Cell line - EIF2B5 - The Human Protein Atlas

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EIF2B5

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BRAIN

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METABOLIC

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EIF2B5
Gene descriptionⁱ Full gene name according to HGNC.	Eukaryotic translation initiation factor 2B subunit epsilon
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	SK-BR-3 - Unknown function (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

EIF2B5 is part of cluster 8 SK-BR-3 - Unknown function with confidenceⁱ 1
376 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MCCC1	Methylcrotonoyl-CoA carboxylase 1	0.7362	6
MRPL13	Mitochondrial ribosomal protein L13	0.7174	8
POLR2H	RNA polymerase II, I and III subunit H	0.7057	26
NDUFB5	NADH:ubiquinone oxidoreductase subunit B5	0.6947	26
CREB3L4	CAMP responsive element binding protein 3 like 4	0.6551	8
DNAJC19	DnaJ heat shock protein family (Hsp40) member C19	0.6502	26
MFN1	Mitofusin 1	0.6492	6
DARS2	Aspartyl-tRNA synthetase 2, mitochondrial	0.6490	26
TMEM70	Transmembrane protein 70	0.6474	8
OPA1	OPA1 mitochondrial dynamin like GTPase	0.6453	26
MRPS28	Mitochondrial ribosomal protein S28	0.6431	8
DSCC1	DNA replication and sister chromatid cohesion 1	0.6332	8
CRCP	CGRP receptor component	0.6287	8
NSMCE2	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase	0.6265	8
TSPAN13	Tetraspanin 13	0.6255	6

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.