Single cell type - NDUFV1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NDUFV1
Gene descriptionⁱ Full gene name according to HGNC.	NADH:ubiquinone oxidoreductase core subunit V1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	12

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal tubular cells, Cardiomyocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal tubular cells, Cardiomyocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

NDUFV1 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 1
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NDUFS8	NADH:ubiquinone oxidoreductase core subunit S8	0.8140	39
UQCRC1	Ubiquinol-cytochrome c reductase core protein 1	0.7631	39
MRPL21	Mitochondrial ribosomal protein L21	0.6929	39
CYC1	Cytochrome c1	0.6780	39
NDUFS3	NADH:ubiquinone oxidoreductase core subunit S3	0.6546	39
AIFM1	Apoptosis inducing factor mitochondria associated 1	0.6455	67
NDUFS2	NADH:ubiquinone oxidoreductase core subunit S2	0.6414	10
PNKD	PNKD metallo-beta-lactamase domain containing	0.6312	39
NDUFA10	NADH:ubiquinone oxidoreductase subunit A10	0.6102	39
MRPL12	Mitochondrial ribosomal protein L12	0.6036	53
NDUFS6	NADH:ubiquinone oxidoreductase subunit S6	0.5960	39
ECSIT	ECSIT signaling integrator	0.5952	39
GPS1	G protein pathway suppressor 1	0.5941	39
GCAT	Glycine C-acetyltransferase	0.5840	67
IDH3B	Isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta	0.5752	39

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	54.6 nTPM
Breast	60.0 nTPM
Adipose tissue	49.2 nTPM

Alveolar cells type 1	60.9 nTPM
Lung	60.9 nTPM

Alveolar cells type 2	75.0 nTPM
Lung	75.0 nTPM

Astrocytes	33.3 nTPM
Brain	33.3 nTPM

B-cells	76.2 nTPM
Liver	148.0 nTPM
Bone marrow	105.5 nTPM
Spleen	98.0 nTPM
Stomach	69.0 nTPM
Lymph node	68.0 nTPM
Breast	64.1 nTPM
Kidney	61.9 nTPM
PBMC	61.4 nTPM
Colon	47.9 nTPM
Adipose tissue	38.1 nTPM

Dendritic cells	72.8 nTPM
PBMC	83.7 nTPM
Breast	78.0 nTPM
Adipose tissue	56.8 nTPM

Endothelial cells	56.7 nTPM
Heart muscle	92.7 nTPM
Skin	77.2 nTPM
Breast	68.3 nTPM
Ovary	65.0 nTPM
Placenta	64.8 nTPM
Pancreas	57.9 nTPM
Eye	56.7 nTPM
Esophagus	51.8 nTPM
Prostate	49.5 nTPM
Skeletal muscle	48.0 nTPM
Testis	44.5 nTPM
Liver	43.1 nTPM
Lung	37.4 nTPM
Endometrium	36.9 nTPM

Enteroendocrine cells	98.5 nTPM
Rectum	118.9 nTPM
Colon	78.1 nTPM

Fibroblasts	82.4 nTPM
Heart muscle	187.5 nTPM
Ovary	109.1 nTPM
Placenta	99.7 nTPM
Skin	80.8 nTPM
Adipose tissue	72.8 nTPM
Breast	71.4 nTPM
Stomach	69.8 nTPM
Esophagus	67.9 nTPM
Skeletal muscle	50.8 nTPM
Prostate	50.0 nTPM
Lung	47.0 nTPM

Intestinal goblet cells	155.9 nTPM
Colon	199.4 nTPM
Rectum	155.5 nTPM
Small intestine	112.8 nTPM

Macrophages	68.4 nTPM
Kidney	109.6 nTPM
Spleen	94.3 nTPM
Pancreas	89.3 nTPM
Ovary	86.0 nTPM
Bone marrow	77.4 nTPM
Stomach	73.3 nTPM
Adipose tissue	70.1 nTPM
Esophagus	69.3 nTPM
Breast	67.5 nTPM
Prostate	66.4 nTPM
Testis	63.3 nTPM
Lung	58.9 nTPM
Endometrium	51.3 nTPM
Skeletal muscle	48.5 nTPM
PBMC	0.0 nTPM

Paneth cells	122.8 nTPM
Rectum	156.0 nTPM
Colon	145.0 nTPM
Small intestine	67.5 nTPM

Plasma cells	146.6 nTPM
Spleen	199.3 nTPM
Stomach	170.8 nTPM
Esophagus	160.2 nTPM
Bone marrow	140.1 nTPM
Adipose tissue	62.5 nTPM

Respiratory ciliated cells	80.3 nTPM
Bronchus	81.8 nTPM
Lung	78.7 nTPM

Smooth muscle cells	136.9 nTPM
Bronchus	586.9 nTPM
Skin	115.4 nTPM
Pancreas	114.6 nTPM
Heart muscle	109.0 nTPM
Breast	109.0 nTPM
Ovary	95.2 nTPM
Prostate	92.6 nTPM
Skeletal muscle	81.6 nTPM
Esophagus	79.1 nTPM
Adipose tissue	69.9 nTPM
Endometrium	52.9 nTPM

Basal prostatic cells	95.9 nTPM
Prostate	95.9 nTPM

Basal respiratory cells	187.6 nTPM
Bronchus	187.6 nTPM

Cholangiocytes	61.5 nTPM
Liver	61.5 nTPM

Collecting duct cells	86.5 nTPM
Kidney	86.5 nTPM

T-cells	79.3 nTPM
Esophagus	117.9 nTPM
Stomach	114.4 nTPM
Bone marrow	113.9 nTPM
Kidney	108.9 nTPM
Spleen	107.8 nTPM
Lymph node	87.9 nTPM
Liver	85.7 nTPM
Colon	77.4 nTPM
Ovary	75.7 nTPM
Lung	74.4 nTPM
Prostate	71.1 nTPM
Breast	61.0 nTPM
Skin	60.8 nTPM
PBMC	59.8 nTPM
Adipose tissue	47.2 nTPM
Skeletal muscle	42.0 nTPM
Endometrium	41.9 nTPM

Undifferentiated cells	274.8 nTPM
Colon	381.6 nTPM
Rectum	243.1 nTPM
Small intestine	199.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC