Single cell type - FIP1L1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FIP1L1
Gene descriptionⁱ Full gene name according to HGNC.	Factor interacting with PAPOLA and CPSF1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

FIP1L1 is part of cluster 10 Non-specific - Unknown function with confidenceⁱ 1
482 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SBNO1	Strawberry notch homolog 1	0.6477	20
RCN2	Reticulocalbin 2	0.5379	13
QRICH1	Glutamine rich 1	0.5335	59
ATXN7L2	Ataxin 7 like 2	0.5279	10
NAA16	N-alpha-acetyltransferase 16, NatA auxiliary subunit	0.4979	52
PLAA	Phospholipase A2 activating protein	0.4899	10
ESF1	ESF1 nucleolar pre-rRNA processing protein homolog	0.4765	10
EXD2	Exonuclease 3'-5' domain containing 2	0.4705	66
ACTR5	Actin related protein 5	0.4696	66
CPSF6	Cleavage and polyadenylation specific factor 6	0.4612	10
UTP18	UTP18 small subunit processome component	0.4565	10
COL20A1	Collagen type XX alpha 1 chain	0.4526	68
SMC6	Structural maintenance of chromosomes 6	0.4525	10
AGPAT5	1-acylglycerol-3-phosphate O-acyltransferase 5	0.4520	44
ZFP1	ZFP1 zinc finger protein	0.4429	59

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	36.1 nTPM
Adipose tissue	38.7 nTPM
Breast	33.5 nTPM

Alveolar cells type 1	25.6 nTPM
Lung	25.6 nTPM

Alveolar cells type 2	25.4 nTPM
Lung	25.4 nTPM

Astrocytes	47.0 nTPM
Brain	47.0 nTPM

B-cells	50.4 nTPM
Lymph node	66.5 nTPM
Stomach	65.4 nTPM
Kidney	61.9 nTPM
Spleen	60.9 nTPM
Adipose tissue	54.6 nTPM
Bone marrow	51.5 nTPM
Liver	47.2 nTPM
Breast	38.8 nTPM
Colon	31.9 nTPM
PBMC	25.7 nTPM

Dendritic cells	54.0 nTPM
Breast	56.9 nTPM
Adipose tissue	53.3 nTPM
PBMC	51.8 nTPM

Endothelial cells	33.4 nTPM
Pancreas	65.6 nTPM
Prostate	43.0 nTPM
Eye	36.4 nTPM
Placenta	35.8 nTPM
Skeletal muscle	35.5 nTPM
Esophagus	34.5 nTPM
Endometrium	31.8 nTPM
Ovary	31.8 nTPM
Testis	31.2 nTPM
Lung	28.1 nTPM
Liver	26.6 nTPM
Breast	25.8 nTPM
Skin	22.4 nTPM
Heart muscle	19.5 nTPM

Fibroblasts	41.9 nTPM
Placenta	57.2 nTPM
Prostate	56.2 nTPM
Adipose tissue	53.3 nTPM
Lung	50.3 nTPM
Esophagus	44.3 nTPM
Skeletal muscle	42.0 nTPM
Ovary	41.6 nTPM
Breast	39.7 nTPM
Stomach	34.1 nTPM
Skin	27.3 nTPM
Heart muscle	14.9 nTPM

Intestinal goblet cells	27.0 nTPM
Colon	28.6 nTPM
Small intestine	28.5 nTPM
Rectum	24.0 nTPM

Macrophages	32.2 nTPM
Pancreas	43.4 nTPM
Lung	41.5 nTPM
PBMC	40.9 nTPM
Endometrium	40.0 nTPM
Breast	39.3 nTPM
Testis	36.0 nTPM
Adipose tissue	33.5 nTPM
Esophagus	33.1 nTPM
Stomach	32.2 nTPM
Prostate	27.5 nTPM
Ovary	27.5 nTPM
Skeletal muscle	26.2 nTPM
Bone marrow	23.7 nTPM
Kidney	19.6 nTPM
Spleen	18.6 nTPM

Paneth cells	33.3 nTPM
Small intestine	45.0 nTPM
Rectum	35.1 nTPM
Colon	19.7 nTPM

Plasma cells	40.3 nTPM
Adipose tissue	48.3 nTPM
Bone marrow	42.9 nTPM
Stomach	39.9 nTPM
Spleen	39.7 nTPM
Esophagus	30.7 nTPM

Respiratory ciliated cells	44.8 nTPM
Lung	49.5 nTPM
Bronchus	40.1 nTPM

Smooth muscle cells	46.9 nTPM
Bronchus	202.6 nTPM
Ovary	45.1 nTPM
Esophagus	41.9 nTPM
Pancreas	37.4 nTPM
Skeletal muscle	32.6 nTPM
Adipose tissue	32.2 nTPM
Prostate	31.6 nTPM
Endometrium	29.1 nTPM
Breast	28.3 nTPM
Skin	20.6 nTPM
Heart muscle	14.4 nTPM

T-cells	49.8 nTPM
Ovary	82.3 nTPM
Lung	62.3 nTPM
Stomach	61.6 nTPM
Adipose tissue	56.4 nTPM
Breast	56.4 nTPM
Lymph node	54.9 nTPM
Bone marrow	53.6 nTPM
Spleen	53.0 nTPM
Liver	49.9 nTPM
Kidney	48.6 nTPM
Endometrium	48.2 nTPM
Colon	45.1 nTPM
Skeletal muscle	42.5 nTPM
PBMC	39.5 nTPM
Esophagus	32.8 nTPM
Skin	31.3 nTPM
Prostate	28.4 nTPM

Basal prostatic cells	46.6 nTPM
Prostate	46.6 nTPM

Basal squamous epithelial cells	30.1 nTPM
Esophagus	30.1 nTPM

Cholangiocytes	21.5 nTPM
Liver	21.5 nTPM

Collecting duct cells	27.6 nTPM
Kidney	27.6 nTPM

Undifferentiated cells	29.4 nTPM
Small intestine	33.1 nTPM
Colon	28.0 nTPM
Rectum	27.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC