Single cell type - CWF19L2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CWF19L2
Gene descriptionⁱ Full gene name according to HGNC.	CWF19 like cell cycle control factor 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CWF19L2 is part of cluster 52 Non-specific - Transcription with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NKTR	Natural killer cell triggering receptor	0.6051	52
NRDE2	NRDE-2, necessary for RNA interference, domain containing	0.6018	52
ZFP14	ZFP14 zinc finger protein	0.5970	52
MPHOSPH8	M-phase phosphoprotein 8	0.5904	52
N4BP2L2	NEDD4 binding protein 2 like 2	0.5485	52
MDM4	MDM4 regulator of p53	0.5450	52
CCDC66	Coiled-coil domain containing 66	0.5443	52
TNRC6B	Trinucleotide repeat containing adaptor 6B	0.5390	52
EZH1	Enhancer of zeste 1 polycomb repressive complex 2 subunit	0.5387	46
TRMT10B	TRNA methyltransferase 10B	0.5261	52
RSRC1	Arginine and serine rich coiled-coil 1	0.5160	39
ZRANB2	Zinc finger RANBP2-type containing 2	0.5146	52
KCTD7	Potassium channel tetramerization domain containing 7	0.5072	46
ZNHIT6	Zinc finger HIT-type containing 6	0.5067	52
RBM23	RNA binding motif protein 23	0.5036	52

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	56.2 nTPM
Adipose tissue	77.1 nTPM
Breast	35.4 nTPM

Alveolar cells type 1	38.5 nTPM
Lung	38.5 nTPM

Alveolar cells type 2	53.2 nTPM
Lung	53.2 nTPM

Astrocytes	38.5 nTPM
Brain	38.5 nTPM

B-cells	66.1 nTPM
Kidney	119.0 nTPM
Adipose tissue	115.3 nTPM
PBMC	91.3 nTPM
Liver	53.3 nTPM
Colon	51.1 nTPM
Stomach	49.9 nTPM
Breast	48.1 nTPM
Bone marrow	47.4 nTPM
Lymph node	44.0 nTPM
Spleen	41.2 nTPM

Dendritic cells	57.9 nTPM
Adipose tissue	91.2 nTPM
PBMC	43.8 nTPM
Breast	38.6 nTPM

Endothelial cells	40.8 nTPM
Liver	79.8 nTPM
Lung	71.7 nTPM
Heart muscle	67.4 nTPM
Testis	64.0 nTPM
Skeletal muscle	49.4 nTPM
Breast	47.4 nTPM
Eye	46.9 nTPM
Endometrium	31.2 nTPM
Skin	26.7 nTPM
Placenta	25.6 nTPM
Ovary	18.8 nTPM
Esophagus	17.9 nTPM
Pancreas	15.5 nTPM
Prostate	8.8 nTPM

Fibroblasts	29.3 nTPM
Adipose tissue	66.9 nTPM
Breast	52.2 nTPM
Heart muscle	40.1 nTPM
Skeletal muscle	34.6 nTPM
Lung	27.9 nTPM
Skin	24.3 nTPM
Placenta	20.4 nTPM
Esophagus	19.1 nTPM
Stomach	14.9 nTPM
Ovary	11.5 nTPM
Prostate	10.5 nTPM

Intestinal goblet cells	27.0 nTPM
Colon	32.9 nTPM
Small intestine	27.9 nTPM
Rectum	20.1 nTPM

Macrophages	24.5 nTPM
Testis	49.4 nTPM
Lung	44.6 nTPM
Adipose tissue	41.9 nTPM
Kidney	41.5 nTPM
Endometrium	38.2 nTPM
Breast	30.6 nTPM
Skeletal muscle	25.9 nTPM
Ovary	24.3 nTPM
Bone marrow	18.8 nTPM
Pancreas	17.8 nTPM
Spleen	13.5 nTPM
Esophagus	12.6 nTPM
Prostate	8.1 nTPM
PBMC	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	31.6 nTPM
Small intestine	56.3 nTPM
Rectum	25.4 nTPM
Colon	13.2 nTPM

Plasma cells	36.1 nTPM
Adipose tissue	81.9 nTPM
Esophagus	36.9 nTPM
Stomach	24.9 nTPM
Spleen	18.9 nTPM
Bone marrow	18.2 nTPM

Respiratory ciliated cells	18.3 nTPM
Lung	26.2 nTPM
Bronchus	10.3 nTPM

Smooth muscle cells	30.8 nTPM
Adipose tissue	69.3 nTPM
Heart muscle	53.0 nTPM
Skeletal muscle	47.9 nTPM
Breast	39.8 nTPM
Endometrium	32.9 nTPM
Skin	25.8 nTPM
Ovary	17.8 nTPM
Esophagus	17.0 nTPM
Pancreas	13.4 nTPM
Prostate	12.5 nTPM
Bronchus	9.5 nTPM

T-cells	55.3 nTPM
Adipose tissue	105.6 nTPM
PBMC	87.3 nTPM
Kidney	80.1 nTPM
Liver	72.6 nTPM
Endometrium	69.8 nTPM
Lung	65.3 nTPM
Breast	55.7 nTPM
Colon	54.6 nTPM
Skeletal muscle	48.0 nTPM
Prostate	47.3 nTPM
Ovary	46.7 nTPM
Bone marrow	39.2 nTPM
Spleen	38.7 nTPM
Lymph node	36.0 nTPM
Esophagus	32.8 nTPM
Skin	32.3 nTPM
Stomach	28.5 nTPM

Basal prostatic cells	16.1 nTPM
Prostate	16.1 nTPM

Cholangiocytes	57.2 nTPM
Liver	57.2 nTPM

Collecting duct cells	82.8 nTPM
Kidney	82.8 nTPM

Cone photoreceptor cells	95.9 nTPM
Eye	95.9 nTPM

Undifferentiated cells	21.3 nTPM
Colon	25.2 nTPM
Small intestine	21.4 nTPM
Rectum	17.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC