Single cell type - OGT - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	OGT
Gene descriptionⁱ Full gene name according to HGNC.	O-linked N-acetylglucosamine (GlcNAc) transferase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Plasmacytoid DCs - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

OGT is part of cluster 65 Plasmacytoid DCs - Unknown function with confidenceⁱ 1
144 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MSL2	MSL complex subunit 2	0.5888	24
H2AC16	H2A clustered histone 16	0.5171	24
RPS6KB1	Ribosomal protein S6 kinase B1	0.5120	59
KLF13	Kruppel like factor 13	0.5071	24
INPP4A	Inositol polyphosphate-4-phosphatase type I A	0.5061	65
CXCR3	C-X-C motif chemokine receptor 3	0.5059	65
MARCHF9	Membrane associated ring-CH-type finger 9	0.5041	24
FBXO33	F-box protein 33	0.5033	24
SP3	Sp3 transcription factor	0.4992	59
ATP11B	ATPase phospholipid transporting 11B (putative)	0.4988	59
FBXW11	F-box and WD repeat domain containing 11	0.4981	65
IRF4	Interferon regulatory factor 4	0.4977	65
H4C4	H4 clustered histone 4	0.4974	65
BTAF1	B-TFIID TATA-box binding protein associated factor 1	0.4952	44
KANTR	KDM5C adjacent transcript	0.4886	7

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	31.1 nTPM
Adipose tissue	43.5 nTPM
Breast	18.7 nTPM

Alveolar cells type 1	35.3 nTPM
Lung	35.3 nTPM

Alveolar cells type 2	85.2 nTPM
Lung	85.2 nTPM

Astrocytes	52.9 nTPM
Brain	52.9 nTPM

B-cells	67.2 nTPM
Adipose tissue	148.3 nTPM
Bone marrow	117.7 nTPM
Spleen	80.0 nTPM
Breast	73.5 nTPM
Stomach	70.0 nTPM
Liver	56.7 nTPM
Lymph node	50.9 nTPM
PBMC	38.6 nTPM
Colon	27.1 nTPM
Kidney	9.5 nTPM

Dendritic cells	130.7 nTPM
Adipose tissue	170.0 nTPM
PBMC	147.4 nTPM
Breast	74.7 nTPM

Endothelial cells	39.8 nTPM
Prostate	83.8 nTPM
Heart muscle	70.9 nTPM
Skin	57.0 nTPM
Endometrium	51.2 nTPM
Testis	46.5 nTPM
Liver	45.8 nTPM
Placenta	32.4 nTPM
Ovary	32.3 nTPM
Breast	28.6 nTPM
Skeletal muscle	28.2 nTPM
Lung	28.1 nTPM
Esophagus	22.8 nTPM
Eye	21.8 nTPM
Pancreas	7.7 nTPM

Fibroblasts	47.5 nTPM
Heart muscle	89.2 nTPM
Prostate	61.4 nTPM
Adipose tissue	60.9 nTPM
Lung	54.7 nTPM
Stomach	53.4 nTPM
Skin	49.5 nTPM
Skeletal muscle	38.7 nTPM
Ovary	37.2 nTPM
Breast	31.9 nTPM
Esophagus	27.1 nTPM
Placenta	18.6 nTPM

Intestinal goblet cells	37.3 nTPM
Rectum	46.2 nTPM
Colon	33.6 nTPM
Small intestine	32.1 nTPM

Macrophages	45.8 nTPM
Adipose tissue	98.3 nTPM
Bone marrow	86.2 nTPM
Spleen	71.6 nTPM
Skeletal muscle	54.1 nTPM
Stomach	46.9 nTPM
Endometrium	46.1 nTPM
Testis	42.4 nTPM
Esophagus	39.3 nTPM
Breast	37.0 nTPM
Lung	36.9 nTPM
Prostate	36.7 nTPM
Kidney	36.3 nTPM
Ovary	31.9 nTPM
PBMC	13.6 nTPM
Pancreas	10.2 nTPM

Paneth cells	34.9 nTPM
Colon	36.2 nTPM
Rectum	34.8 nTPM
Small intestine	33.8 nTPM

Plasma cells	147.2 nTPM
Adipose tissue	232.2 nTPM
Stomach	183.8 nTPM
Bone marrow	112.1 nTPM
Esophagus	104.7 nTPM
Spleen	103.3 nTPM

Respiratory ciliated cells	28.0 nTPM
Bronchus	34.2 nTPM
Lung	21.9 nTPM

Smooth muscle cells	42.2 nTPM
Bronchus	125.5 nTPM
Heart muscle	56.9 nTPM
Adipose tissue	55.8 nTPM
Skin	46.3 nTPM
Prostate	36.6 nTPM
Endometrium	30.2 nTPM
Skeletal muscle	28.9 nTPM
Ovary	26.2 nTPM
Breast	22.9 nTPM
Esophagus	21.7 nTPM
Pancreas	13.2 nTPM

T-cells	82.1 nTPM
Adipose tissue	243.0 nTPM
Bone marrow	103.0 nTPM
Skeletal muscle	102.7 nTPM
Endometrium	99.6 nTPM
Skin	87.0 nTPM
Spleen	82.8 nTPM
Breast	74.0 nTPM
Stomach	73.7 nTPM
Liver	70.9 nTPM
Lung	68.4 nTPM
Lymph node	66.7 nTPM
Colon	64.2 nTPM
Prostate	61.6 nTPM
PBMC	57.1 nTPM
Esophagus	52.4 nTPM
Ovary	48.9 nTPM
Kidney	39.7 nTPM

Basal keratinocytes	88.1 nTPM
Skin	88.1 nTPM

Basal prostatic cells	37.9 nTPM
Prostate	37.9 nTPM

Basal respiratory cells	23.5 nTPM
Bronchus	23.5 nTPM

Basal squamous epithelial cells	58.6 nTPM
Esophagus	58.6 nTPM

Undifferentiated cells	34.0 nTPM
Rectum	42.0 nTPM
Small intestine	32.8 nTPM
Colon	27.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC