Single cell type - NKTR - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NKTR
Gene descriptionⁱ Full gene name according to HGNC.	Natural killer cell triggering receptor
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

NKTR is part of cluster 52 Non-specific - Transcription with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ARGLU1	Arginine and glutamate rich 1	0.6521	52
CCNL2	Cyclin L2	0.6500	52
PRPF4B	Pre-mRNA processing factor 4B	0.6346	52
SPG7	SPG7 matrix AAA peptidase subunit, paraplegin	0.6265	52
ZNF26	Zinc finger protein 26	0.6195	52
CWF19L2	CWF19 like cell cycle control factor 2	0.6051	52
BOD1L1	Biorientation of chromosomes in cell division 1 like 1	0.6003	52
LUC7L	LUC7 like	0.5887	52
GON4L	Gon-4 like	0.5876	46
ZNF160	Zinc finger protein 160	0.5841	52
SHPRH	SNF2 histone linker PHD RING helicase	0.5835	52
ZNF621	Zinc finger protein 621	0.5781	52
GOLGA8A	Golgin A8 family member A	0.5716	52
KMT2B	Lysine methyltransferase 2B	0.5648	52
DDX17	DEAD-box helicase 17	0.5554	52

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	221.8 nTPM
Adipose tissue	305.4 nTPM
Breast	138.2 nTPM

Alveolar cells type 1	109.0 nTPM
Lung	109.0 nTPM

Alveolar cells type 2	141.4 nTPM
Lung	141.4 nTPM

Astrocytes	169.4 nTPM
Brain	169.4 nTPM

B-cells	129.5 nTPM
Adipose tissue	231.0 nTPM
PBMC	161.3 nTPM
Colon	150.2 nTPM
Breast	137.8 nTPM
Stomach	134.4 nTPM
Bone marrow	115.3 nTPM
Lymph node	101.0 nTPM
Kidney	95.3 nTPM
Spleen	91.7 nTPM
Liver	77.4 nTPM

Dendritic cells	156.0 nTPM
Adipose tissue	239.1 nTPM
Breast	157.1 nTPM
PBMC	71.8 nTPM

Endothelial cells	166.2 nTPM
Heart muscle	431.5 nTPM
Skeletal muscle	342.3 nTPM
Testis	290.9 nTPM
Lung	190.3 nTPM
Prostate	149.6 nTPM
Endometrium	149.3 nTPM
Ovary	130.3 nTPM
Eye	130.2 nTPM
Liver	112.8 nTPM
Breast	111.6 nTPM
Placenta	96.7 nTPM
Skin	85.9 nTPM
Esophagus	62.8 nTPM
Pancreas	42.5 nTPM

Fibroblasts	83.3 nTPM
Skeletal muscle	111.3 nTPM
Lung	99.4 nTPM
Breast	98.6 nTPM
Adipose tissue	96.7 nTPM
Ovary	93.8 nTPM
Prostate	93.1 nTPM
Heart muscle	92.3 nTPM
Placenta	67.6 nTPM
Skin	66.4 nTPM
Esophagus	50.6 nTPM
Stomach	46.0 nTPM

Intestinal goblet cells	70.2 nTPM
Colon	97.2 nTPM
Small intestine	58.2 nTPM
Rectum	55.2 nTPM

Macrophages	78.9 nTPM
Adipose tissue	138.1 nTPM
Lung	124.6 nTPM
Breast	112.7 nTPM
Skeletal muscle	97.1 nTPM
Testis	93.0 nTPM
Endometrium	83.7 nTPM
Stomach	82.1 nTPM
Ovary	79.7 nTPM
Bone marrow	74.9 nTPM
Kidney	70.4 nTPM
Esophagus	59.8 nTPM
Spleen	58.1 nTPM
Prostate	56.1 nTPM
PBMC	27.3 nTPM
Pancreas	25.5 nTPM

Paneth cells	59.2 nTPM
Small intestine	78.9 nTPM
Colon	49.4 nTPM
Rectum	49.2 nTPM

Plasma cells	131.3 nTPM
Adipose tissue	405.1 nTPM
Stomach	86.0 nTPM
Spleen	63.2 nTPM
Bone marrow	59.4 nTPM
Esophagus	43.0 nTPM

Respiratory ciliated cells	53.3 nTPM
Bronchus	57.1 nTPM
Lung	49.5 nTPM

Smooth muscle cells	88.9 nTPM
Heart muscle	143.5 nTPM
Adipose tissue	132.7 nTPM
Skeletal muscle	111.9 nTPM
Endometrium	111.8 nTPM
Ovary	108.4 nTPM
Breast	95.6 nTPM
Skin	66.2 nTPM
Prostate	65.7 nTPM
Bronchus	65.3 nTPM
Pancreas	46.1 nTPM
Esophagus	31.0 nTPM

T-cells	164.4 nTPM
Adipose tissue	337.1 nTPM
Skeletal muscle	290.6 nTPM
Lung	250.6 nTPM
Endometrium	219.7 nTPM
PBMC	206.6 nTPM
Breast	184.6 nTPM
Colon	164.9 nTPM
Skin	158.5 nTPM
Ovary	149.0 nTPM
Kidney	147.2 nTPM
Liver	132.3 nTPM
Bone marrow	116.6 nTPM
Prostate	108.9 nTPM
Lymph node	103.7 nTPM
Stomach	95.9 nTPM
Spleen	95.2 nTPM
Esophagus	32.8 nTPM

Basal keratinocytes	59.0 nTPM
Skin	59.0 nTPM

Basal prostatic cells	60.3 nTPM
Prostate	60.3 nTPM

Basal respiratory cells	57.8 nTPM
Bronchus	57.8 nTPM

Basal squamous epithelial cells	66.0 nTPM
Esophagus	66.0 nTPM

Undifferentiated cells	75.0 nTPM
Colon	100.0 nTPM
Small intestine	64.6 nTPM
Rectum	60.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC