Single cell type - AIFM1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	AIFM1
Gene descriptionⁱ Full gene name according to HGNC.	Apoptosis inducing factor mitochondria associated 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	14

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Proximal tubular cells - Tubular reabsorption (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal tubular cells, Cardiomyocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal tubular cells, Cardiomyocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

AIFM1 is part of cluster 67 Proximal tubular cells - Tubular reabsorption with confidenceⁱ 1
499 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
GCAT	Glycine C-acetyltransferase	0.8269	67
ACADM	Acyl-CoA dehydrogenase medium chain	0.7612	67
ACAT1	Acetyl-CoA acetyltransferase 1	0.7563	67
C11orf54	Chromosome 11 open reading frame 54	0.7538	67
LYG1	Lysozyme g1	0.7512	67
MIOX	Myo-inositol oxygenase	0.7503	67
RBP5	Retinol binding protein 5	0.7484	67
SUCLG1	Succinate-CoA ligase GDP/ADP-forming subunit alpha	0.7481	67
MDH1	Malate dehydrogenase 1	0.7437	39
BBOX1	Gamma-butyrobetaine hydroxylase 1	0.7420	67
AK4	Adenylate kinase 4	0.7398	67
NIT2	Nitrilase family member 2	0.7381	67
PTER	Phosphotriesterase related	0.7364	67
MAJIN	Membrane anchored junction protein	0.7347	67
TEX51	Testis expressed 51	0.7314	67

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	12.6 nTPM
Breast	14.8 nTPM
Adipose tissue	10.2 nTPM

Alveolar cells type 1	16.0 nTPM
Lung	16.0 nTPM

Alveolar cells type 2	20.1 nTPM
Lung	20.1 nTPM

Astrocytes	17.0 nTPM
Brain	17.0 nTPM

B-cells	17.1 nTPM
Liver	45.4 nTPM
Kidney	28.5 nTPM
Breast	20.0 nTPM
PBMC	17.1 nTPM
Colon	14.4 nTPM
Spleen	12.1 nTPM
Bone marrow	11.5 nTPM
Lymph node	9.4 nTPM
Stomach	7.7 nTPM
Adipose tissue	5.0 nTPM

Dendritic cells	14.2 nTPM
PBMC	16.0 nTPM
Breast	16.0 nTPM
Adipose tissue	10.7 nTPM

Endothelial cells	11.5 nTPM
Heart muscle	24.8 nTPM
Placenta	22.7 nTPM
Ovary	14.5 nTPM
Testis	12.5 nTPM
Breast	12.2 nTPM
Pancreas	11.6 nTPM
Endometrium	11.2 nTPM
Skin	10.8 nTPM
Skeletal muscle	9.1 nTPM
Eye	8.9 nTPM
Prostate	8.0 nTPM
Esophagus	7.7 nTPM
Liver	7.3 nTPM
Lung	0.0 nTPM

Fibroblasts	16.4 nTPM
Heart muscle	53.6 nTPM
Lung	30.1 nTPM
Ovary	19.1 nTPM
Placenta	16.9 nTPM
Breast	11.5 nTPM
Adipose tissue	10.1 nTPM
Skeletal muscle	9.7 nTPM
Skin	9.1 nTPM
Stomach	8.9 nTPM
Esophagus	6.6 nTPM
Prostate	5.0 nTPM

Intestinal goblet cells	24.0 nTPM
Colon	34.3 nTPM
Rectum	19.9 nTPM
Small intestine	17.7 nTPM

Macrophages	16.8 nTPM
Pancreas	33.2 nTPM
Kidney	31.0 nTPM
Ovary	29.1 nTPM
Lung	22.7 nTPM
Endometrium	20.9 nTPM
Breast	17.1 nTPM
Testis	16.9 nTPM
Bone marrow	15.0 nTPM
Adipose tissue	14.3 nTPM
Prostate	13.8 nTPM
Skeletal muscle	13.5 nTPM
Stomach	11.7 nTPM
Spleen	9.3 nTPM
Esophagus	3.1 nTPM
PBMC	0.0 nTPM

Paneth cells	18.9 nTPM
Rectum	22.0 nTPM
Colon	19.7 nTPM
Small intestine	15.0 nTPM

Plasma cells	19.2 nTPM
Spleen	37.1 nTPM
Bone marrow	23.0 nTPM
Stomach	19.5 nTPM
Adipose tissue	10.3 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	21.3 nTPM
Lung	23.3 nTPM
Bronchus	19.4 nTPM

Smooth muscle cells	39.3 nTPM
Bronchus	281.4 nTPM
Heart muscle	38.5 nTPM
Pancreas	28.7 nTPM
Ovary	16.4 nTPM
Endometrium	14.4 nTPM
Breast	11.9 nTPM
Esophagus	10.9 nTPM
Skin	8.3 nTPM
Adipose tissue	7.9 nTPM
Prostate	7.2 nTPM
Skeletal muscle	6.6 nTPM

T-cells	15.8 nTPM
Ovary	40.0 nTPM
Kidney	30.2 nTPM
Lung	18.2 nTPM
Liver	17.4 nTPM
PBMC	16.6 nTPM
Endometrium	16.3 nTPM
Spleen	14.3 nTPM
Colon	14.2 nTPM
Breast	14.2 nTPM
Esophagus	13.1 nTPM
Stomach	13.0 nTPM
Bone marrow	12.2 nTPM
Lymph node	12.0 nTPM
Skeletal muscle	10.7 nTPM
Prostate	9.5 nTPM
Adipose tissue	9.3 nTPM
Skin	7.8 nTPM

Basal keratinocytes	8.7 nTPM
Skin	8.7 nTPM

Basal prostatic cells	8.2 nTPM
Prostate	8.2 nTPM

Basal respiratory cells	25.0 nTPM
Bronchus	25.0 nTPM

Cholangiocytes	22.8 nTPM
Liver	22.8 nTPM

Undifferentiated cells	37.2 nTPM
Colon	44.5 nTPM
Rectum	33.7 nTPM
Small intestine	33.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC