Single cell type - RPS6KB1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RPS6KB1
Gene descriptionⁱ Full gene name according to HGNC.	Ribosomal protein S6 kinase B1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enriched (MCF7)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

RPS6KB1 is part of cluster 59 Non-specific - Transcription with confidenceⁱ 0.96
354 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PRDM2	PR/SET domain 2	0.5607	57
GATAD2B	GATA zinc finger domain containing 2B	0.5488	59
SETD2	SET domain containing 2, histone lysine methyltransferase	0.5459	52
FBXW11	F-box and WD repeat domain containing 11	0.5269	65
RLF	RLF zinc finger	0.5195	44
SMNDC1	Survival motor neuron domain containing 1	0.5126	10
OGT	O-linked N-acetylglucosamine (GlcNAc) transferase	0.5120	65
UBE3A	Ubiquitin protein ligase E3A	0.5118	10
TRPM7	Transient receptor potential cation channel subfamily M member 7	0.5105	21
RINT1	RAD50 interactor 1	0.5099	59
PRPF40A	Pre-mRNA processing factor 40 homolog A	0.5026	10
CNOT2	CCR4-NOT transcription complex subunit 2	0.4988	44
SMCHD1	Structural maintenance of chromosomes flexible hinge domain containing 1	0.4964	24
MSL2	MSL complex subunit 2	0.4960	24
FAM13B	Family with sequence similarity 13 member B	0.4954	59

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	22.8 nTPM
Adipose tissue	26.9 nTPM
Breast	18.7 nTPM

Alveolar cells type 1	22.4 nTPM
Lung	22.4 nTPM

Alveolar cells type 2	34.2 nTPM
Lung	34.2 nTPM

Astrocytes	29.0 nTPM
Brain	29.0 nTPM

B-cells	32.6 nTPM
Adipose tissue	77.7 nTPM
Lymph node	41.3 nTPM
Stomach	40.4 nTPM
Spleen	30.8 nTPM
Breast	30.7 nTPM
PBMC	24.3 nTPM
Colon	23.9 nTPM
Bone marrow	21.3 nTPM
Kidney	19.0 nTPM
Liver	16.7 nTPM

Dendritic cells	33.5 nTPM
Adipose tissue	48.5 nTPM
Breast	28.1 nTPM
PBMC	23.9 nTPM

Endothelial cells	25.5 nTPM
Lung	53.0 nTPM
Pancreas	38.6 nTPM
Endometrium	34.7 nTPM
Prostate	33.1 nTPM
Skin	25.2 nTPM
Skeletal muscle	24.4 nTPM
Heart muscle	21.5 nTPM
Ovary	21.5 nTPM
Testis	20.4 nTPM
Breast	20.2 nTPM
Liver	17.4 nTPM
Esophagus	17.0 nTPM
Eye	16.2 nTPM
Placenta	14.2 nTPM

Fibroblasts	24.8 nTPM
Heart muscle	41.7 nTPM
Lung	31.3 nTPM
Prostate	29.7 nTPM
Skeletal muscle	27.5 nTPM
Adipose tissue	26.7 nTPM
Skin	24.1 nTPM
Esophagus	22.5 nTPM
Placenta	19.1 nTPM
Breast	17.9 nTPM
Ovary	17.1 nTPM
Stomach	14.9 nTPM

Intestinal goblet cells	14.1 nTPM
Rectum	17.9 nTPM
Small intestine	16.6 nTPM
Colon	7.8 nTPM

Macrophages	19.0 nTPM
Adipose tissue	38.0 nTPM
Endometrium	25.6 nTPM
Esophagus	25.2 nTPM
Lung	22.9 nTPM
Spleen	22.8 nTPM
Breast	22.3 nTPM
Skeletal muscle	21.3 nTPM
Kidney	20.4 nTPM
Stomach	17.6 nTPM
Testis	16.9 nTPM
Ovary	15.4 nTPM
Bone marrow	13.8 nTPM
Prostate	12.6 nTPM
Pancreas	10.2 nTPM
PBMC	0.0 nTPM

Paneth cells	10.9 nTPM
Rectum	15.0 nTPM
Small intestine	11.3 nTPM
Colon	6.5 nTPM

Plasma cells	34.6 nTPM
Adipose tissue	54.3 nTPM
Stomach	34.4 nTPM
Bone marrow	31.3 nTPM
Spleen	28.3 nTPM
Esophagus	24.6 nTPM

Respiratory ciliated cells	21.1 nTPM
Lung	27.7 nTPM
Bronchus	14.5 nTPM

Smooth muscle cells	32.6 nTPM
Bronchus	113.7 nTPM
Heart muscle	39.6 nTPM
Endometrium	30.2 nTPM
Adipose tissue	29.7 nTPM
Skin	28.9 nTPM
Prostate	25.6 nTPM
Skeletal muscle	22.9 nTPM
Pancreas	18.8 nTPM
Ovary	18.3 nTPM
Breast	17.1 nTPM
Esophagus	14.0 nTPM

T-cells	29.9 nTPM
Adipose tissue	62.7 nTPM
Lymph node	41.7 nTPM
Endometrium	40.5 nTPM
Stomach	36.2 nTPM
Lung	33.4 nTPM
Breast	32.8 nTPM
Skeletal muscle	31.9 nTPM
Colon	30.9 nTPM
Spleen	30.0 nTPM
Esophagus	26.2 nTPM
Skin	24.4 nTPM
PBMC	22.7 nTPM
Bone marrow	22.4 nTPM
Ovary	22.3 nTPM
Kidney	19.8 nTPM
Liver	15.8 nTPM
Prostate	14.2 nTPM

Basal keratinocytes	33.0 nTPM
Skin	33.0 nTPM

Basal prostatic cells	21.4 nTPM
Prostate	21.4 nTPM

Basal respiratory cells	13.0 nTPM
Bronchus	13.0 nTPM

Cholangiocytes	12.8 nTPM
Liver	12.8 nTPM

Undifferentiated cells	13.9 nTPM
Rectum	17.6 nTPM
Small intestine	12.8 nTPM
Colon	11.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC