTPM
Small intestine	7.9 nTPM

Macrophages	40.4 nTPM
Bone marrow	60.0 nTPM
Spleen	57.0 nTPM
Stomach	55.7 nTPM
Adipose tissue	52.1 nTPM
Esophagus	51.9 nTPM
Lung	46.1 nTPM
Ovary	43.2 nTPM
Prostate	35.5 nTPM
Testis	34.9 nTPM
Endometrium	34.8 nTPM
Skeletal muscle	32.4 nTPM
Breast	32.1 nTPM
Kidney	28.0 nTPM
Pancreas	28.0 nTPM
PBMC	13.6 nTPM

Paneth cells	12.5 nTPM
Small intestine	15.0 nTPM
Colon	13.2 nTPM
Rectum	9.4 nTPM

Plasma cells	32.8 nTPM
Adipose tissue	47.1 nTPM
Stomach	44.6 nTPM
Bone marrow	31.3 nTPM
Spleen	28.6 nTPM
Esophagus	12.3 nTPM

Respiratory ciliated cells	29.2 nTPM
Bronchus	30.7 nTPM
Lung	27.7 nTPM

Smooth muscle cells	38.0 nTPM
Esophagus	66.7 nTPM
Prostate	55.6 nTPM
Adipose tissue	50.6 nTPM
Skin	44.7 nTPM
Skeletal muscle	44.7 nTPM
Heart muscle	41.3 nTPM
Endometrium	36.6 nTPM
Breast	35.9 nTPM
Pancreas	19.8 nTPM
Ovary	16.6 nTPM
Bronchus	5.6 nTPM

T-cells	47.5 nTPM
Adipose tissue	66.2 nTPM
Stomach	62.6 nTPM
Bone marrow	62.0 nTPM
Spleen	60.2 nTPM
Endometrium	54.5 nTPM
Prostate	52.1 nTPM
Colon	51.8 nTPM
Lung	45.6 nTPM
Skeletal muscle	45.5 nTPM
Lymph node	45.0 nTPM
Ovary	42.2 nTPM
Skin	40.9 nTPM
Esophagus	39.3 nTPM
Breast	37.9 nTPM
Kidney	37.6 nTPM
Liver	35.4 nTPM
PBMC	28.6 nTPM

Basal keratinocytes	43.3 nTPM
Skin	43.3 nTPM

Basal prostatic cells	64.4 nTPM
Prostate	64.4 nTPM

Basal respiratory cells	21.3 nTPM
Bronchus	21.3 nTPM

Basal squamous epithelial cells	48.3 nTPM
Esophagus	48.3 nTPM

Undifferentiated cells	8.3 nTPM
Rectum	9.4 nTPM
Small intestine	8.2 nTPM
Colon	7.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC