Cell line - PID1 - The Human Protein Atlas

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PID1

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PID1
Gene descriptionⁱ Full gene name according to HGNC.	Phosphotyrosine interaction domain containing 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	RH-30 & LHCN-M2 - Muscle contraction (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (ASC diff, hTEC/SVTERT24-B, LHCN-M2, REH, RH-30)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

PID1 is part of cluster 31 RH-30 & LHCN-M2 - Muscle contraction with confidenceⁱ 1
274 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TSHZ3	Teashirt zinc finger homeobox 3	0.7727	31
KCNJ2	Potassium inwardly rectifying channel subfamily J member 2	0.7247	31
KLHL41	Kelch like family member 41	0.7047	31
NEXN	Nexilin F-actin binding protein	0.7002	31
ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif 5	0.6957	34
CHRNA1	Cholinergic receptor nicotinic alpha 1 subunit	0.6933	31
MUSK	Muscle associated receptor tyrosine kinase	0.6921	31
MAMSTR	MEF2 activating motif and SAP domain containing transcriptional regulator	0.6897	31
MYOG	Myogenin	0.6877	31
CHRNG	Cholinergic receptor nicotinic gamma subunit	0.6842	31
C1QTNF2	C1q and TNF related 2	0.6794	31
DES	Desmin	0.6794	31
TNNI1	Troponin I1, slow skeletal type	0.6775	31
MSTN	Myostatin	0.6767	31
ENOX1	Ecto-NOX disulfide-thiol exchanger 1	0.6757	31

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.