Single cell type - ATP6V1B2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ATP6V1B2
Gene descriptionⁱ Full gene name according to HGNC.	ATPase H+ transporting V1 subunit B2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes FDA approved drug targets Human disease related genes Metabolic proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Proximal tubular cells - Tubular reabsorption (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal tubular cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (neutrophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (SK-MEL-30)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal tubular cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ATP6V1B2 is part of cluster 67 Proximal tubular cells - Tubular reabsorption with confidenceⁱ 1
499 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
FTL	Ferritin light chain	0.6381	4
RENBP	Renin binding protein	0.6237	67
FN3K	Fructosamine 3 kinase	0.5986	67
HSD17B14	Hydroxysteroid 17-beta dehydrogenase 14	0.5848	67
FBXL5	F-box and leucine rich repeat protein 5	0.5790	67
NQO2	N-ribosyldihydronicotinamide:quinone reductase 2	0.5756	67
MCRIP2	MAPK regulated corepressor interacting protein 2	0.5721	67
MSRB2	Methionine sulfoxide reductase B2	0.5701	67
TRIM6	Tripartite motif containing 6	0.5697	67
GNPDA1	Glucosamine-6-phosphate deaminase 1	0.5688	4
GGACT	Gamma-glutamylamine cyclotransferase	0.5633	67
PLEKHB2	Pleckstrin homology domain containing B2	0.5592	44
FBP1	Fructose-bisphosphatase 1	0.5581	67
ACOT4	Acyl-CoA thioesterase 4	0.5571	67
PEPD	Peptidase D	0.5568	67

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	16.6 nTPM
Adipose tissue	17.5 nTPM
Breast	15.7 nTPM

Alveolar cells type 1	25.6 nTPM
Lung	25.6 nTPM

Alveolar cells type 2	20.7 nTPM
Lung	20.7 nTPM

Astrocytes	20.5 nTPM
Brain	20.5 nTPM

B-cells	28.1 nTPM
Colon	52.7 nTPM
Kidney	38.1 nTPM
Stomach	34.5 nTPM
Spleen	33.2 nTPM
Liver	26.8 nTPM
Adipose tissue	25.5 nTPM
Lymph node	23.3 nTPM
PBMC	21.4 nTPM
Bone marrow	13.9 nTPM
Breast	12.1 nTPM

Dendritic cells	38.9 nTPM
PBMC	43.8 nTPM
Adipose tissue	41.6 nTPM
Breast	31.3 nTPM

Endothelial cells	24.1 nTPM
Pancreas	50.2 nTPM
Eye	49.3 nTPM
Skin	31.8 nTPM
Prostate	28.2 nTPM
Placenta	27.3 nTPM
Liver	23.8 nTPM
Esophagus	21.7 nTPM
Ovary	18.3 nTPM
Heart muscle	17.9 nTPM
Endometrium	15.2 nTPM
Skeletal muscle	14.5 nTPM
Breast	14.4 nTPM
Lung	12.5 nTPM
Testis	11.9 nTPM

Fibroblasts	38.8 nTPM
Skin	77.5 nTPM
Esophagus	64.2 nTPM
Stomach	46.0 nTPM
Adipose tissue	41.8 nTPM
Breast	34.1 nTPM
Prostate	34.0 nTPM
Skeletal muscle	28.0 nTPM
Heart muscle	27.0 nTPM
Ovary	27.0 nTPM
Placenta	25.1 nTPM
Lung	22.4 nTPM

Intestinal goblet cells	21.4 nTPM
Small intestine	28.4 nTPM
Rectum	22.4 nTPM
Colon	13.6 nTPM

Macrophages	167.6 nTPM
Pancreas	296.1 nTPM
Spleen	245.8 nTPM
Stomach	240.3 nTPM
Kidney	230.6 nTPM
Prostate	223.6 nTPM
Ovary	197.0 nTPM
Adipose tissue	186.9 nTPM
Bone marrow	184.9 nTPM
Testis	171.4 nTPM
Esophagus	138.5 nTPM
Skeletal muscle	111.0 nTPM
Breast	93.7 nTPM
Endometrium	85.5 nTPM
Lung	81.8 nTPM
PBMC	27.3 nTPM

Paneth cells	19.7 nTPM
Small intestine	30.0 nTPM
Rectum	22.6 nTPM
Colon	6.5 nTPM

Plasma cells	20.7 nTPM
Bone marrow	24.7 nTPM
Spleen	24.5 nTPM
Adipose tissue	22.5 nTPM
Esophagus	18.4 nTPM
Stomach	13.5 nTPM

Respiratory ciliated cells	18.0 nTPM
Bronchus	22.8 nTPM
Lung	13.1 nTPM

Smooth muscle cells	34.2 nTPM
Pancreas	52.4 nTPM
Skin	47.4 nTPM
Heart muscle	41.4 nTPM
Prostate	40.0 nTPM
Esophagus	34.1 nTPM
Ovary	29.5 nTPM
Bronchus	29.1 nTPM
Adipose tissue	28.4 nTPM
Skeletal muscle	28.2 nTPM
Breast	22.7 nTPM
Endometrium	22.5 nTPM

T-cells	27.1 nTPM
Adipose tissue	45.4 nTPM
Kidney	43.1 nTPM
Skin	34.0 nTPM
Stomach	31.5 nTPM
Colon	31.4 nTPM
Ovary	31.1 nTPM
Spleen	29.5 nTPM
Lymph node	28.9 nTPM
Prostate	23.6 nTPM
Liver	22.8 nTPM
Lung	22.8 nTPM
Breast	22.8 nTPM
Skeletal muscle	21.9 nTPM
Bone marrow	21.6 nTPM
PBMC	20.8 nTPM
Endometrium	16.2 nTPM
Esophagus	13.1 nTPM

Basal keratinocytes	58.0 nTPM
Skin	58.0 nTPM

Basal respiratory cells	52.1 nTPM
Bronchus	52.1 nTPM

Basal squamous epithelial cells	33.0 nTPM
Esophagus	33.0 nTPM

Cholangiocytes	25.8 nTPM
Liver	25.8 nTPM

Undifferentiated cells	24.7 nTPM
Small intestine	36.1 nTPM
Rectum	20.8 nTPM
Colon	17.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC