Single cell type - NDUFS2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NDUFS2
Gene descriptionⁱ Full gene name according to HGNC.	NADH:ubiquinone oxidoreductase core subunit S2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	15

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

NDUFS2 is part of cluster 10 Non-specific - Unknown function with confidenceⁱ 1
482 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NDUFS3	NADH:ubiquinone oxidoreductase core subunit S3	0.6990	39
FAM162A	Family with sequence similarity 162 member A	0.6919	10
MRPL35	Mitochondrial ribosomal protein L35	0.6616	39
AK2	Adenylate kinase 2	0.6541	67
NDUFV1	NADH:ubiquinone oxidoreductase core subunit V1	0.6414	39
PSMC6	Proteasome 26S subunit, ATPase 6	0.6281	10
MRPL27	Mitochondrial ribosomal protein L27	0.6265	39
MRPL2	Mitochondrial ribosomal protein L2	0.6224	10
SDHB	Succinate dehydrogenase complex iron sulfur subunit B	0.6170	39
PSMB5	Proteasome 20S subunit beta 5	0.6053	10
NDUFS4	NADH:ubiquinone oxidoreductase subunit S4	0.6037	39
CLYBL	Citramalyl-CoA lyase	0.5928	67
TBC1D7	TBC1 domain family member 7	0.5878	10
NDUFB9	NADH:ubiquinone oxidoreductase subunit B9	0.5796	10
ENY2	ENY2 transcription and export complex 2 subunit	0.5732	10

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	70.5 nTPM
Breast	73.3 nTPM
Adipose tissue	67.6 nTPM

Alveolar cells type 1	35.3 nTPM
Lung	35.3 nTPM

Alveolar cells type 2	45.7 nTPM
Lung	45.7 nTPM

Astrocytes	30.7 nTPM
Brain	30.7 nTPM

B-cells	47.1 nTPM
Liver	108.6 nTPM
Kidney	66.6 nTPM
Breast	52.2 nTPM
Colon	46.4 nTPM
Bone marrow	42.5 nTPM
Spleen	39.8 nTPM
PBMC	37.1 nTPM
Lymph node	33.4 nTPM
Stomach	27.3 nTPM
Adipose tissue	17.1 nTPM

Dendritic cells	47.6 nTPM
Breast	68.1 nTPM
PBMC	39.8 nTPM
Adipose tissue	34.8 nTPM

Endothelial cells	67.5 nTPM
Pancreas	115.9 nTPM
Placenta	88.1 nTPM
Ovary	81.8 nTPM
Liver	72.4 nTPM
Eye	71.2 nTPM
Lung	65.5 nTPM
Esophagus	64.4 nTPM
Heart muscle	63.6 nTPM
Prostate	58.7 nTPM
Skeletal muscle	58.6 nTPM
Skin	57.1 nTPM
Endometrium	51.0 nTPM
Breast	50.1 nTPM
Testis	46.8 nTPM

Fibroblasts	69.7 nTPM
Ovary	100.5 nTPM
Prostate	90.5 nTPM
Heart muscle	89.1 nTPM
Stomach	89.1 nTPM
Esophagus	88.3 nTPM
Placenta	86.8 nTPM
Breast	59.3 nTPM
Adipose tissue	48.3 nTPM
Lung	47.0 nTPM
Skin	35.4 nTPM
Skeletal muscle	32.7 nTPM

Intestinal goblet cells	122.6 nTPM
Colon	163.0 nTPM
Rectum	108.3 nTPM
Small intestine	96.6 nTPM

Macrophages	66.5 nTPM
Pancreas	130.2 nTPM
Ovary	105.4 nTPM
Kidney	96.8 nTPM
Breast	87.8 nTPM
Bone marrow	76.2 nTPM
Testis	73.2 nTPM
Lung	70.2 nTPM
Stomach	61.5 nTPM
Spleen	61.1 nTPM
Prostate	57.3 nTPM
Adipose tissue	56.8 nTPM
Skeletal muscle	46.3 nTPM
Endometrium	42.7 nTPM
Esophagus	31.5 nTPM
PBMC	0.0 nTPM

Paneth cells	105.1 nTPM
Rectum	119.3 nTPM
Colon	102.1 nTPM
Small intestine	93.9 nTPM

Plasma cells	49.5 nTPM
Bone marrow	84.1 nTPM
Spleen	65.6 nTPM
Stomach	49.7 nTPM
Adipose tissue	29.7 nTPM
Esophagus	18.4 nTPM

Respiratory ciliated cells	103.0 nTPM
Bronchus	131.7 nTPM
Lung	74.4 nTPM

Smooth muscle cells	176.6 nTPM
Bronchus	800.1 nTPM
Prostate	271.6 nTPM
Pancreas	159.5 nTPM
Ovary	129.3 nTPM
Skeletal muscle	125.0 nTPM
Esophagus	117.8 nTPM
Breast	88.0 nTPM
Skin	67.2 nTPM
Adipose tissue	63.6 nTPM
Heart muscle	60.5 nTPM
Endometrium	60.3 nTPM

T-cells	50.0 nTPM
Ovary	102.3 nTPM
Kidney	90.3 nTPM
Liver	70.5 nTPM
Bone marrow	53.0 nTPM
Breast	52.3 nTPM
Lung	50.1 nTPM
Prostate	47.3 nTPM
Stomach	47.3 nTPM
Esophagus	45.9 nTPM
Lymph node	41.6 nTPM
Colon	40.9 nTPM
Skin	40.9 nTPM
Spleen	39.4 nTPM
PBMC	38.4 nTPM
Adipose tissue	32.4 nTPM
Endometrium	29.8 nTPM
Skeletal muscle	27.6 nTPM

Basal keratinocytes	38.9 nTPM
Skin	38.9 nTPM

Basal prostatic cells	52.4 nTPM
Prostate	52.4 nTPM

Basal respiratory cells	277.8 nTPM
Bronchus	277.8 nTPM

Basal squamous epithelial cells	52.9 nTPM
Esophagus	52.9 nTPM

Undifferentiated cells	172.5 nTPM
Colon	235.8 nTPM
Rectum	141.7 nTPM
Small intestine	140.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC