Single cell type - ST14 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ST14
Gene descriptionⁱ Full gene name according to HGNC.	ST14 transmembrane serine protease matriptase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Enzymes Human disease related genes Plasma proteins Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Intestinal epithelial cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Distal enterocytes, Paneth cells, Urothelial cells, Proximal enterocytes, Undifferentiated cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enriched (plasmacytoid DC)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (CACO-2, CAPAN-2, HaCaT, OE19, RPMI-8226, SK-BR-3, T-47d, U-698)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Distal enterocytes, Paneth cells, Urothelial cells, Proximal enterocytes, Undifferentiated cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ST14 is part of cluster 53 Intestinal epithelial cells - Unknown function with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PLCD3	Phospholipase C delta 3	0.8073	53
CEACAM1	CEA cell adhesion molecule 1	0.7771	53
MUC12	Mucin 12, cell surface associated	0.7636	53
TMEM54	Transmembrane protein 54	0.7567	53
TRIM31	Tripartite motif containing 31	0.7506	53
TMPRSS2	Transmembrane serine protease 2	0.7381	53
CLCA4	Chloride channel accessory 4	0.7307	53
GIPC1	GIPC PDZ domain containing family member 1	0.7230	53
ETHE1	ETHE1 persulfide dioxygenase	0.7229	53
MYH14	Myosin heavy chain 14	0.7174	53
OAS1	2'-5'-oligoadenylate synthetase 1	0.7138	53
GCNT3	Glucosaminyl (N-acetyl) transferase 3, mucin type	0.7060	53
PLCD1	Phospholipase C delta 1	0.7056	53
ARL14	ADP ribosylation factor like GTPase 14	0.7038	53
GGT6	Gamma-glutamyltransferase 6	0.6943	53

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	0.2 nTPM
Breast	0.4 nTPM
Adipose tissue	0.0 nTPM

Alveolar cells type 1	32.1 nTPM
Lung	32.1 nTPM

Alveolar cells type 2	28.6 nTPM
Lung	28.6 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	18.2 nTPM
Colon	33.5 nTPM
Stomach	31.4 nTPM
Bone marrow	27.8 nTPM
Adipose tissue	20.6 nTPM
Lymph node	18.7 nTPM
Spleen	17.6 nTPM
PBMC	15.7 nTPM
Breast	9.4 nTPM
Kidney	4.8 nTPM
Liver	2.8 nTPM

Dendritic cells	26.1 nTPM
PBMC	75.7 nTPM
Breast	1.5 nTPM
Adipose tissue	1.2 nTPM

Endothelial cells	1.7 nTPM
Prostate	6.7 nTPM
Breast	5.8 nTPM
Skin	3.8 nTPM
Lung	3.1 nTPM
Endometrium	2.3 nTPM
Placenta	0.6 nTPM
Esophagus	0.6 nTPM
Heart muscle	0.3 nTPM
Testis	0.3 nTPM
Ovary	0.3 nTPM
Skeletal muscle	0.1 nTPM
Eye	0.0 nTPM
Liver	0.0 nTPM
Pancreas	0.0 nTPM

Enteroendocrine cells	123.4 nTPM
Colon	127.9 nTPM
Rectum	118.9 nTPM

Fibroblasts	3.2 nTPM
Lung	13.4 nTPM
Prostate	6.2 nTPM
Placenta	3.5 nTPM
Skin	3.0 nTPM
Stomach	3.0 nTPM
Heart muscle	2.8 nTPM
Breast	1.9 nTPM
Esophagus	1.0 nTPM
Skeletal muscle	0.1 nTPM
Adipose tissue	0.1 nTPM
Ovary	0.0 nTPM

Intestinal goblet cells	201.0 nTPM
Colon	274.4 nTPM
Rectum	174.4 nTPM
Small intestine	154.1 nTPM

Macrophages	28.0 nTPM
Pancreas	76.5 nTPM
Prostate	63.0 nTPM
Esophagus	44.1 nTPM
Testis	27.8 nTPM
Adipose tissue	27.0 nTPM
Ovary	25.7 nTPM
Lung	22.3 nTPM
Endometrium	21.5 nTPM
Bone marrow	21.2 nTPM
Breast	21.1 nTPM
Stomach	20.5 nTPM
Skeletal muscle	19.0 nTPM
Spleen	16.5 nTPM
Kidney	13.7 nTPM
PBMC	0.0 nTPM

Paneth cells	327.2 nTPM
Colon	645.5 nTPM
Rectum	197.3 nTPM
Small intestine	138.9 nTPM

Plasma cells	5.9 nTPM
Bone marrow	11.5 nTPM
Adipose tissue	9.1 nTPM
Spleen	6.7 nTPM
Stomach	2.0 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	76.4 nTPM
Bronchus	133.9 nTPM
Lung	19.0 nTPM

Smooth muscle cells	4.9 nTPM
Bronchus	35.5 nTPM
Prostate	6.5 nTPM
Pancreas	5.5 nTPM
Endometrium	2.5 nTPM
Breast	1.7 nTPM
Skin	1.1 nTPM
Heart muscle	0.6 nTPM
Ovary	0.1 nTPM
Skeletal muscle	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM

Basal keratinocytes	40.9 nTPM
Skin	40.9 nTPM

Basal prostatic cells	51.5 nTPM
Prostate	51.5 nTPM

Basal respiratory cells	45.2 nTPM
Bronchus	45.2 nTPM

Cholangiocytes	77.2 nTPM
Liver	77.2 nTPM

T-cells	2.9 nTPM
Esophagus	13.1 nTPM
Colon	10.9 nTPM
Endometrium	7.4 nTPM
Prostate	4.7 nTPM
Lung	4.5 nTPM
Kidney	3.4 nTPM
Breast	2.2 nTPM
Skin	1.4 nTPM
Stomach	0.6 nTPM
Skeletal muscle	0.5 nTPM
PBMC	0.4 nTPM
Lymph node	0.3 nTPM
Spleen	0.3 nTPM
Adipose tissue	0.1 nTPM
Liver	0.0 nTPM
Ovary	0.0 nTPM
Bone marrow	0.0 nTPM

Undifferentiated cells	216.9 nTPM
Colon	296.9 nTPM
Rectum	195.2 nTPM
Small intestine	158.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC