Cell line - TIAL1 - The Human Protein Atlas

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TIAL1

SUMMARY

TISSUE

BRAIN

SINGLE CELL

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BLOOD

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METABOLIC

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TIAL1
Gene descriptionⁱ Full gene name according to HGNC.	TIA1 cytotoxic granule associated RNA binding protein like 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	RPE1 & U-87MG - Synaptic function (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

TIAL1 is part of cluster 11 RPE1 & U-87MG - Synaptic function with confidenceⁱ 1
308 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SEC31B	SEC31 homolog B, COPII coat complex component	0.6818	22
LRRC27	Leucine rich repeat containing 27	0.6808	23
PNISR	PNN interacting serine and arginine rich protein	0.6684	20
NICN1	Nicolin 1	0.6314	11
PCDHGB7	Protocadherin gamma subfamily B, 7	0.6243	23
BTAF1	B-TFIID TATA-box binding protein associated factor 1	0.6152	27
FRA10AC1	FRA10A associated CGG repeat 1	0.5994	26
MSS51	MSS51 mitochondrial translational activator	0.5911	34
SLC35E2B	Solute carrier family 35 member E2B	0.5889	11
ZDHHC6	Zinc finger DHHC-type palmitoyltransferase 6	0.5719	32
VAMP2	Vesicle associated membrane protein 2	0.5652	11
DHFR2	Dihydrofolate reductase 2	0.5648	11
RABL2B	RAB, member of RAS oncogene family like 2B	0.5634	11
CUEDC2	CUE domain containing 2	0.5593	11
SFRP1	Secreted frizzled related protein 1	0.5575	11

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.