Single cell type - DERL1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DERL1
Gene descriptionⁱ Full gene name according to HGNC.	Derlin 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Plasma cells - Humoral immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Plasma cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (SK-BR-3)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Plasma cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

DERL1 is part of cluster 55 Plasma cells - Humoral immune response with confidenceⁱ 0.93
379 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MTDH	Metadherin	0.6788	55
SLC35B1	Solute carrier family 35 member B1	0.6745	55
MANF	Mesencephalic astrocyte derived neurotrophic factor	0.6368	55
FKBP11	FKBP prolyl isomerase 11	0.6318	55
SUB1	SUB1 regulator of transcription	0.6203	55
DNAJC3	DnaJ heat shock protein family (Hsp40) member C3	0.6103	55
AUP1	AUP1 lipid droplet regulating VLDL assembly factor	0.6092	55
RPL22L1	Ribosomal protein L22 like 1	0.5990	10
ERLEC1	Endoplasmic reticulum lectin 1	0.5963	55
SPCS3	Signal peptidase complex subunit 3	0.5905	55
TMEM33	Transmembrane protein 33	0.5574	10
LRRC59	Leucine rich repeat containing 59	0.5550	55
CD38	CD38 molecule	0.5453	55
IGHV1-24	Immunoglobulin heavy variable 1-24	0.5330	55
TXNDC5	Thioredoxin domain containing 5	0.5323	55

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	38.6 nTPM
Adipose tissue	43.7 nTPM
Breast	33.4 nTPM

Alveolar cells type 1	32.1 nTPM
Lung	32.1 nTPM

Alveolar cells type 2	25.9 nTPM
Lung	25.9 nTPM

Astrocytes	12.4 nTPM
Brain	12.4 nTPM

B-cells	78.3 nTPM
Liver	238.9 nTPM
Breast	93.5 nTPM
Stomach	79.1 nTPM
Lymph node	65.3 nTPM
Spleen	60.9 nTPM
Adipose tissue	58.1 nTPM
Colon	57.5 nTPM
Bone marrow	48.3 nTPM
Kidney	42.9 nTPM
PBMC	38.6 nTPM

Dendritic cells	67.6 nTPM
Adipose tissue	92.8 nTPM
Breast	82.0 nTPM
PBMC	27.9 nTPM

Endothelial cells	39.2 nTPM
Prostate	68.4 nTPM
Liver	61.4 nTPM
Pancreas	57.9 nTPM
Ovary	39.5 nTPM
Placenta	38.0 nTPM
Heart muscle	36.5 nTPM
Esophagus	34.6 nTPM
Skeletal muscle	34.3 nTPM
Breast	32.9 nTPM
Endometrium	32.2 nTPM
Skin	32.1 nTPM
Testis	30.8 nTPM
Lung	28.1 nTPM
Eye	21.8 nTPM

Fibroblasts	43.8 nTPM
Prostate	66.7 nTPM
Stomach	65.3 nTPM
Adipose tissue	55.1 nTPM
Skin	44.9 nTPM
Esophagus	42.7 nTPM
Placenta	42.4 nTPM
Heart muscle	39.5 nTPM
Skeletal muscle	37.1 nTPM
Breast	34.3 nTPM
Ovary	28.5 nTPM
Lung	25.7 nTPM

Intestinal goblet cells	62.2 nTPM
Colon	89.4 nTPM
Rectum	55.9 nTPM
Small intestine	41.5 nTPM

Macrophages	45.6 nTPM
Pancreas	84.2 nTPM
Ovary	58.3 nTPM
Prostate	56.1 nTPM
Lung	53.5 nTPM
Spleen	51.8 nTPM
Adipose tissue	51.3 nTPM
Kidney	47.6 nTPM
Breast	45.0 nTPM
Testis	44.1 nTPM
Stomach	43.9 nTPM
Endometrium	42.7 nTPM
Skeletal muscle	37.9 nTPM
Bone marrow	33.8 nTPM
Esophagus	33.1 nTPM
PBMC	0.0 nTPM

Paneth cells	40.6 nTPM
Small intestine	48.8 nTPM
Rectum	46.5 nTPM
Colon	26.4 nTPM

Plasma cells	225.0 nTPM
Spleen	355.6 nTPM
Stomach	260.4 nTPM
Bone marrow	230.7 nTPM
Esophagus	184.8 nTPM
Adipose tissue	93.5 nTPM

Respiratory ciliated cells	31.3 nTPM
Bronchus	50.9 nTPM
Lung	11.7 nTPM

Smooth muscle cells	77.6 nTPM
Bronchus	479.8 nTPM
Pancreas	101.5 nTPM
Prostate	46.9 nTPM
Adipose tissue	36.0 nTPM
Ovary	33.9 nTPM
Heart muscle	33.7 nTPM
Skin	32.1 nTPM
Skeletal muscle	26.5 nTPM
Endometrium	22.3 nTPM
Breast	20.7 nTPM
Esophagus	20.1 nTPM

T-cells	69.8 nTPM
Prostate	104.2 nTPM
Ovary	95.6 nTPM
Stomach	91.4 nTPM
Colon	90.3 nTPM
Adipose tissue	84.7 nTPM
Spleen	81.5 nTPM
Kidney	70.5 nTPM
Skeletal muscle	66.1 nTPM
Esophagus	65.5 nTPM
Breast	65.1 nTPM
Liver	63.0 nTPM
Endometrium	61.5 nTPM
Lymph node	61.3 nTPM
Bone marrow	60.5 nTPM
Skin	53.9 nTPM
PBMC	39.8 nTPM
Lung	31.9 nTPM

Basal keratinocytes	42.3 nTPM
Skin	42.3 nTPM

Basal prostatic cells	41.8 nTPM
Prostate	41.8 nTPM

Basal respiratory cells	57.3 nTPM
Bronchus	57.3 nTPM

Basal squamous epithelial cells	26.7 nTPM
Esophagus	26.7 nTPM

Undifferentiated cells	37.5 nTPM
Colon	45.5 nTPM
Rectum	35.7 nTPM
Small intestine	31.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC