Single cell type - CHST7 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CHST7
Gene descriptionⁱ Full gene name according to HGNC.	Carbohydrate sulfotransferase 7
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Fibroblasts - ECM organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Peritubular cells, monocytes, Sertoli cells, Langerhans cells, Skeletal myocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (T-reg)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (EFO-21, NTERA-2, PC-3)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Peritubular cells, monocytes, Sertoli cells, Langerhans cells, Skeletal myocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CHST7 is part of cluster 50 Fibroblasts - ECM organization with confidenceⁱ 1
441 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
GSN	Gelsolin	0.6296	50
TNXB	Tenascin XB	0.6156	50
CFD	Complement factor D	0.6136	50
XG	Xg glycoprotein (Xg blood group)	0.6128	50
CXCL12	C-X-C motif chemokine ligand 12	0.6076	50
CLEC3B	C-type lectin domain family 3 member B	0.6068	50
ACKR3	Atypical chemokine receptor 3	0.5962	50
PDGFRL	Platelet derived growth factor receptor like	0.5942	50
OMD	Osteomodulin	0.5934	50
C17orf58	Chromosome 17 open reading frame 58	0.5906	50
C5orf58	Chromosome 5 open reading frame 58	0.5892	50
TIMP2	TIMP metallopeptidase inhibitor 2	0.5888	50
PPDPFL	Pancreatic progenitor cell differentiation and proliferation factor like	0.5862	50
H3Y1	H3.Y histone 1	0.5843	50
CCN5	Cellular communication network factor 5	0.5831	50

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	33.8 nTPM
Adipose tissue	38.6 nTPM
Breast	29.1 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	3.1 nTPM
Lung	3.1 nTPM

Astrocytes	22.9 nTPM
Brain	22.9 nTPM

B-cells	2.5 nTPM
Colon	4.8 nTPM
Kidney	4.8 nTPM
Liver	2.9 nTPM
PBMC	2.8 nTPM
Breast	2.6 nTPM
Adipose tissue	2.0 nTPM
Bone marrow	1.7 nTPM
Spleen	1.4 nTPM
Lymph node	1.0 nTPM
Stomach	0.9 nTPM

Dendritic cells	11.5 nTPM
Adipose tissue	20.5 nTPM
Breast	13.9 nTPM
PBMC	0.0 nTPM

Endothelial cells	16.3 nTPM
Breast	31.3 nTPM
Prostate	24.5 nTPM
Skin	23.9 nTPM
Endometrium	22.2 nTPM
Liver	22.0 nTPM
Esophagus	19.5 nTPM
Ovary	19.0 nTPM
Skeletal muscle	17.0 nTPM
Pancreas	11.6 nTPM
Eye	10.5 nTPM
Heart muscle	10.3 nTPM
Placenta	8.6 nTPM
Testis	4.4 nTPM
Lung	3.1 nTPM

Fibroblasts	23.6 nTPM
Adipose tissue	82.9 nTPM
Prostate	43.3 nTPM
Esophagus	27.2 nTPM
Skin	25.8 nTPM
Skeletal muscle	24.7 nTPM
Ovary	17.6 nTPM
Heart muscle	14.0 nTPM
Breast	11.1 nTPM
Stomach	8.9 nTPM
Placenta	3.7 nTPM
Lung	0.0 nTPM

Intestinal goblet cells	2.9 nTPM
Colon	3.6 nTPM
Rectum	2.5 nTPM
Small intestine	2.4 nTPM

Macrophages	14.1 nTPM
Prostate	42.3 nTPM
Spleen	27.9 nTPM
Stomach	26.4 nTPM
Adipose tissue	21.7 nTPM
Bone marrow	21.2 nTPM
Kidney	15.2 nTPM
Breast	12.3 nTPM
Esophagus	9.4 nTPM
Skeletal muscle	9.3 nTPM
Endometrium	8.9 nTPM
Pancreas	7.7 nTPM
Ovary	4.1 nTPM
Lung	3.3 nTPM
Testis	2.3 nTPM
PBMC	0.0 nTPM

Paneth cells	1.5 nTPM
Colon	3.3 nTPM
Rectum	1.2 nTPM
Small intestine	0.0 nTPM

Plasma cells	4.7 nTPM
Adipose tissue	11.6 nTPM
Stomach	5.2 nTPM
Bone marrow	3.3 nTPM
Spleen	3.2 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	1.9 nTPM
Bronchus	2.4 nTPM
Lung	1.5 nTPM

Smooth muscle cells	11.2 nTPM
Prostate	24.7 nTPM
Skin	16.8 nTPM
Endometrium	14.0 nTPM
Adipose tissue	13.9 nTPM
Ovary	12.4 nTPM
Breast	11.9 nTPM
Heart muscle	9.2 nTPM
Pancreas	9.1 nTPM
Skeletal muscle	5.7 nTPM
Esophagus	3.1 nTPM
Bronchus	2.9 nTPM

T-cells	9.9 nTPM
Skin	24.9 nTPM
Adipose tissue	21.3 nTPM
Colon	16.1 nTPM
Prostate	14.2 nTPM
Breast	13.8 nTPM
Skeletal muscle	11.9 nTPM
Ovary	11.1 nTPM
Kidney	10.2 nTPM
Endometrium	8.2 nTPM
Spleen	7.4 nTPM
Bone marrow	7.3 nTPM
PBMC	6.0 nTPM
Liver	5.7 nTPM
Lymph node	5.3 nTPM
Stomach	5.0 nTPM
Lung	0.0 nTPM
Esophagus	0.0 nTPM

Cholangiocytes	10.0 nTPM
Liver	10.0 nTPM

Collecting duct cells	1.8 nTPM
Kidney	1.8 nTPM

Endometrial stromal cells	20.8 nTPM
Endometrium	20.8 nTPM

Undifferentiated cells	0.9 nTPM
Colon	1.3 nTPM
Rectum	0.9 nTPM
Small intestine	0.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC