Single cell type - ATAD3B - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ATAD3B
Gene descriptionⁱ Full gene name according to HGNC.	ATPase family AAA domain containing 3B
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in single
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ATAD3B is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 0.99
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TOMM40	Translocase of outer mitochondrial membrane 40	0.7668	39
ATAD3A	ATPase family AAA domain containing 3A	0.7263	39
WDR4	WD repeat domain 4	0.6623	39
NCLN	Nicalin	0.5726	53
LONP1	Lon peptidase 1, mitochondrial	0.5700	39
WDR55	WD repeat domain 55	0.5656	53
ATP13A1	ATPase 13A1	0.5601	53
RABL6	RAB, member RAS oncogene family like 6	0.5593	53
SEC61A1	SEC61 translocon subunit alpha 1	0.5505	53
SLC52A2	Solute carrier family 52 member 2	0.5502	53
LRRC45	Leucine rich repeat containing 45	0.5498	53
ILF3	Interleukin enhancer binding factor 3	0.5436	39
TELO2	Telomere maintenance 2	0.5368	53
BOP1	BOP1 ribosomal biogenesis factor	0.5263	39
DOHH	Deoxyhypusine hydroxylase	0.5262	39

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	8.6 nTPM
Adipose tissue	8.9 nTPM
Breast	8.2 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	22.1 nTPM
Lung	22.1 nTPM

Astrocytes	17.6 nTPM
Brain	17.6 nTPM

B-cells	9.4 nTPM
Liver	19.3 nTPM
Spleen	14.2 nTPM
Colon	11.2 nTPM
Lymph node	10.8 nTPM
Adipose tissue	10.5 nTPM
Bone marrow	9.8 nTPM
Stomach	9.1 nTPM
Breast	6.6 nTPM
PBMC	2.8 nTPM
Kidney	0.0 nTPM

Dendritic cells	12.9 nTPM
Breast	16.4 nTPM
Adipose tissue	14.3 nTPM
PBMC	8.0 nTPM

Endothelial cells	8.2 nTPM
Ovary	13.8 nTPM
Lung	12.5 nTPM
Skeletal muscle	12.3 nTPM
Skin	10.7 nTPM
Endometrium	9.7 nTPM
Prostate	9.3 nTPM
Placenta	8.0 nTPM
Esophagus	7.8 nTPM
Eye	7.3 nTPM
Breast	7.2 nTPM
Heart muscle	6.1 nTPM
Pancreas	3.9 nTPM
Testis	3.8 nTPM
Liver	1.8 nTPM

Fibroblasts	8.7 nTPM
Ovary	19.6 nTPM
Lung	13.4 nTPM
Skin	10.5 nTPM
Placenta	10.0 nTPM
Skeletal muscle	8.1 nTPM
Heart muscle	7.0 nTPM
Prostate	7.0 nTPM
Breast	6.8 nTPM
Adipose tissue	5.5 nTPM
Stomach	4.4 nTPM
Esophagus	3.7 nTPM

Intestinal goblet cells	13.8 nTPM
Colon	25.0 nTPM
Rectum	9.7 nTPM
Small intestine	6.8 nTPM

Macrophages	7.9 nTPM
Stomach	23.5 nTPM
Bone marrow	11.3 nTPM
Esophagus	11.0 nTPM
Breast	10.5 nTPM
Lung	9.3 nTPM
Adipose tissue	9.1 nTPM
Skeletal muscle	8.5 nTPM
Ovary	8.1 nTPM
Pancreas	7.7 nTPM
Endometrium	5.4 nTPM
Kidney	5.3 nTPM
Prostate	4.6 nTPM
Spleen	3.1 nTPM
Testis	1.2 nTPM
PBMC	0.0 nTPM

Paneth cells	9.7 nTPM
Colon	16.5 nTPM
Rectum	8.8 nTPM
Small intestine	3.7 nTPM

Plasma cells	22.8 nTPM
Spleen	42.6 nTPM
Bone marrow	37.9 nTPM
Adipose tissue	21.9 nTPM
Stomach	11.6 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	8.3 nTPM
Bronchus	15.1 nTPM
Lung	1.5 nTPM

Smooth muscle cells	10.2 nTPM
Pancreas	24.5 nTPM
Ovary	15.7 nTPM
Skin	12.6 nTPM
Adipose tissue	9.7 nTPM
Skeletal muscle	9.4 nTPM
Breast	9.4 nTPM
Heart muscle	6.8 nTPM
Prostate	6.5 nTPM
Bronchus	6.4 nTPM
Endometrium	6.4 nTPM
Esophagus	4.6 nTPM

T-cells	9.9 nTPM
Breast	15.4 nTPM
Colon	15.2 nTPM
Lymph node	13.7 nTPM
Ovary	13.4 nTPM
Endometrium	12.1 nTPM
Skeletal muscle	11.9 nTPM
Liver	11.6 nTPM
Spleen	11.1 nTPM
Stomach	11.1 nTPM
Adipose tissue	10.2 nTPM
Bone marrow	10.2 nTPM
Prostate	9.5 nTPM
Skin	9.2 nTPM
PBMC	6.9 nTPM
Kidney	4.2 nTPM
Lung	3.0 nTPM
Esophagus	0.0 nTPM

Basal keratinocytes	26.3 nTPM
Skin	26.3 nTPM

Basal respiratory cells	5.2 nTPM
Bronchus	5.2 nTPM

Cone photoreceptor cells	20.9 nTPM
Eye	20.9 nTPM

Cytotrophoblasts	15.3 nTPM
Placenta	15.3 nTPM

Undifferentiated cells	20.6 nTPM
Colon	39.1 nTPM
Rectum	11.8 nTPM
Small intestine	10.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC