Single cell type - CBWD5 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CBWD5
Gene descriptionⁱ Full gene name according to HGNC.	COBW domain containing 5
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Basal squamous epithelial cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Basal squamous epithelial cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CBWD5 is part of cluster 59 Non-specific - Transcription with confidenceⁱ 1
354 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CBWD2	COBW domain containing 2	0.6788	28
CBWD1	COBW domain containing 1	0.5940	59
RAB24	RAB24, member RAS oncogene family	0.5721	59
ATP6V0C	ATPase H+ transporting V0 subunit c	0.5714	59
ZNF749	Zinc finger protein 749	0.5598	61
BCKDHA	Branched chain keto acid dehydrogenase E1 subunit alpha	0.5557	59
GTF2H4	General transcription factor IIH subunit 4	0.5534	59
TRAPPC5	Trafficking protein particle complex 5	0.5511	59
MRPS24	Mitochondrial ribosomal protein S24	0.5498	59
ALG9	ALG9 alpha-1,2-mannosyltransferase	0.5491	59
PAM16	Presequence translocase associated motor 16	0.5482	59
NME2	NME/NM23 nucleoside diphosphate kinase 2	0.5430	61
MRPL38	Mitochondrial ribosomal protein L38	0.5400	59
EEF1G	Eukaryotic translation elongation factor 1 gamma	0.5333	59
PDF	Peptide deformylase, mitochondrial	0.5282	59

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	17.8 nTPM
Adipose tissue	21.6 nTPM
Breast	14.1 nTPM

Alveolar cells type 1	41.7 nTPM
Lung	41.7 nTPM

Alveolar cells type 2	51.8 nTPM
Lung	51.8 nTPM

Astrocytes	13.4 nTPM
Brain	13.4 nTPM

B-cells	58.4 nTPM
Lymph node	92.9 nTPM
Stomach	87.7 nTPM
Bone marrow	76.0 nTPM
Spleen	64.0 nTPM
Liver	54.9 nTPM
Kidney	52.4 nTPM
Colon	51.1 nTPM
Breast	41.5 nTPM
Adipose tissue	32.1 nTPM
PBMC	31.5 nTPM

Basal squamous epithelial cells	178.7 nTPM
Esophagus	178.7 nTPM

Dendritic cells	10.6 nTPM
Breast	12.4 nTPM
Adipose tissue	11.3 nTPM
PBMC	8.0 nTPM

Endothelial cells	22.8 nTPM
Esophagus	53.2 nTPM
Pancreas	38.6 nTPM
Testis	32.3 nTPM
Heart muscle	31.0 nTPM
Skin	23.0 nTPM
Breast	22.9 nTPM
Lung	18.7 nTPM
Ovary	17.3 nTPM
Eye	17.0 nTPM
Skeletal muscle	16.2 nTPM
Liver	13.7 nTPM
Placenta	13.1 nTPM
Prostate	12.4 nTPM
Endometrium	10.2 nTPM

Fibroblasts	20.1 nTPM
Stomach	40.1 nTPM
Heart muscle	34.5 nTPM
Lung	30.1 nTPM
Esophagus	26.4 nTPM
Prostate	22.5 nTPM
Breast	15.2 nTPM
Placenta	13.7 nTPM
Skin	12.5 nTPM
Ovary	10.9 nTPM
Adipose tissue	8.5 nTPM
Skeletal muscle	6.5 nTPM

Intestinal goblet cells	32.6 nTPM
Colon	39.3 nTPM
Small intestine	35.4 nTPM
Rectum	23.1 nTPM

Macrophages	27.5 nTPM
Stomach	58.6 nTPM
Esophagus	58.3 nTPM
Bone marrow	53.7 nTPM
Spleen	42.5 nTPM
Kidney	33.3 nTPM
Lung	32.6 nTPM
Testis	28.4 nTPM
Pancreas	23.0 nTPM
Endometrium	22.9 nTPM
Breast	18.7 nTPM
Adipose tissue	12.6 nTPM
Skeletal muscle	11.9 nTPM
Prostate	9.1 nTPM
Ovary	6.8 nTPM
PBMC	0.0 nTPM

Paneth cells	51.1 nTPM
Colon	69.2 nTPM
Small intestine	48.8 nTPM
Rectum	35.2 nTPM

Plasma cells	143.5 nTPM
Spleen	222.4 nTPM
Stomach	171.1 nTPM
Esophagus	154.1 nTPM
Bone marrow	153.3 nTPM
Adipose tissue	16.7 nTPM

Respiratory ciliated cells	27.8 nTPM
Lung	39.4 nTPM
Bronchus	16.3 nTPM

Smooth muscle cells	18.8 nTPM
Esophagus	35.7 nTPM
Heart muscle	33.9 nTPM
Pancreas	31.0 nTPM
Skin	22.6 nTPM
Adipose tissue	17.9 nTPM
Skeletal muscle	15.1 nTPM
Breast	14.1 nTPM
Ovary	12.8 nTPM
Prostate	10.6 nTPM
Endometrium	9.8 nTPM
Bronchus	2.9 nTPM

Cholangiocytes	25.8 nTPM
Liver	25.8 nTPM

Collecting duct cells	20.2 nTPM
Kidney	20.2 nTPM

Cone photoreceptor cells	68.8 nTPM
Eye	68.8 nTPM

Cytotrophoblasts	44.0 nTPM
Placenta	44.0 nTPM

T-cells	29.6 nTPM
Lymph node	68.8 nTPM
Bone marrow	46.2 nTPM
Esophagus	45.9 nTPM
Stomach	45.9 nTPM
Spleen	43.2 nTPM
Lung	34.9 nTPM
Skin	25.4 nTPM
Liver	24.5 nTPM
PBMC	22.9 nTPM
Breast	22.3 nTPM
Kidney	21.2 nTPM
Colon	20.5 nTPM
Adipose tissue	20.2 nTPM
Prostate	19.0 nTPM
Skeletal muscle	16.9 nTPM
Endometrium	14.4 nTPM
Ovary	11.1 nTPM

Undifferentiated cells	34.2 nTPM
Small intestine	38.3 nTPM
Colon	36.7 nTPM
Rectum	27.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC