Single cell type - NUDT22 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NUDT22
Gene descriptionⁱ Full gene name according to HGNC.	Nudix hydrolase 22
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Distal tubular cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Distal tubular cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

NUDT22 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 1
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
HINT2	Histidine triad nucleotide binding protein 2	0.5352	39
NDUFS2	NADH:ubiquinone oxidoreductase core subunit S2	0.5330	10
NDUFS3	NADH:ubiquinone oxidoreductase core subunit S3	0.5302	39
CLYBL	Citramalyl-CoA lyase	0.5169	67
MRPL2	Mitochondrial ribosomal protein L2	0.5025	10
PSMB1	Proteasome 20S subunit beta 1	0.5023	10
FBXL15	F-box and leucine rich repeat protein 15	0.4908	39
ADH5	Alcohol dehydrogenase 5 (class III), chi polypeptide	0.4849	39
PPCS	Phosphopantothenoylcysteine synthetase	0.4755	39
FAM162A	Family with sequence similarity 162 member A	0.4692	10
SLC25A5	Solute carrier family 25 member 5	0.4596	45
DNAJC17	DnaJ heat shock protein family (Hsp40) member C17	0.4552	26
MRPL27	Mitochondrial ribosomal protein L27	0.4516	39
CYC1	Cytochrome c1	0.4489	39
SLC2A9	Solute carrier family 2 member 9	0.4418	67

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	18.8 nTPM
Breast	28.1 nTPM
Adipose tissue	9.6 nTPM

Alveolar cells type 1	3.2 nTPM
Lung	3.2 nTPM

Alveolar cells type 2	14.6 nTPM
Lung	14.6 nTPM

Astrocytes	5.5 nTPM
Brain	5.5 nTPM

B-cells	42.6 nTPM
Liver	94.3 nTPM
Breast	60.2 nTPM
PBMC	54.3 nTPM
Bone marrow	41.7 nTPM
Spleen	35.3 nTPM
Stomach	34.5 nTPM
Lymph node	34.3 nTPM
Kidney	28.5 nTPM
Colon	27.1 nTPM
Adipose tissue	15.6 nTPM

Dendritic cells	51.5 nTPM
PBMC	79.7 nTPM
Breast	48.8 nTPM
Adipose tissue	25.9 nTPM

Endothelial cells	20.3 nTPM
Placenta	33.5 nTPM
Liver	32.1 nTPM
Pancreas	27.0 nTPM
Breast	25.4 nTPM
Testis	24.6 nTPM
Ovary	23.3 nTPM
Eye	21.8 nTPM
Prostate	20.5 nTPM
Endometrium	19.4 nTPM
Esophagus	16.4 nTPM
Skin	14.9 nTPM
Skeletal muscle	13.5 nTPM
Lung	9.3 nTPM
Heart muscle	1.7 nTPM

Fibroblasts	20.1 nTPM
Ovary	31.7 nTPM
Prostate	29.2 nTPM
Placenta	29.0 nTPM
Breast	27.2 nTPM
Skin	22.6 nTPM
Esophagus	22.2 nTPM
Skeletal muscle	19.1 nTPM
Adipose tissue	18.0 nTPM
Stomach	10.4 nTPM
Lung	7.8 nTPM
Heart muscle	4.3 nTPM

Intestinal goblet cells	98.1 nTPM
Colon	148.7 nTPM
Small intestine	74.6 nTPM
Rectum	70.9 nTPM

Macrophages	40.0 nTPM
Kidney	72.5 nTPM
Pancreas	61.2 nTPM
Bone marrow	53.7 nTPM
Prostate	51.6 nTPM
Testis	47.0 nTPM
Ovary	42.8 nTPM
Breast	41.8 nTPM
Endometrium	39.0 nTPM
Skeletal muscle	33.6 nTPM
Spleen	33.2 nTPM
Esophagus	31.5 nTPM
Stomach	29.4 nTPM
Lung	26.1 nTPM
Adipose tissue	22.3 nTPM
PBMC	13.6 nTPM

Paneth cells	93.0 nTPM
Small intestine	108.8 nTPM
Colon	105.4 nTPM
Rectum	64.8 nTPM

Plasma cells	65.8 nTPM
Stomach	99.6 nTPM
Spleen	78.7 nTPM
Esophagus	67.8 nTPM
Bone marrow	59.4 nTPM
Adipose tissue	23.3 nTPM

Respiratory ciliated cells	13.6 nTPM
Bronchus	22.8 nTPM
Lung	4.4 nTPM

Smooth muscle cells	45.0 nTPM
Bronchus	233.9 nTPM
Pancreas	62.7 nTPM
Breast	34.1 nTPM
Esophagus	29.4 nTPM
Ovary	28.7 nTPM
Prostate	26.3 nTPM
Skeletal muscle	22.4 nTPM
Endometrium	21.2 nTPM
Adipose tissue	15.2 nTPM
Skin	15.0 nTPM
Heart muscle	5.5 nTPM

T-cells	37.5 nTPM
Ovary	86.7 nTPM
Kidney	54.0 nTPM
Liver	50.0 nTPM
PBMC	43.7 nTPM
Bone marrow	43.6 nTPM
Stomach	43.1 nTPM
Prostate	42.6 nTPM
Lung	38.0 nTPM
Spleen	34.9 nTPM
Breast	34.2 nTPM
Colon	30.9 nTPM
Skin	29.0 nTPM
Lymph node	27.5 nTPM
Endometrium	23.9 nTPM
Skeletal muscle	22.4 nTPM
Esophagus	19.7 nTPM
Adipose tissue	13.9 nTPM

Basal keratinocytes	12.0 nTPM
Skin	12.0 nTPM

Basal prostatic cells	28.9 nTPM
Prostate	28.9 nTPM

Basal respiratory cells	78.8 nTPM
Bronchus	78.8 nTPM

Cholangiocytes	48.6 nTPM
Liver	48.6 nTPM

Undifferentiated cells	73.6 nTPM
Colon	81.7 nTPM
Rectum	77.7 nTPM
Small intestine	61.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC