Single cell type - PI4KB - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PI4KB
Gene descriptionⁱ Full gene name according to HGNC.	Phosphatidylinositol 4-kinase beta
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	11

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PI4KB is part of cluster 59 Non-specific - Transcription with confidenceⁱ 1
354 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ZNF687	Zinc finger protein 687	0.5416	52
CCAR2	Cell cycle and apoptosis regulator 2	0.5188	58
TFE3	Transcription factor binding to IGHM enhancer 3	0.4988	41
SGSH	N-sulfoglucosamine sulfohydrolase	0.4869	52
TRAF7	TNF receptor associated factor 7	0.4857	7
KPNB1	Karyopherin subunit beta 1	0.4771	55
SCYL1	SCY1 like pseudokinase 1	0.4713	55
ZNF322	Zinc finger protein 322	0.4611	59
FBRS	Fibrosin	0.4431	7
ERVK3-1	Endogenous retrovirus group K3 member 1	0.4369	59
TMEM115	Transmembrane protein 115	0.4306	55
NOP2	NOP2 nucleolar protein	0.4306	59
RXRB	Retinoid X receptor beta	0.4305	7
SF3B3	Splicing factor 3b subunit 3	0.4265	59
RAB5B	RAB5B, member RAS oncogene family	0.4253	22

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	16.8 nTPM
Adipose tissue	17.7 nTPM
Breast	15.9 nTPM

Alveolar cells type 1	16.0 nTPM
Lung	16.0 nTPM

Alveolar cells type 2	24.3 nTPM
Lung	24.3 nTPM

Astrocytes	19.2 nTPM
Brain	19.2 nTPM

B-cells	26.4 nTPM
Lymph node	41.2 nTPM
Spleen	37.7 nTPM
Bone marrow	35.1 nTPM
Stomach	25.9 nTPM
Adipose tissue	24.6 nTPM
Kidney	23.8 nTPM
Colon	20.8 nTPM
Liver	20.6 nTPM
PBMC	20.0 nTPM
Breast	14.7 nTPM

Dendritic cells	16.0 nTPM
Adipose tissue	22.9 nTPM
Breast	21.1 nTPM
PBMC	4.0 nTPM

Endothelial cells	19.3 nTPM
Liver	28.4 nTPM
Ovary	25.7 nTPM
Prostate	22.8 nTPM
Esophagus	20.6 nTPM
Testis	19.8 nTPM
Endometrium	19.8 nTPM
Skeletal muscle	19.6 nTPM
Heart muscle	18.7 nTPM
Lung	18.7 nTPM
Breast	17.4 nTPM
Placenta	17.0 nTPM
Skin	17.0 nTPM
Eye	13.7 nTPM
Pancreas	11.6 nTPM

Fibroblasts	25.9 nTPM
Stomach	34.1 nTPM
Esophagus	33.6 nTPM
Prostate	31.4 nTPM
Ovary	31.4 nTPM
Adipose tissue	27.2 nTPM
Skin	26.5 nTPM
Placenta	26.0 nTPM
Breast	25.0 nTPM
Skeletal muscle	24.2 nTPM
Lung	16.8 nTPM
Heart muscle	9.1 nTPM

Intestinal goblet cells	16.4 nTPM
Rectum	21.3 nTPM
Small intestine	15.3 nTPM
Colon	12.9 nTPM

Macrophages	21.3 nTPM
Ovary	39.0 nTPM
Spleen	35.3 nTPM
Adipose tissue	31.5 nTPM
Esophagus	28.3 nTPM
Skeletal muscle	28.1 nTPM
Breast	23.7 nTPM
Bone marrow	22.5 nTPM
Testis	22.1 nTPM
Endometrium	19.1 nTPM
Lung	18.7 nTPM
Prostate	18.4 nTPM
Kidney	15.8 nTPM
Stomach	11.7 nTPM
Pancreas	5.1 nTPM
PBMC	0.0 nTPM

Paneth cells	17.3 nTPM
Rectum	19.9 nTPM
Small intestine	18.8 nTPM
Colon	13.2 nTPM

Plasma cells	24.4 nTPM
Adipose tissue	27.7 nTPM
Spleen	27.3 nTPM
Bone marrow	24.7 nTPM
Stomach	24.1 nTPM
Esophagus	18.4 nTPM

Respiratory ciliated cells	17.1 nTPM
Bronchus	23.9 nTPM
Lung	10.2 nTPM

Smooth muscle cells	23.2 nTPM
Esophagus	35.7 nTPM
Pancreas	29.3 nTPM
Skin	29.3 nTPM
Skeletal muscle	25.5 nTPM
Prostate	24.4 nTPM
Ovary	23.6 nTPM
Breast	22.1 nTPM
Adipose tissue	21.3 nTPM
Endometrium	18.9 nTPM
Heart muscle	15.8 nTPM
Bronchus	9.4 nTPM

T-cells	23.8 nTPM
Lymph node	37.6 nTPM
Spleen	32.0 nTPM
Liver	28.8 nTPM
Bone marrow	26.0 nTPM
Skeletal muscle	25.2 nTPM
Stomach	24.6 nTPM
Ovary	24.5 nTPM
Adipose tissue	23.8 nTPM
Prostate	23.6 nTPM
Breast	23.5 nTPM
Colon	22.8 nTPM
PBMC	22.0 nTPM
Esophagus	19.7 nTPM
Kidney	19.1 nTPM
Endometrium	17.6 nTPM
Lung	16.7 nTPM
Skin	16.6 nTPM

Basal keratinocytes	22.3 nTPM
Skin	22.3 nTPM

Basal prostatic cells	18.2 nTPM
Prostate	18.2 nTPM

Basal squamous epithelial cells	28.5 nTPM
Esophagus	28.5 nTPM

Cholangiocytes	21.5 nTPM
Liver	21.5 nTPM

Undifferentiated cells	20.2 nTPM
Rectum	21.5 nTPM
Small intestine	21.4 nTPM
Colon	17.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC