Single cell type - BATF - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	BATF
Gene descriptionⁱ Full gene name according to HGNC.	Basic leucine zipper ATF-like transcription factor
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription regulation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (granulocytes, T-cells, Breast glandular cells, NK-cells, Urothelial cells, Breast myoepithelial cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HDLM-2, MCF7, RT4, SK-BR-3, U-937)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (granulocytes, T-cells, Breast glandular cells, NK-cells, Urothelial cells, Breast myoepithelial cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

BATF is part of cluster 24 Non-specific - Transcription regulation with confidenceⁱ 1
415 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TNFRSF9	TNF receptor superfamily member 9	0.8582	24
CCR4	C-C motif chemokine receptor 4	0.7983	24
FOXP3	Forkhead box P3	0.7940	24
PDCD1	Programmed cell death 1	0.7906	24
IL7R	Interleukin 7 receptor	0.7785	24
CD40LG	CD40 ligand	0.7757	24
PBX4	PBX homeobox 4	0.7722	24
CTLA4	Cytotoxic T-lymphocyte associated protein 4	0.7692	24
LEPROTL1	Leptin receptor overlapping transcript like 1	0.7684	24
GPR171	G protein-coupled receptor 171	0.7683	24
CCR8	C-C motif chemokine receptor 8	0.7681	24
CD28	CD28 molecule	0.7570	24
ICOS	Inducible T cell costimulator	0.7380	24
CASS4	Cas scaffold protein family member 4	0.7330	24
PMCH	Pro-melanin concentrating hormone	0.7159	24

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	2.9 nTPM
Breast	4.5 nTPM
Adipose tissue	1.3 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	29.3 nTPM
Lung	29.3 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	17.1 nTPM
Liver	26.4 nTPM
Kidney	23.8 nTPM
Lymph node	20.5 nTPM
Adipose tissue	19.5 nTPM
Spleen	18.3 nTPM
PBMC	15.7 nTPM
Bone marrow	14.7 nTPM
Breast	13.4 nTPM
Stomach	10.5 nTPM
Colon	8.0 nTPM

Dendritic cells	36.9 nTPM
Breast	69.9 nTPM
Adipose tissue	36.9 nTPM
PBMC	4.0 nTPM

Endothelial cells	5.0 nTPM
Lung	18.7 nTPM
Breast	16.1 nTPM
Prostate	13.7 nTPM
Skin	9.9 nTPM
Esophagus	4.2 nTPM
Skeletal muscle	2.2 nTPM
Liver	1.8 nTPM
Placenta	1.1 nTPM
Endometrium	0.9 nTPM
Heart muscle	0.4 nTPM
Testis	0.3 nTPM
Ovary	0.2 nTPM
Eye	0.0 nTPM
Pancreas	0.0 nTPM

Fibroblasts	4.4 nTPM
Stomach	13.4 nTPM
Lung	12.3 nTPM
Heart muscle	6.9 nTPM
Breast	5.0 nTPM
Skin	4.4 nTPM
Prostate	3.8 nTPM
Placenta	1.6 nTPM
Esophagus	0.7 nTPM
Skeletal muscle	0.6 nTPM
Ovary	0.1 nTPM
Adipose tissue	0.1 nTPM

Intestinal goblet cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Macrophages	21.7 nTPM
Skeletal muscle	34.4 nTPM
Kidney	33.3 nTPM
Pancreas	33.2 nTPM
Bone marrow	31.2 nTPM
Breast	28.4 nTPM
Prostate	27.5 nTPM
Ovary	24.5 nTPM
Lung	17.9 nTPM
Spleen	17.6 nTPM
Stomach	17.6 nTPM
Esophagus	17.3 nTPM
Adipose tissue	17.2 nTPM
Endometrium	13.0 nTPM
Testis	11.7 nTPM
PBMC	0.0 nTPM

Paneth cells	0.1 nTPM
Rectum	0.2 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	29.9 nTPM
Bone marrow	54.4 nTPM
Adipose tissue	52.2 nTPM
Spleen	34.7 nTPM
Stomach	8.3 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	12.8 nTPM
Bronchus	15.4 nTPM
Lung	10.2 nTPM

Smooth muscle cells	2.0 nTPM
Bronchus	5.7 nTPM
Prostate	5.6 nTPM
Breast	4.8 nTPM
Skin	2.8 nTPM
Esophagus	1.5 nTPM
Skeletal muscle	0.7 nTPM
Heart muscle	0.6 nTPM
Endometrium	0.4 nTPM
Pancreas	0.2 nTPM
Ovary	0.1 nTPM
Adipose tissue	0.0 nTPM

T-cells	116.5 nTPM
Prostate	288.8 nTPM
Adipose tissue	259.4 nTPM
Stomach	189.4 nTPM
Skin	153.8 nTPM
Colon	147.3 nTPM
Lymph node	122.6 nTPM
Skeletal muscle	106.0 nTPM
Ovary	102.3 nTPM
Breast	93.7 nTPM
Lung	83.6 nTPM
Bone marrow	80.3 nTPM
Kidney	78.0 nTPM
Spleen	74.0 nTPM
Liver	69.3 nTPM
Esophagus	58.9 nTPM
PBMC	38.6 nTPM
Endometrium	33.8 nTPM

Basal keratinocytes	5.4 nTPM
Skin	5.4 nTPM

Basal prostatic cells	50.8 nTPM
Prostate	50.8 nTPM

Collecting duct cells	3.7 nTPM
Kidney	3.7 nTPM

Early spermatids	0.5 nTPM
Testis	0.5 nTPM

Undifferentiated cells	0.5 nTPM
Colon	1.5 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC