Single cell type - MTDH - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MTDH
Gene descriptionⁱ Full gene name according to HGNC.	Metadherin
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Plasma cells - Humoral immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MTDH is part of cluster 55 Plasma cells - Humoral immune response with confidenceⁱ 1
379 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
DERL1	Derlin 1	0.6788	55
SUB1	SUB1 regulator of transcription	0.6706	55
IGHV3-64	Immunoglobulin heavy variable 3-64	0.6384	55
IGHJ1	Immunoglobulin heavy joining 1	0.6343	55
IGHG2	Immunoglobulin heavy constant gamma 2 (G2m marker)	0.6339	55
OR2D3	Olfactory receptor family 2 subfamily D member 3	0.6305	55
IGKV6D-21	Immunoglobulin kappa variable 6D-21 (non-functional)	0.6292	55
IGLV7-43	Immunoglobulin lambda variable 7-43	0.6269	55
SSR3	Signal sequence receptor subunit 3	0.6253	55
IGLV10-54	Immunoglobulin lambda variable 10-54	0.6250	55
IGHG1	Immunoglobulin heavy constant gamma 1 (G1m marker)	0.6217	55
IGKV1D-16	Immunoglobulin kappa variable 1D-16	0.6203	55
IGHV3-53	Immunoglobulin heavy variable 3-53	0.6193	55
IGLV4-3	Immunoglobulin lambda variable 4-3	0.6168	55
IGHV3-35	Immunoglobulin heavy variable 3-35 (non-functional)	0.6168	55

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	185.1 nTPM
Adipose tissue	210.9 nTPM
Breast	159.3 nTPM

Alveolar cells type 1	128.2 nTPM
Lung	128.2 nTPM

Alveolar cells type 2	109.2 nTPM
Lung	109.2 nTPM

Astrocytes	69.2 nTPM
Brain	69.2 nTPM

B-cells	294.6 nTPM
Liver	953.0 nTPM
Breast	264.7 nTPM
Stomach	250.7 nTPM
Spleen	239.9 nTPM
Adipose tissue	238.1 nTPM
Lymph node	227.4 nTPM
Colon	225.3 nTPM
Kidney	195.2 nTPM
PBMC	181.3 nTPM
Bone marrow	170.8 nTPM

Basal squamous epithelial cells	194.1 nTPM
Esophagus	194.1 nTPM

Dendritic cells	231.7 nTPM
PBMC	330.7 nTPM
Adipose tissue	233.3 nTPM
Breast	131.2 nTPM

Endothelial cells	185.1 nTPM
Prostate	346.3 nTPM
Ovary	267.7 nTPM
Testis	237.6 nTPM
Esophagus	235.7 nTPM
Pancreas	220.0 nTPM
Breast	208.3 nTPM
Endometrium	200.4 nTPM
Skin	174.8 nTPM
Skeletal muscle	170.8 nTPM
Liver	166.0 nTPM
Placenta	160.3 nTPM
Lung	102.9 nTPM
Heart muscle	100.4 nTPM
Eye	0.0 nTPM

Enteroendocrine cells	121.8 nTPM
Colon	163.4 nTPM
Rectum	80.1 nTPM

Erythroid cells	205.7 nTPM
Bone marrow	229.5 nTPM
Liver	181.9 nTPM

Fibroblasts	227.2 nTPM
Prostate	470.5 nTPM
Adipose tissue	298.1 nTPM
Skin	239.9 nTPM
Esophagus	233.7 nTPM
Skeletal muscle	219.1 nTPM
Ovary	205.7 nTPM
Breast	187.4 nTPM
Lung	165.3 nTPM
Stomach	161.9 nTPM
Heart muscle	159.1 nTPM
Placenta	158.2 nTPM

Intestinal goblet cells	249.9 nTPM
Colon	422.4 nTPM
Small intestine	177.1 nTPM
Rectum	150.2 nTPM

Macrophages	266.5 nTPM
Testis	392.7 nTPM
Prostate	361.1 nTPM
Adipose tissue	354.0 nTPM
Esophagus	302.1 nTPM
Kidney	298.0 nTPM
Ovary	285.4 nTPM
Pancreas	275.6 nTPM
Stomach	272.5 nTPM
Spleen	260.2 nTPM
Endometrium	252.5 nTPM
Skeletal muscle	248.6 nTPM
Bone marrow	217.4 nTPM
Breast	193.6 nTPM
Lung	175.1 nTPM
PBMC	109.1 nTPM

Paneth cells	137.8 nTPM
Rectum	189.3 nTPM
Small intestine	135.2 nTPM
Colon	88.9 nTPM

Plasma cells	675.9 nTPM
Spleen	1176.5 nTPM
Bone marrow	949.2 nTPM
Stomach	629.4 nTPM
Esophagus	431.0 nTPM
Adipose tissue	193.6 nTPM

Cholangiocytes	201.6 nTPM
Liver	201.6 nTPM

Collecting duct cells	141.6 nTPM
Kidney	141.6 nTPM

Cytotrophoblasts	10.0 nTPM
Placenta	10.0 nTPM

Distal enterocytes	140.5 nTPM
Colon	170.7 nTPM
Rectum	110.3 nTPM

Respiratory ciliated cells	87.2 nTPM
Bronchus	117.5 nTPM
Lung	56.9 nTPM

Smooth muscle cells	334.5 nTPM
Bronchus	1394.4 nTPM
Pancreas	378.8 nTPM
Prostate	298.5 nTPM
Skeletal muscle	228.5 nTPM
Heart muscle	224.6 nTPM
Adipose tissue	218.8 nTPM
Ovary	210.2 nTPM
Esophagus	201.6 nTPM
Skin	191.1 nTPM
Endometrium	185.9 nTPM
Breast	146.6 nTPM

T-cells	200.3 nTPM
Prostate	279.3 nTPM
Adipose tissue	277.3 nTPM
Colon	253.7 nTPM
Skeletal muscle	242.3 nTPM
Lymph node	223.6 nTPM
Stomach	218.8 nTPM
PBMC	218.2 nTPM
Skin	209.1 nTPM
Spleen	200.9 nTPM
Liver	193.4 nTPM
Esophagus	190.0 nTPM
Endometrium	184.2 nTPM
Bone marrow	173.0 nTPM
Kidney	164.3 nTPM
Breast	149.6 nTPM
Ovary	137.9 nTPM
Lung	89.6 nTPM

Undifferentiated cells	251.6 nTPM
Colon	366.5 nTPM
Small intestine	209.0 nTPM
Rectum	179.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC