Single cell type - CYB5R1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CYB5R1
Gene descriptionⁱ Full gene name according to HGNC.	Cytochrome b5 reductase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Extravillous trophoblasts - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Syncytiotrophoblasts, Extravillous trophoblasts, Basal keratinocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HaCaT, hTCEpi)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Syncytiotrophoblasts, Extravillous trophoblasts, Basal keratinocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CYB5R1 is part of cluster 38 Extravillous trophoblasts - Unknown function with confidenceⁱ 1
176 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TFAP2A	Transcription factor AP-2 alpha	0.6692	18
TINCR	TINCR ubiquitin domain containing	0.6535	18
DLX3	Distal-less homeobox 3	0.6239	38
FAM89A	Family with sequence similarity 89 member A	0.6206	38
RTN2	Reticulon 2	0.6158	38
GRHL1	Grainyhead like transcription factor 1	0.6043	18
SLC2A1	Solute carrier family 2 member 1	0.6033	18
XAGE2	X antigen family member 2	0.5982	38
EZHIP	EZH inhibitory protein	0.5945	38
TMPRSS13	Transmembrane serine protease 13	0.5921	38
XAGE3	X antigen family member 3	0.5900	47
AKR1B1	Aldo-keto reductase family 1 member B	0.5866	38
CLIC3	Chloride intracellular channel 3	0.5802	18
GATA3	GATA binding protein 3	0.5783	18
CTSV	Cathepsin V	0.5716	38

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	33.0 nTPM
Breast	42.2 nTPM
Adipose tissue	23.8 nTPM

Alveolar cells type 1	22.4 nTPM
Lung	22.4 nTPM

Alveolar cells type 2	29.8 nTPM
Lung	29.8 nTPM

Astrocytes	10.1 nTPM
Brain	10.1 nTPM

B-cells	15.5 nTPM
Liver	26.5 nTPM
Stomach	22.7 nTPM
Breast	21.3 nTPM
Bone marrow	15.5 nTPM
Spleen	14.9 nTPM
PBMC	14.3 nTPM
Colon	12.8 nTPM
Lymph node	11.4 nTPM
Adipose tissue	11.1 nTPM
Kidney	4.8 nTPM

Dendritic cells	15.8 nTPM
Breast	20.7 nTPM
PBMC	16.0 nTPM
Adipose tissue	10.8 nTPM

Endothelial cells	30.0 nTPM
Pancreas	42.5 nTPM
Breast	39.8 nTPM
Ovary	38.4 nTPM
Liver	37.6 nTPM
Skin	35.4 nTPM
Placenta	34.7 nTPM
Heart muscle	33.7 nTPM
Eye	31.6 nTPM
Testis	28.5 nTPM
Skeletal muscle	23.2 nTPM
Esophagus	20.6 nTPM
Prostate	20.3 nTPM
Endometrium	18.4 nTPM
Lung	15.6 nTPM

Fibroblasts	28.9 nTPM
Placenta	42.2 nTPM
Breast	40.7 nTPM
Esophagus	38.9 nTPM
Adipose tissue	34.0 nTPM
Skin	33.5 nTPM
Skeletal muscle	29.3 nTPM
Heart muscle	25.6 nTPM
Stomach	25.3 nTPM
Prostate	22.2 nTPM
Ovary	14.8 nTPM
Lung	11.1 nTPM

Intestinal goblet cells	10.8 nTPM
Rectum	13.9 nTPM
Small intestine	9.9 nTPM
Colon	8.5 nTPM

Macrophages	39.5 nTPM
PBMC	136.4 nTPM
Ovary	69.8 nTPM
Pancreas	58.7 nTPM
Testis	44.7 nTPM
Breast	39.2 nTPM
Esophagus	37.7 nTPM
Lung	32.1 nTPM
Prostate	31.0 nTPM
Bone marrow	28.7 nTPM
Kidney	23.4 nTPM
Adipose tissue	21.9 nTPM
Skeletal muscle	21.3 nTPM
Endometrium	20.5 nTPM
Spleen	14.5 nTPM
Stomach	11.7 nTPM

Paneth cells	11.3 nTPM
Rectum	12.8 nTPM
Small intestine	11.3 nTPM
Colon	9.9 nTPM

Plasma cells	12.5 nTPM
Stomach	24.9 nTPM
Adipose tissue	14.2 nTPM
Spleen	12.0 nTPM
Bone marrow	11.5 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	75.9 nTPM
Bronchus	87.6 nTPM
Lung	64.1 nTPM

Smooth muscle cells	30.0 nTPM
Breast	48.4 nTPM
Skin	41.1 nTPM
Pancreas	39.4 nTPM
Skeletal muscle	37.6 nTPM
Esophagus	35.7 nTPM
Bronchus	29.1 nTPM
Prostate	27.5 nTPM
Adipose tissue	24.2 nTPM
Heart muscle	21.7 nTPM
Ovary	14.6 nTPM
Endometrium	10.9 nTPM

T-cells	19.5 nTPM
Breast	28.1 nTPM
Skin	26.7 nTPM
Esophagus	26.2 nTPM
Ovary	24.5 nTPM
PBMC	21.4 nTPM
Kidney	21.2 nTPM
Liver	20.8 nTPM
Colon	19.0 nTPM
Spleen	18.3 nTPM
Lymph node	18.1 nTPM
Stomach	18.0 nTPM
Bone marrow	17.6 nTPM
Lung	16.7 nTPM
Adipose tissue	15.2 nTPM
Endometrium	14.4 nTPM
Prostate	14.2 nTPM
Skeletal muscle	11.4 nTPM

Cholangiocytes	37.1 nTPM
Liver	37.1 nTPM

Collecting duct cells	29.5 nTPM
Kidney	29.5 nTPM

Cone photoreceptor cells	29.2 nTPM
Eye	29.2 nTPM

Cytotrophoblasts	171.1 nTPM
Placenta	171.1 nTPM

Undifferentiated cells	14.7 nTPM
Rectum	20.3 nTPM
Small intestine	14.6 nTPM
Colon	9.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC