Single cell type - CAMK2D - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CAMK2D
Gene descriptionⁱ Full gene name according to HGNC.	Calcium/calmodulin dependent protein kinase II delta
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	12

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Neurons & Oligodendrocytes - Synaptic function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cardiomyocytes, Oligodendrocyte precursor cells, Inhibitory neurons, Microglial cells, Excitatory neurons)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (ASC TERT1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cardiomyocytes, Oligodendrocyte precursor cells, Inhibitory neurons, Microglial cells, Excitatory neurons)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CAMK2D is part of cluster 8 Neurons & Oligodendrocytes - Synaptic function with confidenceⁱ 1
719 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CHRM2	Cholinergic receptor muscarinic 2	0.6201	8
VWC2L	Von Willebrand factor C domain containing 2 like	0.5992	8
HTR2C	5-hydroxytryptamine receptor 2C	0.5973	8
QRFPR	Pyroglutamylated RFamide peptide receptor	0.5883	8
NPSR1	Neuropeptide S receptor 1	0.5740	8
PCDH11X	Protocadherin 11 X-linked	0.5570	8
SMIM17	Small integral membrane protein 17	0.5428	8
GHR	Growth hormone receptor	0.5423	8
GRM8	Glutamate metabotropic receptor 8	0.5422	8
CCKAR	Cholecystokinin A receptor	0.5395	21
KIAA1217	KIAA1217	0.5290	8
ADCY2	Adenylate cyclase 2	0.5199	21
ROBO2	Roundabout guidance receptor 2	0.5198	8
FAM189A1	Family with sequence similarity 189 member A1	0.5134	8
PCDH11Y	Protocadherin 11 Y-linked	0.5046	8

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	43.7 nTPM
Adipose tissue	64.4 nTPM
Breast	23.0 nTPM

Alveolar cells type 1	41.7 nTPM
Lung	41.7 nTPM

Alveolar cells type 2	37.6 nTPM
Lung	37.6 nTPM

Astrocytes	128.3 nTPM
Brain	128.3 nTPM

B-cells	55.1 nTPM
Adipose tissue	86.2 nTPM
PBMC	84.2 nTPM
Bone marrow	82.5 nTPM
Lymph node	72.1 nTPM
Spleen	65.1 nTPM
Stomach	42.7 nTPM
Breast	37.5 nTPM
Colon	33.5 nTPM
Kidney	33.4 nTPM
Liver	13.7 nTPM

Dendritic cells	19.0 nTPM
Adipose tissue	27.1 nTPM
Breast	25.9 nTPM
PBMC	4.0 nTPM

Endothelial cells	27.2 nTPM
Prostate	59.1 nTPM
Heart muscle	53.3 nTPM
Skin	40.9 nTPM
Eye	29.9 nTPM
Esophagus	28.7 nTPM
Lung	28.1 nTPM
Breast	26.7 nTPM
Liver	25.7 nTPM
Skeletal muscle	23.7 nTPM
Endometrium	17.7 nTPM
Ovary	13.9 nTPM
Placenta	13.1 nTPM
Testis	12.5 nTPM
Pancreas	7.7 nTPM

Enteroendocrine cells	103.8 nTPM
Colon	142.1 nTPM
Rectum	65.6 nTPM

Fibroblasts	50.1 nTPM
Heart muscle	117.8 nTPM
Adipose tissue	117.3 nTPM
Esophagus	48.3 nTPM
Breast	42.1 nTPM
Skin	41.9 nTPM
Skeletal muscle	41.7 nTPM
Lung	39.1 nTPM
Prostate	36.1 nTPM
Stomach	26.7 nTPM
Placenta	25.6 nTPM
Ovary	14.3 nTPM

Intestinal goblet cells	88.1 nTPM
Rectum	99.6 nTPM
Small intestine	85.3 nTPM
Colon	79.4 nTPM

Macrophages	31.5 nTPM
Endometrium	57.1 nTPM
Breast	55.4 nTPM
Adipose tissue	50.9 nTPM
Esophagus	40.9 nTPM
Stomach	38.1 nTPM
Spleen	37.4 nTPM
Kidney	34.0 nTPM
Skeletal muscle	33.8 nTPM
Testis	30.8 nTPM
Bone marrow	26.2 nTPM
Lung	25.1 nTPM
Ovary	21.5 nTPM
Prostate	18.4 nTPM
Pancreas	2.5 nTPM
PBMC	0.0 nTPM

Paneth cells	57.3 nTPM
Rectum	80.3 nTPM
Small intestine	48.8 nTPM
Colon	42.8 nTPM

Plasma cells	20.4 nTPM
Esophagus	30.7 nTPM
Stomach	25.9 nTPM
Adipose tissue	18.8 nTPM
Spleen	16.9 nTPM
Bone marrow	9.9 nTPM

Respiratory ciliated cells	21.7 nTPM
Lung	21.9 nTPM
Bronchus	21.6 nTPM

Smooth muscle cells	44.4 nTPM
Bronchus	86.6 nTPM
Adipose tissue	82.1 nTPM
Esophagus	52.7 nTPM
Skeletal muscle	51.5 nTPM
Heart muscle	37.5 nTPM
Prostate	37.5 nTPM
Skin	35.6 nTPM
Endometrium	34.6 nTPM
Breast	30.3 nTPM
Ovary	24.0 nTPM
Pancreas	16.3 nTPM

Basal prostatic cells	16.6 nTPM
Prostate	16.6 nTPM

Basal respiratory cells	8.3 nTPM
Bronchus	8.3 nTPM

Basal squamous epithelial cells	22.8 nTPM
Esophagus	22.8 nTPM

Cholangiocytes	62.9 nTPM
Liver	62.9 nTPM

T-cells	27.8 nTPM
Lymph node	53.8 nTPM
Adipose tissue	37.2 nTPM
Bone marrow	37.2 nTPM
Stomach	37.1 nTPM
Spleen	34.4 nTPM
PBMC	34.1 nTPM
Breast	32.6 nTPM
Prostate	28.4 nTPM
Skeletal muscle	28.1 nTPM
Liver	26.9 nTPM
Endometrium	26.9 nTPM
Ovary	24.5 nTPM
Colon	19.0 nTPM
Skin	18.8 nTPM
Esophagus	13.1 nTPM
Kidney	10.9 nTPM
Lung	9.1 nTPM

Undifferentiated cells	48.6 nTPM
Rectum	59.1 nTPM
Small intestine	44.8 nTPM
Colon	41.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC